Eye Involvement in the Spondyloarthropathies

Bañares, A; Hernández-Garcı́a, César; Fernández‐Gutiérrez, Benjamín; Jover, Juan A.

doi:10.1016/s0889-857x(05)70041-7

Cited by 75 publications

(44 citation statements)

References 29 publications

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“…1,2 These patients with uveitis usually respond well to local topical treatment, and systemic drugs are usually not necessary. 3,4 However, it has been reported that 34% of patients with uveitis have AAU that recurs in either a variable period of time or after completion of topical corticosteroid taper.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 However, it has been reported that 34% of patients with uveitis have AAU that recurs in either a variable period of time or after completion of topical corticosteroid taper. 1,2 In these cases, a benign disease, such as AAU can produce long-term pharmacological mydriasis, deleterious effects of chronic treatment with topical steroids, and complications due to the recurrent flare-ups of uveitis itself. There is no agreement on how to manage these patients, but treatment with disease-modifying antirheumatic drugs could be an option.…”

Section: Introductionmentioning

confidence: 99%

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Methotrexate: an option for preventing the recurrence of acute anterior uveitis

Muñóz-Fernández

García‐Aparicio

Hidalgo

et al. 2008

Eye

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Aims To evaluate the efficacy of methotrexate (MTX) in preventing the recurrence of acute anterior uveitis (AAU). Methods This prospective, open, longitudinal study included patients from June 2002 to March 2005 who had either three or more episodes of AAU in the previous year, or a recurrence of AAU within 3 months before starting the trial. We excluded uveitis of infectious origin, masquerade syndromes, and patients with contraindications to MTX. The response criteria were defined as an absence of symptoms and the presence of a normal ophthalmologic examination. The study outcome compared the number of flare-ups of uveitis over an MTX-treated for 1 year to the number of flare-ups of the same group during the previous year without MTX. Results A total of 571 patients with uveitis were evaluated during the period of the study, and 10 fulfilled the inclusion criteria. One patient refused the treatment, and nine completed the study. The mean number of recurrences in the pre-MTX year was 3.4 (SD: 0.52), which was significantly reduced to 0.89 (SD: 1.17) in the year of treatment (P ¼ 0.011). Conclusion MTX treatment seems to reduce the number of flare-ups in patients with recurrent AAU.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methotrexate: an option for preventing the recurrence of acute anterior uveitis

Muñóz-Fernández

García‐Aparicio

Hidalgo

et al. 2008

Eye

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“…23 The association between HLA-B27 and AAU was fi rst reported by Brewerton et al em 1973, 24 being currently well established as a distinct nosological entity, with peculiar characteristics, such as earlier onset, unilateral involvement, and greater frequency of relapse, diversity, severity, complications, and possibility of low visual acuity 19 as compared with those of HLA-B27-negative patients. Approximately 30%-50% of the cases of AAU are associated with the presence of the HLA-B27antigen, 25,26 and, in approximately 90% of those cases, AS can be diagnosed.…”

Section: Hla-b27 and Aau Associationmentioning

confidence: 99%

Espondilite anquilosante e uveíte: revisão

Gouveia

Elmann

Morales³

2012

Rev. Bras. Reumatol.

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The present article reviews the epidemiology, pathogenesis, clinical features, diagnosis, and treatment of ankylosing spondylitis and its association with ocular changes. The authors used the PubMed (MEDLINE), LILACS, and Ophthalmology Library databases. Ankylosing spondylitis is a chronic infl ammatory disease that usually affects the axial skeleton and can progress to stiffness and progressive functional limitation. Ankylosing spondylitis usually begins around the second to third decade of life, preferentially in HLA-B27-positive white males. Its etiology and pathogenesis are not completely understood, and its diagnosis is diffi cult. Clinical control and treatment are frequently satisfactory. Acute anterior uveíte is the most common extra-articular manifestation, occurring in 20%-30% of the patients with ankylosing spondylitis. Approximately half of the acute anterior uveíte cases are associated with the presence of the HLA-B27 antigen. It can be the fi rst manifestation of an undiagnosed rheumatic disease, usually having a good prognosis and appropriate response to treatment. In conclusion, for better assessment and treatment of patients with uveitis, ophthalmologists and rheumatologists should work together.

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“…Иногда увеит оказывается первым проявлением указанных болезней и, соответственно, служит клю-чом к их диагностике. Например, частота увеита при АС составляет 20-40%, реактивном артрите -12-37%, псориатическом артрите -7-16%, воспалитель-ных заболеваниях кишечника -2-9% [3,4]. И наобо-рот, вероятность развития АС у больных увеитом со-ставляет 15%.…”

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“…И наобо-рот, вероятность развития АС у больных увеитом со-ставляет 15%. Она увеличивается до 30-50% у пациен-тов с острым передним увеитом и достигает 85-90%, если последний сочетается с наличием HLA-B27 [4]. J. Fernandez-Melon и соавт.…”

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UVEITIS INA RHEUMATOLOGISTS PRACTICE: A ROLE OF TUMOR NECROSIS FACTOR-а INHIBITORS

Моисеев¹

2009

Modern Rheumatology Journal

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Uveitis frequently develops in patients with ankylosing spondylitis (AS) and other autoimmune diseases. It is occasionally characterized by a severe recurrent course and untreatable with systemic glucocorticoids (GC) and standard immunosuppressive agents. The results of (mainly small) clinical trials, as well as some observations suggest that therapy with tumor necrosis factor-α (TNF-α) inhibitors is effective in such

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Eye Involvement in the Spondyloarthropathies

Cited by 75 publications

References 29 publications

Methotrexate: an option for preventing the recurrence of acute anterior uveitis

Methotrexate: an option for preventing the recurrence of acute anterior uveitis

Espondilite anquilosante e uveíte: revisão

UVEITIS INA RHEUMATOLOGISTS PRACTICE: A ROLE OF TUMOR NECROSIS FACTOR-а INHIBITORS

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