Fabrication and Application of 3-D Magnetically Driven Microtools

Yamanishi, Yoko; Sakuma, Shinya; Kihara, Yuki; Arai, Fumihito

doi:10.1109/jmems.2010.2041188

Cited by 32 publications

(16 citation statements)

References 14 publications

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“…Magnetic forces are excellent driving forces for controlling micro-robots because of their non-contact nature, minimal invasiveness with respect to a cell, and low production cost. Thus, a considerable amount of research has been carried out on magnetic actuators [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Untethered micro-robot with gripping mechanism for on-chip cell surgery utilizing outer magnetic force

Ichikawa

Sakuma

Arai

et al. 2014

2014 IEEE International Conference on Robotics and Automation (ICRA)

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We have developed a highly functional untethered micro-robot that can manipulate cells with high gripping force in a micro-fluidic chip. The robot has gripping mechanism for grasping and transportation of cells with sufficient power. A permanent magnet is attached at the center of the gripping mechanism, and an electrical magnet controls the position of the magnet from the bottom of the micro-fluidic chip. The distance accuracy of the gripper is 3.0 m, and it can activate about 50 Hz. The robot has four permanent magnets for positioning, and other four permanent magnets control the robot from the bottom of the micro-fluidic chip. The robot is made very thin and small to allow maneuverability in a micro-fluidic chip. We succeeded in high-power handling and cutting of a cell using this micro-robot.

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Section: Introductionmentioning

confidence: 99%

Untethered micro-robot with gripping mechanism for on-chip cell surgery utilizing outer magnetic force

Ichikawa

Sakuma

Arai

et al. 2014

2014 IEEE International Conference on Robotics and Automation (ICRA)

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“…Several actuation methods of microrobots OPEN ACCESS have been proposed for microscale cell manipulation, such as optical tweezers [4,5], magnetic actuators [6,7] and bubble robots driven by optically induced thermocapillary flow [8]. In previous studies, we proposed magnetically driven micro-tools (MMTs) for on-chip cell manipulation [9][10][11][12]. The reason for this is that magnetic fields can be a suitable power source for an on-chip robot, because of their non-contact drive, low invasiveness with respect to a cell and low production cost.…”

Section: Introductionmentioning

confidence: 99%

“…The reason for this is that magnetic fields can be a suitable power source for an on-chip robot, because of their non-contact drive, low invasiveness with respect to a cell and low production cost. Thus, a considerable amount of research has been carried out on magnetic actuators [6,7,[9][10][11][12][13][14]. We have achieved the high speed actuation of MMTs with high output force by applying the magnetic field of horizontally arranged permanent magnets.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Nanopillar Micropatterns by Hybrid Mask Lithography for Surface-Directed Liquid Flow

2013

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This paper presents a novel method for fabricating nanopillar micropatterns for surface-directed liquid flows. It employs hybrid mask lithography, which uses a mask consisting of a combination of a photoresist and nanoparticles in the photolithography process. The nanopillar density is controlled by varying the weight ratio of nanoparticles in the composite mask. Hybrid mask lithography was used to fabricate a surface-directed liquid flow. The effect of the surface-directed liquid flow, which was formed by the air-liquid interface due to nanopillar micropatterns, was evaluated, and the results show that the oscillation of microparticles, when the micro-tool was actuated, was dramatically reduced by using a surface-directed liquid flow. Moreover, the target particle was manipulated individually without non-oscillating ambient particles.

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“…The MMT driven by a permanent magnet can be applied to wide range of cell manipulations such as loader, sorter, droplet generation, etc. [9][10][11].Enucleation by MMT was conducted previously; MMT driven by the HPD with ultrasonic vibration applied to the microchip could obtain 1.1 μm in position accuracy, and also by fabricated riblet type of MMT, which could achieve high performance in speed [12][13][14]. However it is difficult to handle the oocyte to control its posture and remove only the nucleus part since the oocyte is operated in an unconfined space.…”

Section: Introductionmentioning

confidence: 99%

Continuous enucleation of bovine oocyte by microrobot with local flow distribution control

Feng

Ichikawa

Arai

et al. 2012

2012 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3m-Nano)

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We present a continuous enucleation process of bovine oocytes on a microfluidic chip to achieve the continuous cutting of the oocytes and increasing the potential viability of the enucleated oocyte. By combining microfluidic chip and micororobotics, the flow in a channel can be actively controlled and we achieved successive operations of 1) loading oocyte, 2) control cutting volume and 3) removing nucleus. The magnetically actuated microrobot can control local fluid flow by changing its position like gate valve and control fluid force distributions in a microchip which govern oocyte movement in a chip. The optimally designed microchannel for enucleation enables continuous operation and cutting bovine oocyte with smooth manner by hydrodynamic force. The new system is propose here to show advantages by the means of the continuous operation on oocytes in a short term, cutting precision and great potentiality on continuous enucleation process for clone technology.

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Fabrication and Application of 3-D Magnetically Driven Microtools

Cited by 32 publications

References 14 publications

Untethered micro-robot with gripping mechanism for on-chip cell surgery utilizing outer magnetic force

Untethered micro-robot with gripping mechanism for on-chip cell surgery utilizing outer magnetic force

Fabrication of Nanopillar Micropatterns by Hybrid Mask Lithography for Surface-Directed Liquid Flow

Continuous enucleation of bovine oocyte by microrobot with local flow distribution control

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