Fabrication and characterization of aligned nanofibrous PLGA/Collagen blends as bone tissue scaffolds

Investigations of polycaprolactone/gelatin blends in terms of their miscibility

“…In poly(lactic-co-glycolic acid)/collagen (PLGA/Col) blends, slight shift in the ester carbonyl peaks of PLGA from 1747 to 1754 cm −1 and also slight shift in other characteristic peaks of PLGA to a higher wave number was observed with increasing Col concentration and is interpreted as sign of miscibility of those polymers [6]. According to Sionkowska [7], slight shift in the amide I peak suggests conformational changes in the collagen molecule.…”

“…Addition of some peptides like collagen (Col) or its denatured form -gelatin (Gt) to synthetic polymers like polycaprolactone (PCL) is a well-known route for improving cell adhesion in tissue engineering through introduction of amino-acid RGD sequence (Arginine-Glycine-Aspartic acid). A lot of papers describe electrospinning of nano-and submicron fibres from a mixture of synthetic polymers with biopolymers, most of them focusing on the practical aspects of scaffold effectiveness for cell cultures in vitro conditions [1][2][3][4][5][6]. Some of the papers show unexpected results related to phase content and hence some properties of such blended fibers without any attempt of physical interpretation.…”

Investigation of Human Mesenchymal Stromal Cells Cultured on PLGA or PLGA/Chitosan Electrospun Nanofibers

“…It should be taken into account that having chitosan incorporated into PLGA as a biopolymer to make it more bio-receptive also led to a decrease in the average diameter (and hence increased surface area) of the PLGA/CH nanofibers. Others have also reported a decrease in fiber diameter in polyblends of PLGA/gelatin and PLGA/collagen when compared to PLGA, as a result of adding a biopolymer to PLGA [43,44]. In our study, we performed electrospinning under optimal conditions that led to the formation of nanofibers of PLGA and PLGA/ CH with an average diameter of 680 nm and 166 nm, respectively.…”

Fabrication of Core-Shell PLGA-Chitosan Microparticles Using Electrospinning: Effects of Polymer Concentration

“…The presence of PLGA and chitosan in the core-shell PLGA-CS MPs was confirmed by analyzing the presence of specific peaks of single pure materials in the PLGA-CS spectrum such as the strong characteristic absorption bands at about 1746 cm −1 attributed to the stretching vibration of C-O bond, and the bands at 1130 cm −1 and 1412 cm −1 arose from C-O bond and methyl group C-H bond of PLGA, respectively [27]. Also in Figure 4 the absorptions bands of chitosan are shown: 1094 cm (O-H stretch) [28,29].…”