F-Type Lectins: Structure, Function, and Evolution

Vasta, Gerardo R.; Feng, Chiguang

doi:10.1007/978-1-0716-0430-4_23

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…In view of pest control, the negative effects on the insect immunity caused by a deficiency of fucosylation opens perspectives for novel strategies for future pest control. In such strategies, carbohydrate binding proteins, or lectins, with a specificity for fucosylated glycans, e.g., F-type lectins (Vasta et al 2017, Vasta & Feng 2020) could be used to disrupt the insect immune response against parasitoids or fungal or microbial agents. The role of lectins in the insect immune system have recently been summarized (Chen et al 2021, Ming et al 2023.…”

Section: In Insectsmentioning

confidence: 99%

Insights into protein fucosylation in insects

Yang,

De Schutter

2023

entomologia

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Fucosylation, or the attachment of a fucose moiety to a glycan or protein by the action of fucosyltransferases, happens extensively in all living organisms. It plays a vital role in multiple biological processes from development to immunity, and is thought to be highly associated with the occurrence of many human diseases. While the general principles of fucosylation are similar in all organisms, most insects synthesize less processed fucosylated glycans compared to humans. Recent studies in insects show that disruption of fucosylation causes developmental defects leading to lethality, suggesting an essential role in insects. However, because of the limited information available, the molecular mechanisms behind these phenotypes remain unresolved. This review provides an overview on insect fucosylation, including the principle and function of fucosylation, the phylogenesis of the fucosyltransferases, and the diversity and abundance of fucosylated glycans. To provide a better understanding of the different roles of fucosylation in insects, knowledge on fucosylation in mammals or other invertebrates is discussed. As the dynamic requirement for fucosylation in insects needs more research to elucidate the underlying mechanisms, we hope this overview of fucosylation could provide new insights into its role in insects for future studies.

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Section: In Insectsmentioning

confidence: 99%

Insights into protein fucosylation in insects

Yang,

De Schutter

2023

entomologia

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“…Enhanced expression of the lectins F-type lectins possess a fucose recognition domain with a "F-type" jellyroll fold and unique sequence motifs for binding calcium and carbohydrate. These lectins play a role in diverse processes including fertilization, innate immunity, adhesion of microbes, and pathogenesis [235]. F-type lectin (fucolectin) isoforms (AjFTL-1 and AjFTL-2) from the sea cucumber (Apostichopus japonicus) exhibit disparate immune roles during bacterial infection.…”

Section: Other Potential Applicationsmentioning

confidence: 99%

An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications

et al. 2022

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Lectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner. Lectins have diverse sources and are classified according to their origins, such as plant lectins, animal lectins, and fish lectins. Marine organisms including fish, crustaceans, and mollusks produce a myriad of lectins, including rhamnose binding lectins (RBL), fucose-binding lectins (FTL), mannose-binding lectin, galectins, galactose binding lectins, and C-type lectins. The widely used method of extracting lectins from marine samples is a simple two-step process employing a polar salt solution and purification by column chromatography. Lectins exert several immunomodulatory functions, including pathogen recognition, inflammatory reactions, participating in various hemocyte functions (e.g., agglutination), phagocytic reactions, among others. Lectins can also control cell proliferation, protein folding, RNA splicing, and trafficking of molecules. Due to their reported biological and pharmaceutical activities, lectins have attracted the attention of scientists and industries (i.e., food, biomedical, and pharmaceutical industries). Therefore, this review aims to update current information on lectins from marine organisms, their characterization, extraction, and biofunctionalities.

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