“…Nevertheless, there are reports [5][6][7] on the need for a long course of antifungal therapy and prolonged hospital stay before clinical and radiological improvement occurs. In many instances the physiopathology of coccidioidal pleural effusions resembles that of tuberculosis as fluid collections may result from the direct extension of infection from the lung parenchyma into the pleural space or by means of immune complex pleuritis due to antigens exposure [8] .…”