In this paper, a novel method for designing and manufacturing of nosal prosthesis is presented. Using the method, multiple point sets of the patient's and volunteer's faces can be generated by 3D white light inspection system based on special binocular cameras without any damages on their skin. Based on CAD technique, volunteer's nose mesh was registered and fit in the patient's face mesh .After be merged, the undersurface of the nasal prosthesis mesh can match the remnant tissue of deformed side perfectly. By rapid prototyping manufacturing machine, the nasal prosthesis can be produced with resin and in good agreement with the deformity area. In so far, integrating non-contact white light inspection,reverse engineering with rapid prototyping manufacturing technology and without any damages on patient's skin, this approach allows us to generate custom-made nasal prostheses easily and rapidly .