Fabrication and Characterization of 3-D Porous Collagen Scaffold

Kim, Jin‐Tae; Lim, Seungyup; Kim, Byoung Soo; Lee, Deuk Yong; Choi, Jae Ha

doi:10.9718/jber.2014.35.6.192

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…이러한 조직공학용 생분해성 재료로는 콜라겐 [2][3], 히알루론산 [4], 키토산 [5][6], 알긴산 [6] 등의 천연고분자 가 있으며 PCL(polycaprolactone) [7], PLLA(polyL-lactide) [8], PGA(polyglycolide) [9][10]…”

unclassified

Fabrication and characterization of 3-D porous scaffold by polycaprolactone

Kim¹,

Bang²,

Hyun³

et al. 2016

Journal of the Korea Academia-Industrial cooperation Society

Self Cite

View full text Add to dashboard Cite

This study was a preparatory experiment aimed the development of membrane scaffolds for tissue engineering. A PCL composite solution contained sodium chloride(NaCl). PCL porous membrane scaffolds were formed on a glass casting plate using a film applicator and immersed in distilled water to remove the NaCl reaching after drying. NaCl was used as a pore former for a 3 dimensional pore net-work. The dry condition parameters were 4℃, room temperature (RT) and 40℃ for each different temperatures in the drying experiment. SEM revealed the morphology of the pores in the membrane after drying and evaluated the in vitro cytotoxicity for basic bio-compatibility. The macro and micro pores existed together in the scaffold and showed a 3-dimensional pore net-working morphology at RT. The in vitro cytotoxicity test result was "grade 2" in accordance with the criterion for cytotoxicity by ISO 10993-5. The dry condition affected the formation of a 3 dimensional pore network and micro and macro pores. Therefore, these results are expected provide the basic process for the development of porous membrane scaffolds to control degradation and allow drug delivery.

show abstract

unclassified

Fabrication and characterization of 3-D porous scaffold by polycaprolactone

Kim¹,

Bang²,

Hyun³

et al. 2016

Journal of the Korea Academia-Industrial cooperation Society

Self Cite

View full text Add to dashboard Cite

show abstract

Effect of Spray-Type Alginate Hydrogel Dressing on Burn Wounds

Choi,

Joo,

Kang

et al. 2024

Gels

View full text Add to dashboard Cite

Immediate burn wound care is a critical factor influencing the outcomes of burn treatment. In this study, we developed a spray-type alginate hydrogel dressing that promotes wound healing, reduces pain, and increases the convenience of use in a burn treatment emergency. We investigated the efficiency of newly developed spray-type alginate hydrogel dressing on the wound healing process. We investigated the efficacy of the alginate hydrogel dressing for wound healing in 30 Sprague Dawley rats. Four deep, round second-degree burn wounds (diameter, 1.5 cm) were created bilaterally on the dorsum of the rat’s trunk; the rats were divided into four groups, in which different dressing materials were applied as follows: group A, gauze (control); group B, Mepilex™ (control); group C, 2.25% alginate hydrogel; and group D, 2.5% alginate hydrogel. The gross findings of each group were compared by tracing the remaining wound and performing visual and histological observations and biochemical analysis for proteins associated with wound healing at each time period. In burn wounds, groups C and D showed significantly higher contraction, epithelialization, and healing rates. Histologically, groups C and D showed an improved arrangement of collagen fibers and a thick epithelial layer 14 days after initial wound formation. Group C showed higher CD31, TGF-β, and fibronectin expression in Western blot analyses after day 14. This study suggests that the spray-type alginate hydrogel dressing is an effective material for initial burn wound care.

show abstract

Fabrication and Characterization of 3-D Porous Collagen Scaffold

Cited by 2 publications

References 16 publications

Fabrication and characterization of 3-D porous scaffold by polycaprolactone

Fabrication and characterization of 3-D porous scaffold by polycaprolactone

Effect of Spray-Type Alginate Hydrogel Dressing on Burn Wounds

Contact Info

Product

Resources

About