Fabricated Elastin

Yeo, Giselle C.; Aghaei‐Ghareh‐Bolagh, Behnaz; Brackenreg, Edwin P.; Hiob, Matti A.; Lee, Pearl; Weiss, Andrew

doi:10.1002/adhm.201801342

Cited by 4 publications

(2 citation statements)

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“…Some of the main differences between plant-and animal-based proteins are their availability and price. Plant proteins tend to be available in larger amounts and at a lower cost [31,34,39,40]. As compared to synthetic polymers, proteins are in general more challenging to electrospin due to their heterogeneity in structure and surface charge, solvent-dependent protein unfolding and low viscosity, which lead to a non-continuous electrospinning process and formation of beads [24,29].…”

Section: Proteins As a Promising Starting Materials For Electrospun Wound Dressingsmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

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With the growth of the aging population worldwide, chronic wounds represent an increasing burden to healthcare systems. Wound healing is complex and not only affected by the patient’s physiological conditions, but also by bacterial infections and inflammation, which delay wound closure and re-epithelialization. In recent years, there has been a growing interest for electrospun polymeric wound dressings with fiber diameters in the nano- and micrometer range. Such wound dressings display a number of properties, which support and accelerate wound healing. For instance, they provide physical and mechanical protection, exhibit a high surface area, allow gas exchange, are cytocompatible and biodegradable, resemble the structure of the native extracellular matrix, and deliver antibacterial agents locally into the wound. This review paper gives an overview on cytocompatible and biodegradable fibrous wound dressings obtained by electrospinning proteins and peptides of animal and plant origin in recent years. Focus is placed on the requirements for the fabrication of such drug delivery systems by electrospinning as well as their wound healing properties and therapeutic potential. Moreover, the incorporation of antimicrobial agents into the fibers or their attachment onto the fiber surface as well as their antimicrobial activity are discussed.

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Section: Proteins As a Promising Starting Materials For Electrospun Wound Dressingsmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

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“…However, the complexity is being unraveled and understood through studies of mouse models (Kielty et al, 2002). Elastin has been investigated in fields of biomedical and tissue engineering, molecular therapy, and even cosmetics (Ganceviciene et al, 2012;Lescan et al, 2018;Yeo et al, 2015). As such, elastin is involved in multiple levels of studies and analysis, ranging from topical applications to mRNA-synthesis, thus creating a demand for elastin in various forms.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Purification and Characterization of Antioxidative Bioactive Elastin Peptides from Poultry Skin

Nadalian

Kamaruzaman

Yusop

et al. 2019

Food Sci Anim Resour

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Muscle-based by-products are often undervalued although commonly reported having a high amount of natural bioactive peptides. In this study, elastin was isolated from the protein of broiler hen skin while its hydrolysate was prepared using Elastase. Assessment of antioxidative properties of elastin-based hydrolysate (EBH) was based on three different assays; 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical, 2,2'-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical and metal chelating ability. The EBH was purified further using ultrafiltration, gel filtration and Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC). The IC50 of ABTS radical activities for EBH were decreased as EBH further purified using ultrafiltration (EBH III; 0.66 mg/mL)>gel filtration (EB-II; 0.42 mg/mL)>RP-HPLC (EB-II4; 0.12 mg/mL). The sequential identification of the peptide was done by matrix-assisted laser desorption/ ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/ TOF-MS) of the potent fractions obtained from RP-HPLC (EB-II4). The presence of hydrophobic amino acids (Val and Pro) in the peptide sequences could potentially contribute to the high antioxidant activity of EBH. The sequences GAHTGPRKPFKPR, GMPGFDVR and ADASVLPK were identified as antioxidant peptides. In conclusion, the antioxidative potential from poultry skin specifically from elastin is evident and can be explored to be used in many applications such as health and pharmaceutical purposes.

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Principles of tissue stress

Horwood¹,

Chockalingam²

2023

Clinical Biomechanics in Human Locomotion

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Fabricated Elastin

Cited by 4 publications

References 0 publications

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Isolation, Purification and Characterization of Antioxidative Bioactive Elastin Peptides from Poultry Skin

Principles of tissue stress

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