2023
DOI: 10.3390/polym15071774
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Fabrication and Assessment of Orodispersible Tablets Loaded with Cubosomes for the Improved Anticancer Activity of Simvastatin against the MDA-MB-231 Breast Cancer Cell Line

Abstract: Various factors limit the use of simvastatin as an anticancer drug. Therefore, this study aimed to analyse simvastatin (SIM)-loaded cubosome efficacy against breast cancer. SIM-loaded cubosomes were prepared using the emulsification method using different glyceryl monooleate, Pluronic F127 (PF-127), and polyvinyl alcohol (PVA) ratios. The best cubosomal formula was subjected to an in vitro cytotoxicity analysis using the human breast cancer cell line, MDA-MB-231 (MDA) (ATCC, HTB-26), and formulated as oral dis… Show more

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Cited by 6 publications
(3 citation statements)
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“…Oral delivery Cyclosporin A Improved solubility, protection from harsh environments and enzymatic degradation [11,12] Simvastatin Curcumin Improved cytotoxic activities [13] Doxorubicin Improved antitumor efficacy and bioavailability, reduced risk of cardiotoxicity [14]…”
Section: Cubosomesmentioning
confidence: 99%
“…Oral delivery Cyclosporin A Improved solubility, protection from harsh environments and enzymatic degradation [11,12] Simvastatin Curcumin Improved cytotoxic activities [13] Doxorubicin Improved antitumor efficacy and bioavailability, reduced risk of cardiotoxicity [14]…”
Section: Cubosomesmentioning
confidence: 99%
“…The literature on cubosomes has grown extensively since their introduction by Larsson (apparently, the term was first used by Larsson in ref ). A case at hand is constituted by cancer treatment, where cubosomes are used to deliver anticancer drugs. , Cubic phases can accommodate a wide range of globular proteins that retain their native structure . Finally, there are outstanding scientific questions pertaining to cubic phase structures and the dynamic state of their constituents. , Information on these topics is important in the context of the above-mentioned applications of cubic phases.…”
Section: Introductionmentioning
confidence: 99%
“…A case at hand is constituted by cancer treatment, where cubosomes are used to deliver anticancer drugs. 11 , 12 Cubic phases can accommodate a wide range of globular proteins that retain their native structure. 13 Finally, there are outstanding scientific questions pertaining to cubic phase structures and the dynamic state of their constituents.…”
Section: Introductionmentioning
confidence: 99%