Fabrication and characterization of CL-20/PEI/GO composites with enhanced thermal stability and desensitization via electrostatic self-assembly

Song, Xiaomin; Huang, Qi; Jin, Bo; Peng, Rufang

doi:10.1016/j.apsusc.2021.149933

Cited by 25 publications

(7 citation statements)

References 37 publications

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“…And there are two types of nitrogen functional groups, which are CÀ N=C (398.5 eV) and CÀ NH 2 (399.7 eV), respectively. [27,34,37]. More importantly, the amount of amino group is up to 4.70 %, which is much higher than that of our previous work.…”

Section: Resultscontrasting

confidence: 66%

“…More importantly, the amount of amino group is up to 4.70 %, which is much higher than that of our previous work. [34,35].…”

Section: Resultsmentioning

confidence: 99%

“…To solve this problem, two strategies can be utilized. One is the surface modification of explosive and the other one is the surface functionalization of coating material [24,[34][35][36].…”

Section: Introductionmentioning

confidence: 99%

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Interaction‐Enhanced Coating of Energetic Material: A Generally Applicable Method for the Desensitization

Song

Huang

Zhang

et al. 2022

Propellants Explo Pyrotec

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Inspired by the better desensitizing effect introduced by enhanced interaction, ammonium formate (Am) was utilized to modify graphene oxide (GO) and the functional graphene oxide (Am−GO) was obtained in this work, which was endowed with more amino groups and completely positive charge. Due to the modification and corresponding enhanced interaction, the impact sensitivity and friction sensitivity of HMX/Am−GO can be desensitized to 40 J and 192 N, respectively. To further desensitize the friction sensitivity, graphite (G) was utilized to replace part of Am−GO. And HMX/Am−GO/G was endowed with 40 J and 360 N of impact sensitivity and friction sensitivity respectively, which is the best desensitizing effect of HMX to our best knowledge. Furthermore, CL‐20 and DNTF were coated by the same coating, which also can be desensitized with the best effect. In addition, because the coating process is performed in water at room temperature, this desensitization is environment‐friendly and benefit for the large scale of production. This work demonstrates the improved desensitizing effect with enhanced interaction and provides a potential general applicable method for desensitization.

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Section: Resultscontrasting

confidence: 66%

“…More importantly, the amount of amino group is up to 4.70 %, which is much higher than that of our previous work. [34,35].…”

Section: Resultsmentioning

confidence: 99%

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Interaction‐Enhanced Coating of Energetic Material: A Generally Applicable Method for the Desensitization

Song

Huang

Zhang

et al. 2022

Propellants Explo Pyrotec

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“…The molecular weights and the amount of branches can be designed to possess different physical properties [ 218 ]. PEI can condense with nucleic acids through electrostatic self-assembly to form stable nano-sized particles [ 219 ]. PEI has a high buffering capacity and promotes cellular uptake and endosomal escape through the proton sponge effect.…”

Section: Modifications Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy

Zhang

et al. 2022

Molecules

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Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are considered to be one of the most efficient drug delivery platforms. Due to the prominent advantages, such as long circulation time, slow drug release, reduced toxicity, high transfection efficiency, and endosomal escape capacity, such synthetic nanoparticles have been widely used for carrying genetic therapeutics, particularly nucleic acids that can be applied in the treatment for various diseases, including congenital diseases, cancers, virus infections, and chronic inflammations. Despite great merits and multiple successful applications, many extracellular and intracellular barriers remain and greatly impair delivery efficacy and therapeutic outcomes. As such, the current state of knowledge and pitfalls regarding the gene delivery and construction of LBNPs will be initially summarized. In order to develop a new generation of LBNPs for improved delivery profiles and therapeutic effects, the modification strategies of LBNPs will be reviewed. On the basis of these developed modifications, the performance of LBNPs as therapeutic nanoplatforms have been greatly improved and extensively applied in immunotherapies, including infectious diseases and cancers. However, the therapeutic applications of LBNPs systems are still limited due to the undesirable endosomal escape, potential aggregation, and the inefficient encapsulation of therapeutics. Herein, we will review and discuss recent advances and remaining challenges in the development of LBNPs for nucleic acid-based immunotherapy.

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“…9 However, it has been found that ε-HNIW possesses high mechanical sensitivity, which limits its potentiality for several energetic applications. 10 In this case, numerous approaches such as promoting crystal quality, 11 coating or doping with insensitive materials, 12 and cocrystallizing with other molecules 13 have been taken to tune this problem. Although these methods can reduce the sensitivity of HNIW, they have some shortcomings, such as energy loss and low applicability.…”

Section: Introductionmentioning

confidence: 99%

Host–guest energetic materials: a promising strategy of incorporating small insensitive molecule into the lattice cavities of 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane to enhance the safety on the premise of maintaining the excellent energy density

et al. 2022

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Fabrication and characterization of CL-20/PEI/GO composites with enhanced thermal stability and desensitization via electrostatic self-assembly

Cited by 25 publications

References 37 publications

Interaction‐Enhanced Coating of Energetic Material: A Generally Applicable Method for the Desensitization

Interaction‐Enhanced Coating of Energetic Material: A Generally Applicable Method for the Desensitization

Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy

Host–guest energetic materials: a promising strategy of incorporating small insensitive molecule into the lattice cavities of 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane to enhance the safety on the premise of maintaining the excellent energy density

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