Extrarenale Wirkungen des Aldosterons und der Spirolactone

Determination of extracellular space and intracellular electrolytes in rat liver in vivo*

“…This could be due to more complete exsanguination in the present study or differences in analytical methods. Calculated intracellular values of 165, 22 (Dulce & Gunther, 1960;Losert et at. 1964;Senft et al 1966;Lode et at.…”

“…A number of authors have reported values for total rat-liver electrolytes which, in terms of m-mole/kg wet weight, range from 28 to 35 for Na+, [90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105] for K+, and 30-40 for C1- (Manery & Hastings, 1939;Woodbury, 1953;Leaf, 1956;Heckmann & Parsons, 1959;Dulce & Gunther, 1960;Craig, 1966). Several workers have calculated intracellular electrolytes using the 15 min volume of distribution of inulin as an extracellular indicator (Dulce & Gunther, 1960; Losert, Senft & Senft, 1964;Senft, Losert, Sitt, McEvoy & Kaess, 1966; Lode, Senft & Losert, 1967). This yields derived parameters that can be used to compare experimental and control groups of animals.…”

Stereospecific Nuclear and Cytosol Aldosterone-Binding Proteins of Various Tissues

“…Clear-cut definition of the correlation be tween physiological responsiveness to and binding activity for d-aldosterone in mammalian tissues must await the acquisition of more in formation on physiological responsiveness. For example, Losert et al [20] claimed that adrenalectomy raised intracellular sodium concen tration of the liver and that subsequent administration of aldosterone reversed this effect. It is possible, therefore, that aldosterone and related mineralocorticoids regulate not only transepithelial sodium transport but also regulate extrusion of Na+ or linked Na+:K+ move ment in a variety of tissues.…”

“…At physiological concentrations, the action of aldosterone is apparently limited to regulation of NaCl or Na+:K+ transport across secretory epithelial structures (e.g., kidney, sweat glands, intestinal mucosa and salivary glands [7,24,26,30,31,35]. A similar primary action on active Na+ transport in mésothélial, endothelial or other non-secretory cells has been proposed but not yet clearly demonstrated [19,20]. In the present study, we are concerned with the possible role of cellular aldosterone-binding proteins as determinants of the dis tinction between target and non-target tissues.…”

Mechanisms of neurogenic dystrophies induced by activation and deprivation of the sympathetic nervous system

“…It was shown that the kidney suffering from NDP had a different sensitivity to physiologically active substances including hormones (Azhipa, 1974) and mineralocorticoid aldosterone, in particular (Azhipa and Filyashina, 1980;Akimov andKositsin, 2002, 2003). It was manifested as defective reabsorption of sodium ion during NDP and inadequate renal response to aldosterone administration, which normally increases reabsorption of this ion (Crabbe, 1966(Crabbe, , 1972 due to the effect of aldosterone on sodium transport in cells of many tissues and organs, particularly, in cells of renal tubules (Losert et al ., 1964;Marver et al ., 1974). In recent decades, the involvement of corticosteroids in various body functions including nervous system activity has been actively explored (Miyashita and Hamada, 1966;De Cloet et al ., 1990;De Cloet, 1991;Maccari et al ., 1992;Deroche et al ., 1995;Akimov, 1998Akimov, , 2000.…”