Fabrication and Characterization of Antibacterial Suture Yarns Containing PLA/Tetracycline Hydrochloride-PVA/Chitosan Nanofibers

Ranjbar‐Mohammadi, Marziyeh; Sa’di, Vida; Moezzi, Meysam; Saghafi, Reza

doi:10.1007/s12221-022-4685-z

Cited by 16 publications

(8 citation statements)

References 36 publications

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“…Compared with neat PVA nanofibers, CHN has huge −NH 2 and −OH groups in its backbone and contributes to capturing many of the added drugs (STP). 49 Next, PVA/CHN/ β-CD loaded with STP (Figure 4 c) has an ultimate surface structure. The appearance of beads beside the nanofiber’s formation can be assigned to the hydrophobic cavities of β-CD that facilitate STP incorporation into these cavities.…”

Section: Results and Discussionmentioning

confidence: 99%

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Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

Mohsen,

Abdel Gaber,

Shoueir

et al. 2024

ACS Omega

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The diagnosis and prognosis of chronic wounds are demanding and require objective assessment. Because of their potential medicinal applications, the syntheses of biopolymeric chitosan (CHN) structure and PVA-based mixed electrospun nanofibers with biomimetic features were thoroughly investigated. This study created different formulas, including a guest molecule and capping agent, using supporting PVA as a vehicle. CHN was used as a biomodifier, and beta-cyclodextrin (ß-CD) as a smoother and more efficiently entraps streptomycin (STP) compared with the silver sheet wound dressing. The relevant analyses showed that the size distribution increased with the incorporation of PVA, CHN, and ß-CD to 120.3, 161.9, and 192.02 nm. The webs boosted particle size and released content stability to 96.4% without compromising the nanofiber structure. Examining the synergistic effects of the PVA/CHN/STP/ß-CD nanoformulation against pathogenic strains of S. aureus, P. aeruginosa, and Aspergillus niger, clean zones were 47 ± 3.4, 45 ± 3.0, and 49 ± 3.7 mm were produced. PVA/CHN/STP/ß-CD formula exhibited a 98.9 ± 0.6% cell viability and wound closure of 100% at 72 h. The results reveal that the PVA/CHN/STP/ß-CD formula is promising for medical applications, especially in wound healing, compared with the silver sheet.

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Section: Results and Discussionmentioning

confidence: 99%

“…This small particle can be entered easily into the porous structures of the nanofibers. Compared with neat PVA nanofibers, CHN has huge −NH 2 and −OH groups in its backbone and contributes to capturing many of the added drugs (STP) . Next, PVA/CHN/ β-CD loaded with STP (Figure c) has an ultimate surface structure.…”

Section: Results and Discussionmentioning

confidence: 99%

Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

Mohsen,

Abdel Gaber,

Shoueir

et al. 2024

ACS Omega

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“…PLA is widely used in resorbable medical sutures due to its non-toxic nature [ 73 ]. In tissue engineering, various materials are mixed with PLA polymer to achieve higher mechanical properties.…”

Section: Fibrous Scaffolds For Anticancer Treatmentsmentioning

confidence: 99%

A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies

Zaszczyńska

Niemczyk-Soczynska

2022

Polymers

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Anticancer therapies and regenerative medicine are being developed to destroy tumor cells, as well as remodel, replace, and support injured organs and tissues. Nowadays, a suitable three-dimensional structure of the scaffold and the type of cells used are crucial for creating bio-inspired organs and tissues. The materials used in medicine are made of non-degradable and degradable biomaterials and can serve as drug carriers. Developing flexible and properly targeted drug carrier systems is crucial for tissue engineering, regenerative medicine, and novel cancer treatment strategies. This review is focused on presenting innovative biomaterials, i.e., electrospun nanofibers, 3D-printed scaffolds, and hydrogels as a novel approach for anticancer treatments which are still under development and awaiting thorough optimization.

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“…Unlike some commercially available degradable polymer sutures which can cause mild inflammatory response due to the surface lubricant, these yarns do not require the use of such lubricants. Recently, antibacterial suture yarns loaded with tetracycline hydrochloride were produced by dual-electrospinning method where chitosan/polyvinyl alcohol and PLA solutions were concomitantly injected from separate syringe [ 133 ]. Mechanical properties of woven NFs make them amenable to weaving into implantable drug-loaded nanotextiles.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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The fast advancement in nanotechnology has prompted the improvement of numerous methods for the creation of various nanoscale composites of which nanofibers have gotten extensive consideration. Nanofibers are polymeric/composite fibers which have a nanoscale diameter. They vary in porous structure and have an extensive area. Material choice is of crucial importance for the assembly of nanofibers and their function as efficient drug and biomedicine carriers. A broad scope of active pharmaceutical ingredients can be incorporated within the nanofibers or bound to their surface. The ability to deliver small molecular drugs such as antibiotics or anticancer medications, proteins, peptides, cells, DNA and RNAs has led to the biomedical application in disease therapy and tissue engineering. Although nanofibers have shown incredible potential for drug and biomedicine applications, there are still difficulties which should be resolved before they can be utilized in clinical practice. This review intends to give an outline of the recent advances in nanofibers, contemplating the preparation methods, the therapeutic loading and release and the various therapeutic applications.

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Fabrication and Characterization of Antibacterial Suture Yarns Containing PLA/Tetracycline Hydrochloride-PVA/Chitosan Nanofibers

Cited by 16 publications

References 36 publications

Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies

Nanofiber Carriers of Therapeutic Load: Current Trends

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