Fabrication and characterization of chitosan film impregnated ciprofloxacin drug: A comparative study

Rathore, Hanumant Singh; Senthilvelan, T.; Raguraman, Vasantharaja; Abraham, L. Stanley; Prakash, D.; Sivagnanam, Uma Tirichurapalli; Gupta, Sanjeev K.

doi:10.1016/j.bcab.2019.101078

Cited by 15 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The biopolymer chitosan is promising for a wide range of applications. Chitosan is derived from chitin, the second most abundant polysaccharide in nature, and has been a popular alternative to petroleum-based polyolefins due to its biodegradable and nontoxic properties. − Its biocompatible nature and antibacterial properties make chitosan an exciting material for a variety of utilizations from food packaging and sensing to pharmaceutical − and orthopedic applications. − However, due to the superior thermal, optical, and mechanical properties of petroleum-based polymers, chitosan has not been able to replace its petroleum-based counterparts. In its natural state, chitosan is rigid and brittle due to strong intermolecular hydrogen bonding between polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Understanding the Molecular-Level Interactions of Glucosamine-Glycerol Assemblies: A Model System for Chitosan Plasticization

et al. 2021

View full text Add to dashboard Cite

Glycerol is the most widely used plasticizer for the biopolymer chitosan. However, there remains a lack of understanding of the molecular-level interactions between chitosan and glycerol. Here, we describe an in-depth spectroscopic study of the intermolecular interactions between the monomeric repeating unit of chitosan, glucosamine, and the plasticizer glycerol. Infrared and nuclear magnetic resonance spectroscopy were used to probe glucosamine assembly at high and low concentrations to establish diagnostic signals for intra- and intermolecular glucosamine interactions. Systematic addition of glycerol was found to disrupt intramolecular glucosamine hydrogen bonds and promote glucosamine self-assembly. Furthermore, we observed a significant preference for glycerol binding to the amine functionality of glucosamine. These findings indicate that the plasticization of chitosan with glycerol requires a specific binding motif and likely occurs via the gel theory mechanism.

show abstract

Section: Introductionmentioning

confidence: 99%

Understanding the Molecular-Level Interactions of Glucosamine-Glycerol Assemblies: A Model System for Chitosan Plasticization

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The average of the measurements taken with micrometer from 10 different regions of the natural CPC film which obtained in three dimensions was recorded as 26.9 ± 3.1 μm. It is observed that natural CPC film has a finer structure in comparison to synthetically obtained chitosan films in earlier studies [45][46][47][48].…”

Section: Thicknessmentioning

confidence: 73%

Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier

Aylanç

Ertosun

Akyüz

et al. 2020

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

In the literature, the produced β-chitin samples are in powder or flake forms but there is no natural β-chitin based film. Also, the commercially available transdermal patches are produced from synthetic polymers. In this regard, we produced natural β-chitin-protein complex (CPC) film from the waste shells of Ensis spp. The obtained natural film was characterized by FTIR, TGA and SEM. Additionally, swelling, thickness, contact angle and antioxidant tests were done to learn more about the films. After production and characterization of the film, capsaicin, which is commonly used for pain relief was loaded into the film. The loading capacity was recorded as 5.79%. The kinetic models were studied in three different pH, then the results were fitted with Higuchi model with high correlation at pH 7.4. After considering all the obtained results, the capsaicin loaded CPC film may be an alternative candidate for transdermal patch instead of the synthetic ones.

show abstract

“…Alternatively, Rathore et al [ 39 ] have fabricated biofilms with three different concentrations of chitosan (1%, 1.5%, and 2%) impregnated with ciprofloxacin to serve as dressings for infection-prone wounds. The dressings presented good texture and biocompatibility, also benefiting from a cost-effective and easy formulation.…”

Section: Wound Dressingsmentioning

confidence: 99%

An Up-to-Date Review of Biomaterials Application in Wound Management

Niculescu

Grumezescu

2022

Polymers

View full text Add to dashboard Cite

Whether they are caused by trauma, illness, or surgery, wounds may occur throughout anyone’s life. Some injuries’ complexity and healing difficulty pose important challenges in the medical field, demanding novel approaches in wound management. A highly researched possibility is applying biomaterials in various forms, ranging from thin protective films, foams, and hydrogels to scaffolds and textiles enriched with drugs and nanoparticles. The synergy of biocompatibility and cell proliferative effects of these materials is reflected in a more rapid wound healing rate and improved structural and functional properties of the newly grown tissue. This paper aims to present the biomaterial dressings and scaffolds suitable for wound management application, reviewing the most recent studies in the field.

show abstract

Fabrication and characterization of chitosan film impregnated ciprofloxacin drug: A comparative study

Cited by 15 publications

References 17 publications

Understanding the Molecular-Level Interactions of Glucosamine-Glycerol Assemblies: A Model System for Chitosan Plasticization

Understanding the Molecular-Level Interactions of Glucosamine-Glycerol Assemblies: A Model System for Chitosan Plasticization

Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier

An Up-to-Date Review of Biomaterials Application in Wound Management

Contact Info

Product

Resources

About