Fabricating Paper Based Devices Using Correction Pens

Abstract

We present a rapid (<10 s), cost-effective, unique single-step method for fabricating paper-based devices without necessitating any expensive instrumentation, simply by deploying correction pens that are otherwise commonly used for masking typos in printed or written matters. The marked regions formed by deposits from the correction pen demonstrate ubiquitous flow resistances to typical aqueous solutions and organic solvents in the transverse direction, resulting in a preferential bulk flow along the axial direction of the paper channels ‘fabricated’ in the process. Considering the simplicity and cost-effectiveness of this platform, it is deemed to be ideal for (bio) chemical sensing and point-of-care diagnostics in resource-limited settings.

Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices

“…Nie et al described a one-step plotting method using a permanent marker and a metal mask for fabricating the device within 1 min [35]. Moreover, Chakraborty et al demonstrated a single-step method for fabricating a µPAD using correction pens within 10 s [36]. As opposed to wax patterning, this method required no heating steps as the ink penetrates during the plotting.…”

“…It involves visually observing the color change during a reaction and using it for either qualitative or quantitative analysis with the help of the naked eye or a visual aid. Colorimetric detection offers the most simple and frequently used detection in the areas of protein analysis [36,161,162,163,164], drug analysis [23,165,166,167], and ion detection [40,42,139,168,169,170,171], covering all the fields from biomedical assay to environmental monitoring as well as food safety discernment (Figure 7A).…”

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

“…Garcia et al presented a handheld stamping process that produced a µPAD in seconds independently of the user’s technical skills [ 114 ]. We considered the fabrication methods that involve digitally control (e.g., wax printing, inkjet printing, and digital cutter) provides high reproducibility compared to the manual control methods (e.g., handwriting) [ 18 , 33 , 34 , 36 , 37 , 53 , 54 , 73 , 115 ].…”

Electro‐kinetically driven route for highly sensitive blood pathology on a paper‐based device

“…Last decade has witnessed an unprecented transformation of a simple “Paper” into paper‐based analytical devices, which has revolutionized point‐of‐care diagnosis and other fields . In addition to its biodegradable, porous, and biocompatible nature, availability of facile fabrication techniques has attracted microfluidic community to leverage paper for sensing applications . Currently, amalgamation of paper‐based devices, colorimetric detection and mobile phones is considered as the holy grail for developing frugal diagnostic platforms or assays to be implemented in resource‐constrained settings .…”