Extravascular Lung Water and Sepsis

Bilgili, Beliz; Gül, Fethi; Cinel, İsmail

doi:10.5222/gkdad.2013.153

Cited by 1 publication

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathology of sepsis involves complex interactions between host organs and invading pathogens. Ultimately tissue injury and organ failure are due to negative effects of systemic activation of host immunity 2,3 . Sepsis forms a large problem in intensive care and is the main cause of death occurring there 4,5 .…”

Section: ■ Introductionmentioning

confidence: 99%

Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model

et al. 2020

View full text Add to dashboard Cite

This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1 st group was treated with cefepime, the 2 nd and 3 rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. Results: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). Conclusion: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters.

show abstract