Fabrication and Characterization of a Test Platform Integrating Nanoporous Structures With Biochemical Functionality

Twomey, Karen; O'Mara, Paul; Pulka, Jaroslaw; McGillycuddy, Shane; Hurley, Eileen; Blake, Alan; Vázquez, Patricia; Vereshchagina, Elizaveta; Manning, Mary; Homsy, Alexandra; Glynn, Barry; Ogurtsov, Vladimir I.

doi:10.1109/jsen.2015.2398673

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…For this reason the AUTOSTEM project also includes the development of a novel PAT sensor. A disposable semiconductor sensor probe will be mounted into the bioreactor for in-line process control [37,38]. The electrochemical-based sensor technology allows observation of multiple biological and chemical parameters simultaneously.…”

Section: Bone Marrow Aspirationmentioning

confidence: 99%

Advances in automation for the production of clinical-grade mesenchymal stromal cells: the AUTOSTEM robotic platform

Ochs¹,

Barry²,

Schmitt³

et al. 2017

Cell Gene Therapy Insights

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Stem cell-based therapies are a central element of regenerative medicine and provide new treatment modalities for chronic and life-threatening conditions. Mesenchymal stem/stromal cells (MSCs) represent an important technology in regenerative medicine, although less developed with respect to clinical translation than hematopoietic stem cells (HSCs). MSC therapies may be based on the potential of the cells to differentiate to mesenchymal lineages or on their paracrine effects on host tissue. Both autologous and allogeneic applications are possible, the latter enabled by the low immunogenicity of the cells. Although stem cell therapy holds much promise for the treatment of chronic and debilitating diseases, there are still many obstacles to be overcome. In addition to the compelling need to generate strong and unambiguous clinical evidence, there are major technical gaps that must be filled. Chief among these is the development of manufacturing platforms for cell products that are efficient, cost effective and reproducible. Automated, robotic and closed production systems will provide the most efficient manufacturing strategy. Here we describe advances in automation for the clinical-scale production of MSCs and challenges associated with translating from lab-scale to automated large-scale manufacturing processes.

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Section: Bone Marrow Aspirationmentioning

confidence: 99%

Advances in automation for the production of clinical-grade mesenchymal stromal cells: the AUTOSTEM robotic platform

Ochs¹,

Barry²,

Schmitt³

et al. 2017

Cell Gene Therapy Insights

View full text Add to dashboard Cite

show abstract

“…These technologies lend themselves to high volume sensor chip production which will result in cheap and highly reproducible devices. An electrochemical based approach will be applied which allows for micron and nano-scale electrode dimensions to be implemented to meet the sensitivity requirements [20]. with the subject matter or materials discussed in the manuscript apart from that disclosed.…”

mentioning

confidence: 99%

Developing an Automated Robotic Factory for Novel Stem Cell Therapy Production

et al. 2016

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Recent Advances in the Modification and Characterization of Solid‐State Nanopores

Lü

Cao

Qing

2022

Chemistry An Asian Journal

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Nanopores, due to their advantages of being modifiable, controllability and sensitivity, have made a splash in recent years in the fields of biomolecular sequencing, small molecule detection, salt differential power generation, and biomimetic ion channels. In these applications, the role of chemical or biological modification is indispensable. Compared with small molecules, the modification of polymers is more difficult and the methods are more diverse. Choosing an appropriate modification method directly determines the success or failure of a research project; therefore, it is necessary to summarize polymer modification methods toward nanopores. In addition, it is also important to provide clear and convincing evidence that the nanopore modification is successful, the corresponding characterization methods are also indispensable. Therefore, this review will summarize the methods of polymer modification of nanopores and efficient characterization methods. We hope that this review will provide some reference value for like-minded researchers.

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Fabrication and Characterization of a Test Platform Integrating Nanoporous Structures With Biochemical Functionality

Cited by 5 publications

References 34 publications

Advances in automation for the production of clinical-grade mesenchymal stromal cells: the AUTOSTEM robotic platform

Advances in automation for the production of clinical-grade mesenchymal stromal cells: the AUTOSTEM robotic platform

Developing an Automated Robotic Factory for Novel Stem Cell Therapy Production

Recent Advances in the Modification and Characterization of Solid‐State Nanopores

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