Extremely preterm birth and adolescent mental health in a geographical cohort born in the 1990s

Burnett, Alice; Davey, Christopher G.; Wood, Stephen J.; Wilson-Ching, Michelle; Molloy, Carly; Cheong, Jeanie L.Y.; Doyle, Lex W.; Anderson, Peter J.

doi:10.1017/s0033291713002158

Cited by 41 publications

(41 citation statements)

References 68 publications

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“…As we have previously reported, EP/ELBW participants had a lower IQ than control participants [Cheong et al, 2013]. The groups were similar in terms of sex and history of most psychiatric disorders, although ADHD diagnoses were more prevalent in the EP/ELBW group than controls [Burnett et al, 2014].…”

Section: Demographics and Mental Illnesssupporting

confidence: 68%

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Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight

Ganella

Burnett

Cheong

et al. 2014

Human Brain Mapping

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Extremely preterm (EP, <28 weeks) and/or extremely low birth weight (ELBW, <1000 g) infants are at high risk of aberrant neurodevelopment. Sulcogyral folding patterns of the orbitofrontal cortex (OFC) are determined during the third trimester, however little is known about OFC patterning in EP/ELBW cohorts, for whom this gestational period is disturbed. This study investigated whether the distribution of OFC pattern types and frequency of intermediate and/or posterior orbital sulci (IOS/POS) differed between EP/ELBW and control adolescents. This study also investigated whether OFC pattern type was associated with mental illness or executive function outcome in adolescence. Magnetic resonance images of 194 EP/ELBW and 147 full term (>37 completed weeks) and/or normal birth weight (> 2500 g) adolescents were acquired, from which the OFC pattern of each hemisphere was classified as Type I, II, or III. Compared with controls, more EP/ELBW adolescents possessed a Type II in the left hemisphere (P = 0.019). The EP/ELBW group had fewer IOS (P = 0.024) and more POS (P = 0.021) in the left hemisphere compared with controls. OFC pattern type was not associated with mental illness, however in terms of executive functioning, Type III in the left hemisphere was associated with better parent-reported metacognition scores overall (P = 0.008) and better self-reported behavioral regulation scores in the control group (P = 0.001) compared with Type I. We show, for the first time that EP/ELBW birth is associated with changes in orbitofrontal development, and that specific patterns of OFC folding are associated with executive function at age 18 years in both EP/ELBW and control subjects.

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Section: Demographics and Mental Illnesssupporting

confidence: 68%

“…The ADHD module of the Children's Interview for Psychiatric Syndromes [Weller et al, ] was used to assess ADHD (inattentive, hyperactive/impulsive, and combined subtypes). We have previously reported these outcomes in this cohort [Burnett et al, ] and diagnoses identified were primarily ADHD, mood disorders, and anxiety disorders.…”

Section: Methodsmentioning

confidence: 99%

Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight

Ganella

Burnett

Cheong

et al. 2014

Human Brain Mapping

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“…There is also evidence of an increased risk for psychiatric disorders in adulthood, including ASD,59 ADHD62 63 and mood disorders59 64 65 demonstrating continuity with outcomes reported in childhood (figure 3). A number of studies have also reported reduced social interactions and risk-taking behaviours in VP/VLBW adolescents66 67 and higher introversion, autistic features and neuroticism which may underpin some of the social difficulties in this population.…”

Section: Outcomes In Adulthoodmentioning

confidence: 93%

Early and long-term outcome of infants born extremely preterm

2016

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There is no question that birth at extremely low gestational ages presents a significant threat to an infant's survival, health and development. Growing evidence suggests that gestational age may be conceptualised as a continuum in which births before 28 weeks of gestation (extremely preterm: EP) represent the severe end of a spectrum of health and developmental adversity. Although comprising just 1%-2% of all births, EP deliveries pose the greatest challenge to neonatal medicine and to health, education and social services for the provision of ongoing support for survivors with additional needs. Studying the outcomes of these infants remains critical for evaluating and enhancing clinical care, planning long-term support and for advancing our understanding of the life-course consequences of immaturity at birth. Here we review literature relating to early and long-term neurodevelopmental, cognitive, behavioural and educational outcomes following EP birth focusing on key themes and considering implications for intervention. SURVIVAL AND NEONATAL OUTCOMESNeonatal survival is in continuous evolution, particularly at extremely low gestational ages. Survival at the lowest gestational ages (23-24 weeks) varies in population-based reports, primarily as different countries and hospitals assume contrasting stances as to the provision of active care (figure 1). Data from the USA most vividly demonstrate this variation; 1 survival is highest in situations where more active obstetric and neonatal management is practised.2 Interpreting survival without knowing the proportion of live births for whom active stabilisation was given is impossible and reports need to be explicit with regard to this. Using population data, neonatal survival in England after birth at 22-25 weeks gestation increased by 13% from 39% (95% CI 35% to 43%) in 1995 to 52% (95% CI 49% to 55%) in 2006, 3 and routine data suggest that has continued since. Survival is highly dependent on the place of birth, being better in larger neonatal services which more frequently undertake active care. 4 In contrast, the prevalence of major neonatal morbidities-bronchopulmonary dysplasia, periventricular brain injury, retinopathy of prematurity and sepsis/necrotising enterocolitis-is essentially unchanged, despite continually evolving and less invasive strategies.

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“…However, on tasks that did not have normative data or standard scores for clinical impairment, we used a cut‐off equivalent to the 10th percentile of the full‐term control group. Detailed information about the control group characteristics and group differences for cognitive and psychiatric outcomes have been published elsewhere (Burnett et al ., ; Cheong et al ., ; Molloy, Wilson‐Ching, Doyle, Anderson, & Anderson, ; Molloy et al ., ; Wilson‐Ching et al ., ).…”

Section: Methodsmentioning

confidence: 99%

The long‐term outcome of extremely preterm (<28 weeks’ gestational age) infants with and without severe retinopathy of prematurity

Molloy

Anderson

et al. 2015

Journal of Neuropsychology

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Extremely preterm birth and adolescent mental health in a geographical cohort born in the 1990s

Cited by 41 publications

References 68 publications

Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight

Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight

Early and long-term outcome of infants born extremely preterm

The long‐term outcome of extremely preterm (<28 weeks’ gestational age) infants with and without severe retinopathy of prematurity

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