Fabrication and characteristics of polyHEMA artificial skin with improved tensile properties

Young, C.D.; Wu, Jing-Ran; Tsou, Tai Li

doi:10.1016/s0376-7388(98)00097-0

Cited by 58 publications

(15 citation statements)

References 14 publications

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“…In the swollen state, hydrogels are soft and rubbery, resembling natural living tissue more than any other class of synthetic biomaterials [3][4][5][6] . Therefore, hydrogels have found widespread applications in medicine as wound dressings 6,7 , contact lenses 8 and artificial skin 9 ; in tissue engineering for reparation and regeneration of organs and tissues such as bones 10,11 and cartilages 12 , and in pharmacy as controlled drug delivery systems 6,[13][14][15] . Hydrogels based on 2-hydroxyethyl methacrylate (HEMA) are very commonly studied for use as biomaterials in different applications because of theirs excellent physicochemical properties 16 .…”

Section: Introductionmentioning

confidence: 99%

“…HEMA is generally prepared in the form of copolymeric hydrogels with ionic or more hydrophilic monomers 17 . Copolymers of HEMA with methacrylic 18 , acrylic 19 and itaconic acid 20 , as pH sensitive components, have been reported previously as stimuli-responsive hydrogels for use in drug delivery systems 9 . Although many HEMA-based hydrogels are generally considered to be non-toxic and have been used in biomedical applications [21][22][23] , the information on their safety is still incomplete.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid

et al. 2016

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In this study we prepared hydrogels based on 2-hydroxyethyl methacrylate (HEMA): PHEMA homopolymer and two terpolymers of HEMA, itaconic acid (IA) and two poly(alkylene glycol) (meth) acrylates (PAGM): poly(ethylene glycol) 6 acrylate (P(HEMA/IA/PAGM1)) and poly(propylene glycol) 5 methacrylate (P(HEMA/IA/PAGM2)). Hydrogels were synthesized by gamma-irradiated radical polymerization and subjected to swelling measurements and genotoxicity evaluation. Swelling studies confirmed that these hydrogels deserve consideration as biomaterials due to their ability to swell in phosphate buffer but maintaining physical integrity for a prolonged contact time after equilibrium state has been reached. Comet assay showed certain genotoxic effect following cell exposure to extracts of hydrogels, which was dependent on the concentration of extracts, chemical composition of hydrogels and the degree of crosslinking. The influence of concentration on genotoxicity was the most pronounced. The synthesis of these novel HEMA-based hydrogels should be optimized so as to reduce their toxicity and enable the use in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid

et al. 2016

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“…Only a few findings have been reported regarding the effect of surface morphology on small proteins such as lysozyme and cytochrome 1,2 ; the majority of reports have focused on the effects of surface chemistry 3,4,5,6 . The surfaces can be categorized into four main types, namely heparinized or biological surfaces 7 , electrically charged surfaces 8 , inert surfaces 9,10 and solution-perfused surfaces 11 . Films with these surface properties have been successfully fabricated using heparin, modified collagen, carbons, polyethylene glycol (PEG) 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Anti-thrombogenicity by Layer-by-Layer

Shiratori

Matsuda

2013

MATEC Web of Conferences

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Abstract. Anti-thrombogenic films with high durability were fabricated in a wet process. Anti-thrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid)(PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming crosslinks via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. Anti-thrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 minutes, whereas with uncoated mesh blood flow stopped within 6 minutes because of blood vessel blockage by thrombus formation.

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“…However, as polysaccharides dissolve easily in water, cannot form stable hydrogel, an effective method is to make them into a synthesized polymer gel networks to form natural and synthesized polymer blend hydrogels, which is becoming a subject of academic as well as of industrial interest. Hydrogels can be applied as an interface between bone and an implant [Netti et al, 1993], as artificial skin [Young and Wu, 1998], as contact lenses [Brinkman et al, 1991], as blood contact materials [Taguchi et al, 1998] and in-controlled release applications for delivery of enzymes, hormones, contraceptives, anticoagulant, etc. [Abusafieh et al, 1997].…”

Section: Introductionmentioning

confidence: 99%