F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome

Felice, Claudio De; Signorini, Cinzia; Durand, Thierry; Oger, Camille; Guy, Alexandre; Bultel-Poncé, Valérie; Galano, Jean Marie; Ciccoli, Lucia; Leoncini, Silvia; D’Esposito, Maurizio; Filosa, Stefania; Pecorelli, Alessandra; Valacchi, Giuseppe; Hayek, Joussef

doi:10.1194/jlr.p017798

Cited by 87 publications

(99 citation statements)

References 53 publications

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“…In the same sense, a prior study showed that plasma F 4 -NeuroPs were significantly increased in RTT (Rett syndrome) patients compared to controls [33]. Similarly, recent studies have reported that plasma levels of F 2 -Dihomo-IsoPs (ent-7(RS)-F 2t -Dihomo-IsoPs and 17-F 2t -Dihomo-IsoPs) in RTT patients in stage 1 (185.9768.9 pg/mL) were higher than in healthy controls (0.8-12 pg/mL), as measured by GC-NICI-MS [10,33,34]. Regarding other neurological diseases, in a study carried out in 1998, Roberts and colleagues detected F 4 -NeuroPs in normal human CSF of subjects with AD (Alzheimer's disease) and showed, by GC-NICI-MS, that the levels of these compounds were higher in these patients (110712 pg/mL) than in the control group (6478 pg/mL) [7].…”

Section: Discussionmentioning

confidence: 87%

Dihomo-isoprostanes—nonenzymatic metabolites of AdA—are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography–triple quadrupole–tandem mass spectrometry method

Medina

Miguel-Elízaga

Oger

et al. 2015

Free Radical Biology and Medicine

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Section: Discussionmentioning

confidence: 87%

Dihomo-isoprostanes—nonenzymatic metabolites of AdA—are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography–triple quadrupole–tandem mass spectrometry method

Medina

Miguel-Elízaga

Oger

et al. 2015

Free Radical Biology and Medicine

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“…However, the relative abundance in myelin of the precursor AdA and the increased level of F 2 -dihomo-IsoPs, strongly confirm an early and severe damage to the brain white matter as suggested by previous brain MRI evidence. Thus F 2 -dihomo-IsoPs can be considered early markers of lipid peroxidation in RTT (De Felice et al, 2011). RTT.…”

Section: Dihomo-isoprostanesmentioning

confidence: 99%

Non enzymatic metabolites of polyunsaturated fatty acids: friend or foe

Bultel-Poncé¹,

Guy²,

Oger³

et al. 2015

OCL

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-Under condition of oxidative stress, free radical mediated peroxidation of polyunsaturated fatty acids generates in vivo, cyclic metabolites like the isoprostanes, neuroprostanes, dihomo-isoprostanes, isofuranes among a large number of key products which participate in many pathophysiological processes. These metabolites display a wide range of biological actions, and some of them are now the most reliable indicators of oxidative stress in humans. In this review, we will discuss several key points of our understanding of those cyclic polyunsaturated fatty acids derivatives, going from multi-step syntheses, analytical chemistry and biological activities.Keywords: biomarkers / polyunsaturated fatty acid / radical peroxidation / isoprostanes / neuroprostanes / isofurans / total synthesis Résumé -La peroxydation radicalaire des acides gras polyinsaturés, constituants majeurs des membranes cellulaires, conduit à de nombreux métabolites, comme les isoprostanes, les neuroprostanes, les dihomo-isoprostanes, les isofuranes. Certaines isoprostanes sont à présent des marqueurs du stress oxydant cellulaire les plus significatifs utilisés en clinique. Ces lipides oxygénés possèdent également un large spectre d'activités biologiques. Cette revue fera le point sur notre dernière stratégie de synthèse organique multi-étapes pour obtenir ces molécules pures et sur des résultats récents issus de collaborations avec des collègues biologistes et cliniciens.

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“…In particular, high Biochimica et Biophysica Acta 1852 (2015) 2066-2074 levels of IsoPs and HNE, which are major lipid peroxidation products generated from membrane lipids by free radical reactions, are strongly associated with the disease natural history, genotype-phenotype correlation, clinical heterogeneity and severity of the disease [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage

Cervellati

Sticozzi

Romani

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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A strong correlation between oxidative stress (OS) and Rett syndrome (RTT), a rare neurodevelopmental disorder affecting females in the 95% of the cases, has been well documented although the source of OS and the effect of a redox imbalance in this pathology has not been yet investigated. Using freshly isolated skin fibroblasts from RTT patients and healthy subjects, we have demonstrated in RTT cells high levels of H2O2 and HNE protein adducts. These findings correlated with the constitutive activation of NADPH-oxidase (NOX) and that was prevented by a NOX inhibitor and iron chelator pre-treatment, showing its direct involvement. In parallel, we demonstrated an increase in mitochondrial oxidant production, altered mitochondrial biogenesis and impaired proteasome activity in RTT samples. Further, we found that the key cellular defensive enzymes: glutathione peroxidase, superoxide dismutase and thioredoxin reductases activities were also significantly lower in RTT. Taken all together, our findings suggest that the systemic OS levels in RTT can be a consequence of both: increased endogenous oxidants as well as altered mitochondrial biogenesis with a decreased activity of defensive enzymes that leads to posttranslational oxidant protein modification and a proteasome activity impairment.

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F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome

Cited by 87 publications

References 53 publications

Dihomo-isoprostanes—nonenzymatic metabolites of AdA—are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography–triple quadrupole–tandem mass spectrometry method

Dihomo-isoprostanes—nonenzymatic metabolites of AdA—are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography–triple quadrupole–tandem mass spectrometry method

Non enzymatic metabolites of polyunsaturated fatty acids: friend or foe

Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage

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