Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS

Heiden, David; Saranchuk, Peter; Keenan, Jeremy D.; Ford, Nathan; Lowinger, Alan; Yen, Michael T.; McCune, Joseph M.; Rao, Narsing A.

doi:10.1016/s1473-3099(15)00269-8

Cited by 29 publications

(13 citation statements)

References 67 publications

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“…The analysis of the medical records of TB-infected male convicts showed that they were diagnosed with various forms of tuberculosis: 58 per cent infiltration, 22 per cent disseminated tuberculosis, 16 per cent fibrous cavernous tuberculosis and 4 per cent focal tuberculosis [25]. The majority of tuberculosis patients are burdened with HIVrelated (26 %) [26,27] or psychosomatic disease (diabetes, neurosis, hypertension, heart disease) -52 % [23]. In order to exclude psychopathological disorders in TBinfected male convicts, the "Method of character accentuation research" (H. Smyshek, K. Leongard) has been used.…”

Section: Resultsmentioning

confidence: 99%

Meaning of Life Orientations of TB-Infected Male Convicts: Analysis of the Pilot Research

Ganishina¹,

Комарова²,

Ilyinykh³

et al. 2020

Proceedings of the “New Silk Road: Business Cooperation and Prospective of Economic Development” (NSRBCPED 2019)

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Today in Russia proportion of TB-infected male convicts serving sentences in prisons has significantly increased. According to the data of domestic and foreign scientists (R. May, V. Frankl, A. Adler, D.A. Leontiev, A.I. Ushatikov, V.G. Deev, D.V. Sochivko, etc.), the formation of meaning of life orientations has a positive impact on the psychological state of an individual and positively correlates with the effectiveness of the treatment. In 2018, in order to study the personal characteristics of TBinfected male convicts and to determine the level of formation of their meaning of life orientations, the pilot study in the medical and correctional institution of the Russian Federation was conducted. Special attention was paid to identifying the personal (criminal, socio-demographic, medical, individual psychological) characteristics of TB-infected male convicts. The research was carried out with the help of a set of psychodiagnostic methods and techniques: observation, conversation, praximetric method (analysis of personal files and medical records), testing, the test "Methods of studying character accentuations" (H. Smishek, K. Leongard), the test "Meaning of life orientations". (D.A. Leontiem), Lusher's test, methods of mathematical statistics (correlation analysis). It was found that TB-infected male convicts are characterized by negative mental states, character accentuation, low level of formation of meaning of life orientations.

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Section: Resultsmentioning

confidence: 99%

Meaning of Life Orientations of TB-Infected Male Convicts: Analysis of the Pilot Research

Ganishina¹,

Комарова²,

Ilyinykh³

et al. 2020

Proceedings of the “New Silk Road: Business Cooperation and Prospective of Economic Development” (NSRBCPED 2019)

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“…The ULISSE study, which recently compared a standardized strategy to a free strategy for the etiological diagnosis of uveitis, shows that tuberculosis is responsible for 10.7% of the identified cause uveitis among the 676 patients included [13]. The prevalence of ocular TB is greater in immunocompromised patients [14] and asymptomatic ocular involvement is not uncommon in these subjects, justifying systematic ocular exploration [15]. This diagnosis was retained on the basis of clinical and paraclinical arguments.…”

Section: Discussionmentioning

confidence: 99%

Tubercular Uveitis in the Event of HIV Infection about a Case

Traoré¹,

Cissé²,

Tolo³

et al. 2019

JTR

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Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. This disease is the second leading cause of infectious mortality in the world after infection with the human immunodeficiency virus. We report a case of multifocal tuberculosis with neuromuscular and ocular localization in an HIV-1 immunosuppressed patient in clinical and virological failure following therapeutic discontinuation due to non-compliance. This is a 43-year-old immunocompromised HIV1 patient with a history of cerebral toxoplasmosis in 2016 who consulted for right hemiplegia. These symptoms would go back to about 3 days marked by a deficit of progressive installation of the right hemicorps preceded by diffuse headaches, of moderate intensity without triggering factor radiating to the eyes associated with an intermittent fever with periods of spontaneous remissions, night sweats and chills, non-selective anorexia, non-increasing physical asthenia and unquantified weight loss. Management was 8-month antituberculous treatment, combining the first two months isoniazid (INH), rifampicin (RMP), pyrazinamide (PZN) and ethambutol (EMB), then the next 6 months (INH) and rifampicin (RMP). The reintroduction of the same antiretroviral protocol and a reinforcement of the therapeutic education made it possible to observe a decrease of the viral load. Treatment of ocular involvement was instituted with Timosol 1 drop in the eyes morning and evening and Diclocid 1 mg/ml: 1 drop in the eyes in the morning.

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“…A recent comprehensive review identified only a few studies that assessed ocular involvement in patients with eTB, and their conclusions varied widely4: studies of disseminated TB from hospitals in India,10 Turkey15 and Malawi11 found eye lesions in 50%, 17% and 5.7%, respectively; one study of neuro-tuberculosis from an Indian hospital found ocular lesions in 35% of patients,18 and one study of patients with eTB from a hospital in Spain found eye lesions in 17% of the population 9. Several other studies have investigated eye lesions in patients with TB but have not reported eye involvement stratified by whether disease was pulmonary or extrapulmonary 8 12 13.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that asymptomatic ocular TB lesions may accompany lesions elsewhere in the body,4 eye examinations are typically not performed in the absence of visual symptoms. Given the paucity of available tests for TB and difficulty in diagnosing eTB, eye examinations could be a valuable test for patients in whom TB is suspected but tests have been negative.…”

Section: Introductionmentioning

confidence: 99%

Fundus findings in a series of patients with extrapulmonary tuberculosis in Thailand

et al. 2017

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Ocular lesions consistent with TB were not rare in a group of patients who were undergoing or had recently completed treatment for eTB. Fundus examination may provide diagnostic information that could influence a clinician's beliefs when diagnosing eTB. Given the low costs and immediate results of eye examination, this diagnostic test should be considered in patients suspected for eTB, especially when other tests are negative.

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Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS

Cited by 29 publications

References 67 publications

Meaning of Life Orientations of TB-Infected Male Convicts: Analysis of the Pilot Research

Meaning of Life Orientations of TB-Infected Male Convicts: Analysis of the Pilot Research

Tubercular Uveitis in the Event of HIV Infection about a Case

Fundus findings in a series of patients with extrapulmonary tuberculosis in Thailand

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