F-wave latency serves as the most reproducible measure in nerve conduction studies of diabetic polyneuropathy: multicentre analysis in healthy subjects and patients with diabetic polyneuropathy

Kohara, Nobuo; Kimura, Junko; Kaji, Ryuji; Goto, Yusuke; Ishii, Jun; Takiguchi, Mamoru; Nakai, Masanao

doi:10.1007/s001250051469

Cited by 133 publications

(125 citation statements)

References 13 publications

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“…The minimum F-wave latency (MFWL) was measured in the median and tibial motor nerves. The nerve conduction velocity and MFWL were measured by electromyography at 32-34°C, in accordance with the method proposed by Kohara et al [3]. The F-wave was measured 16 times, and the minimum was adopted as the value for this analysis.…”

Section: Classification Of the Severity Of Microvascular And Macrovasmentioning

confidence: 99%

Significant Association of Serum Albumin with Severity of Retinopathy and Neuropathy, in Addition to That of Nephropathy, in Japanese Type 2 Diabetic Patients

2008

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Abstract. Objective: The aim of this study was to determine the association between serum albumin and the severity of microvascular complications and presence of coronary artery disease in type 2 diabetic patients. Patients and Methods: The presence of diabetic complications was assessed in a total of 130 Japanese patients with type 2 diabetes mellitus. Retinopathy was classified as absent, simple or proliferative diabetic retinopathy. Neuropathy was considered to be present when the patient showed absence of Achilles tendon reflex, and also evaluated by measuring the median motor nerve conduction velocity (MNCV) in the nerve conduction study. Results: In relation to retinopathy, there were 83 patients with no retinopathy (absent), 26 with simple retinopathy and 21 with proliferative retinopathy. There was a significant difference in the serum albumin level between the "absent" group and the other two groups. In relation to nephropathy, there were 68 patients with no evidence of nephropathy, 49 with microalbuminuria and 13 with proteinuria. The results of logistic regression analysis with adjustment for three variables (age, gender, serum CRP) revealed that serum albumin was independently related to proliferative retinopathy and proteinuria. In relation to neuropathy, serum albumin was found to be significantly related to the absence of Achilles tendon reflex, MNCV, and MFWL. The results of multiple regression analysis with adjustment for three variables (age, gender, serum CRP) revealed that serum albumin was independently related to MNCV and MFWL. Conclusions: Serum albumin was significantly associated with the severity of retinopathy and neuropathy.

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Section: Classification Of the Severity Of Microvascular And Macrovasmentioning

confidence: 99%

Significant Association of Serum Albumin with Severity of Retinopathy and Neuropathy, in Addition to That of Nephropathy, in Japanese Type 2 Diabetic Patients

2008

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“…In the absence of (sensory) amplitudes, the nerve was scored as abnormal. Otherwise, the use of relative amplitudes was omitted because of the large variability in healthy subjects and diabetic patients (18). An overall NCS score was defined as the number of these four nerves with an abnormal conduction velocity, ranging from 0 (all normal) to 4 (all abnormal).…”

Section: Clinical Standardsmentioning

confidence: 99%

Back to Basics in Diagnosing Diabetic Polyneuropathy With the Tuning Fork!

Meijer

Smit²,

Lefrandt³

et al. 2005

Diabetes Care

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OBJECTIVE—Several national and international scoring systems are used to diagnose diabetic polyneuropathy (PNP). The variety in these scores and the lack of data on validity and predictive value has led to a comparison and validation of the scores with clinical standards for PNP to determine the most powerful measurement for screening. RESEARCH DESIGN AND METHODS—Three matched groups were selected: 24 diabetic patients with neuropathic foot ulcers, 24 diabetic patients without PNP or ulcers, and 21 control subjects without diabetes. In all participants the scores from the International Consensus on the Diabetic Foot (ICDF) and the Dutch Nederlandse Diabetes Federatie-Centraal Beleids Orgaan (NDF/CBO) were tested. The Diabetic Neuropathy Symptom score, the Diabetic Neuropathy Examination score, Heart Rate Variability, the Nerve Conduction Sum score, and a San Antonio Consensus sum score were obtained as clinical standards. Reproducibility was tested in a separate study (13 patients). RESULTS—The construct validity and discriminative power of the ICDF and NDF/CBO scores were comparable, although monofilaments (NDF/CBO) scored lower. The predictive value was good for all scores, with the best results being obtained for the tuning fork (NDF/CBO). Reproducibility of the NDF/CBO scores (monofilaments and tuning fork) was high. CONCLUSIONS—The characteristics of the scores of tests recommended by ICDF and NDF/CBO are comparable. The single use of the 128-Hz tuning fork produces results similar to the extended scores of the ICDF and much better than those of monofilaments on validation and for predictive value. For screening we therefore advise the use of the tuning fork alone.

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“…A NCS is one of the most sensitive tests because it can detect DSPN prior to the occurrence of clinical symptoms and it is widely considered as an excellent test even in the prognostic assessment of the disease through follow-up study [14][15][16] . NCSs can be divided into motor, sensory, mixed, and late response (H-reflex and F-wave) tests through which the function of the peripheral nerves can be assessed objectively and quantitatively [17][18][19][20][21] . Sensory NCSs (SNCSs) are usually used in the early detection of subclinical diabetes or in the differential diagnosis and screening of DSPN 22,23) , because the sensory nerves are generally damaged prior to motor nerve damage of the peripheral nerves [24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Sensory Nerve Conduction Studies in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Electrophysiological Features

Kang

Lee

2012

J Phys Ther Sci

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Abstract.[Purpose] To analyze the electrophysiological characteristics of diabetic sensorimotor polyneuropathy (DSPN), also known as DPN, and to determine sensitive indicators of the disease using sensory nerve conduction studies (SNCSs).[Methods] SNCSs of the median, ulnar, and sural nerve were performed on 120 patients diagnosed with DSPN and compared with those of 77 healthy controls. We performed analysis to detect abnormal conduction velocities and the distal amplitude of the compound nerve action potential (CNAP). In addition, we determined the optimal cut-off values for the diagnosis of DSPN.[Results] More severe abnormal nerve conduction was found in the lower limbs than in the upper limbs. The severity of the abnormal nerve conduction was more apparent in the distal CNAP amplitude than in the conduction velocity.[Conclusion] Our findings suggest that SNCSs of the lower limb nerve seem to be more sensitive at detecting DSPN than SNCSs of the upper limb. In particular, the sural nerve is the best indicator for the early detection of DSPN.

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F-wave latency serves as the most reproducible measure in nerve conduction studies of diabetic polyneuropathy: multicentre analysis in healthy subjects and patients with diabetic polyneuropathy

Cited by 133 publications

References 13 publications

Significant Association of Serum Albumin with Severity of Retinopathy and Neuropathy, in Addition to That of Nephropathy, in Japanese Type 2 Diabetic Patients

Significant Association of Serum Albumin with Severity of Retinopathy and Neuropathy, in Addition to That of Nephropathy, in Japanese Type 2 Diabetic Patients

Back to Basics in Diagnosing Diabetic Polyneuropathy With the Tuning Fork!

Sensory Nerve Conduction Studies in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Electrophysiological Features

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