Extrusion-based additive manufacturing of PEEK for biomedical applications

Vaezi, Mohammad; Yang, Shoufeng

doi:10.1080/17452759.2015.1097053

Cited by 339 publications

(214 citation statements)

References 39 publications

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“…In 3D printing, 3D extrusion is formally known Fused Deposition Modelling (FDM), which is simple, versatile and cheap compared to laser sintering process. Other medical material such as PEEK can also be printed by FDM (12). Therefore, this study provides complementary information to prior studies at least with regard to the variety of 3D printing techniques.…”

supporting

confidence: 64%

An engineering perspective on 3D printed personalized scaffolds for tracheal suspension technique

An¹,

Chua²

2016

J. Thorac. Dis.

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3D printing is a large family of many distinct technologies covering a wide range of topics.From an engineering point of view, there should be considerations for selection of design, material, and process when using 3D printing for surgical technique innovation such as personalized scaffolds. Moreover, cost should also be considered if there are equally effective alternatives to the innovation. Furthermore, engineering considerations and options should be clearly communicated and readily available to surgeons for advancement in future.

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supporting

confidence: 64%

An engineering perspective on 3D printed personalized scaffolds for tracheal suspension technique

An¹,

Chua²

2016

J. Thorac. Dis.

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“…Process and Material PEEK is a semi-crystalline thermoplastic with high chemical resistance. Production costs are high compared with other thermoplastics, and in addition PEEK has a relatively high wear rate and high melting temperature of~343 • C, making it difficult to process [155,156]. 3D PEEK structures can be manufactured using SLS, FDM, and extrusion bioprinting.…”

Section: Polyether-ether-ketone (Peek)mentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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“…Similarly, a porous surface was found to enhance appositional tissue growth onto prostheses implanted in long bone segments in a rabbit model, resulting in direct limb mobilization and rapid return to full weight bearing . The advantages of directly manufacturing freeform biostable implants endowed with a porous structure by means of AM techniques, such as selective laser sintering and fused deposition modeling (FDM), were recently demonstrated by processing PMMA or other polymers with a well‐ascertained biocompatibility, for example, poly(ether ether ketone) . For instance, Espalin et al.…”

Section: Introductionmentioning

confidence: 99%

“…[23] The advantages of directly manufacturing freeform biostable implants endowed with a porous structure by means of AM techniques, such as selective laser sintering and fused deposition modeling (FDM), were recently demonstrated by processing PMMA [24] or other polymers with a well-ascertained biocompatibility, for example, poly(ether ether ketone). [25] For instance, Espalin et al [24a] showed the versatility of FDM in controlling the shape and porosity of PMMA implants and how their mechanical properties can be tuned by varying the implant's pores size.…”

Section: Introductionmentioning

confidence: 99%

Additive Manufacturing of Poly(Methyl Methacrylate) Biomedical Implants with Dual‐Scale Porosity

Puppi

Morelli

Bello

et al. 2018

Macro Materials & Eng

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The development of bone permanent implants with a porous structure favoring their integration with the surrounding tissues is emerging as an attractive field of application of additive manufacturing (AM). This article reports on the investigation of the suitability of a hybrid AM technique, that is, computer‐aided wet‐spinning (CAWS), to fabricate novel poly(methyl methacrylate) (PMMA) constructs as porous implant prototypes. The optimization of the processing parameters to fabricate PMMA samples with a predefined internal porous structure and different external shapes is described. The study demonstrates that tailoring post‐processing conditions represents a powerful tool to optimize samples macroscopic aspect, micromorphology, and mechanical properties. In particular, the possibility of obtaining a dual‐scale porosity through the integration of the macroporous structure determined by the material lay‐down pattern with a submicrometric porosity resulting from the phase inversion process governing polymer solidification, together with the possibility of purifying the employed commercial material from residual monomer during coagulation in ethanol, are reported as noteworthy advantages of CAWS over other AM techniques. A natural progression of this work is the development of relevant complex anatomical prototypes with tailored porosity by processing digital data obtained from computer tomography imaging of bone defects.

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Extrusion-based additive manufacturing of PEEK for biomedical applications

Cited by 339 publications

References 39 publications

An engineering perspective on 3D printed personalized scaffolds for tracheal suspension technique

An engineering perspective on 3D printed personalized scaffolds for tracheal suspension technique

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Additive Manufacturing of Poly(Methyl Methacrylate) Biomedical Implants with Dual‐Scale Porosity

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