Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model

Kapıcıbaşı, Hasan Oğuz; Kiraz, Hasan Ali; Demir, Emin Tunç; Adalı, Yasemen; Elmas, Sait

doi:10.1590/s0102-865020200060000004

Cited by 5 publications

(4 citation statements)

References 33 publications

(44 reference statements)

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“…Also, some experimental studies invoking the in vivo tests of coronavirus infected patients using OT have found this therapy beneficial in improving lung capacity, normalizing the redox potential, and also the activation of heme oxygenase (HO-1) [76]. Similar observations of the beneficial role of OT have been reported in recent case reports where O 3 has been found a potent anti-inflammatory tool [77]. Though some health supplements are also necessary addition for the COVID-19 treatment [78], the powerful antioxidant potential of O 3 has been suggested the key factor to increase O 2 in the blood and other tissues, showing profound implications in glycolysis, Krebs cycle, subcellular role in the mitochondrial antioxidative pathway and anti-inflammatory response in cytokines [79].…”

Section: Ozone Therapysupporting

confidence: 52%

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Mir¹,

Wani²,

John³

et al. 2021

Advanced Chemicobiology Research

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The year 2020 witnessed a challenging period for worldwide scientists to find a suitable treatment for the deadly novel coronavirus infectious disease-2019 (nCOVID or COVID-19). The entire scientific community has been eager to develop effective vaccines and medicine against COVID-19. Despite the fact of administration of vaccination in several countries across the globe, the drug repurposing of several antiviral compounds yielded satisfactory results in recovering the affected people. As it is a known fact that vaccination alone is not the end of this pandemic, but the final treatment in terms of drugs/medicines specific to this disease is yet underway. It looks worthy to present a literature survey based on the collective information related to the drug candidates that have been repurposed, the respective theoretical evaluation, and some of the effective therapies usable in treating COVID-19. This review also describes diagnosis and vaccination availed so far. Therefore, a sequential literature extract is hereby presented starting from the detection, going through virulence, drug repositioning, virtual screening, and the final destination in the form of vaccine development. A few commercially available vaccines have also been introduced. Based on the survey, it is clear that the entire world must remain alert for any future pandemic keeping in view the successful and unsuccessful efforts practiced in the COVID-19 pandemic.

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Section: Ozone Therapysupporting

confidence: 52%

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Mir¹,

Wani²,

John³

et al. 2021

Advanced Chemicobiology Research

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show abstract

“…In our study we also examined the levels of antiinflammatory cytokine, IL-10. IL-10 peak could be observed 24 hours after systemic damages (32,33). IL-10 production is known as a part of the protective mechanism which suppresses the induction of TNFalpha and IL-1 which are known as proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Ozone Doses Added to the Antibiotic Treatment on Cytokine Levels in Experimental Sepsis Model

TÜFEKÇİ,

GÜVEN,

BİÇERER

et al. 2023

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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We aimed to examine the changes caused by ozone therapy added to the antibiotic treatment on proinflammatory and anti-inflammatory cytokine levels in an experimental sepsis model formed with E. coli endotoxin. Rats were divided into 6 groups of 10 rats. Sepsis was formed by dosing 5 groups of rats with intraperitoneal E. coli endotoxin injection. For the first 3 groups, 0.6 mg/kg, 0.9 mg/kg, and 1.1 mg/kg doses of ozone therapy were added to the antibiotic treatment and group-4 only received antibiotic treatment. Group-5 was not treated. Group-6 received intraperitoneal serum physiologic injection simultaneously with the other groups. All treatments were sustained for 5 days. IL-1, IL-10, and TNF-alpha levels were detected in blood serum taken from rats sacrificed on day 6. It was seen that IL-1, TNF-alpha levels are significantly lower than the levels in other groups that received ozone therapy. In the comparisons amongst the groups receiving ozone therapy, it was observed that IL-1 levels do not have a significant difference and TNF-alpha levels are significantly lower in the two groups receiving lower doses than the group receiving a higher dose. There were no significant differences detected between groups at serum levels of IL-10 which is an anti-inflammatory cytokine. It was concluded that ozone added to the antibiotic treatment in sepsis could have a positive effect on survival rates by suppressing inflammatory process.

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“…Respiratory-infection-linked sepsis deaths totaled 1.8 million globally in 2017 ( Rudd et al, 2020 ) driving urgent research into the condition. Sepsis has been experimentally induced in rodents by the administration of microbial components or living pathogens (e.g., Escherichia coli , or S. aureus ) into the bloodstream, peritoneal cavity, or trachea ( Karzai et al, 2003 ; Wang et al, 2004 ; Charavaryamath et al, 2006 ; Stahl et al, 2013 ; Kapicibasi et al, 2020 ). These models have shown that sepsis induced in mice by injection of peptidoglycan causes organ injury, organ, and systemic inflammation ( Wang et al, 2004 ).…”

Section: The Pre-organoid Era: Early Attempts To Model the Human Lungmentioning

confidence: 99%

Lung Organoids—The Ultimate Tool to Dissect Pulmonary Diseases?

Bosáková

Zuani

Sládková

et al. 2022

Front. Cell Dev. Biol.

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Organoids are complex multicellular three-dimensional (3D) in vitro models that are designed to allow accurate studies of the molecular processes and pathologies of human organs. Organoids can be derived from a variety of cell types, such as human primary progenitor cells, pluripotent stem cells, or tumor-derived cells and can be co-cultured with immune or microbial cells to further mimic the tissue niche. Here, we focus on the development of 3D lung organoids and their use as disease models and drug screening tools. We introduce the various experimental approaches used to model complex human diseases and analyze their advantages and disadvantages. We also discuss validation of the organoids and their physiological relevance to the study of lung diseases. Furthermore, we summarize the current use of lung organoids as models of host-pathogen interactions and human lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or SARS-CoV-2 infection. Moreover, we discuss the use of lung organoids derived from tumor cells as lung cancer models and their application in personalized cancer medicine research. Finally, we outline the future of research in the field of human induced pluripotent stem cell-derived organoids.

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Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model

Cited by 5 publications

References 33 publications

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Effects of Different Ozone Doses Added to the Antibiotic Treatment on Cytokine Levels in Experimental Sepsis Model

Lung Organoids—The Ultimate Tool to Dissect Pulmonary Diseases?

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