Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering

Zahedi, Elahe; Esmaeili, Akbar; Eslahi, Niloofar; Shokrgozar, Mohammad Ali; Simchi, A.

doi:10.3390/md17010027

Cited by 76 publications

(34 citation statements)

References 51 publications

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“…The core was composed of PEO/herb (D~209 nm) and the shell consisted of PCL/chitosan/keratin (thickness~91 nm). The authors observed that the co-axial electrospun core-shell structure improved tensile strength (~5 MPa) and elongation, where keratin positively contributed to the tensile strength, but reduced the elongation [284].…”

Section: Chitosanmentioning

confidence: 99%

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Donato

Mija

2019

Polymers

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Among the biopolymers from animal sources, keratin is one the most abundant, with a major contribution from side stream products from cattle, ovine and poultry industry, offering many opportunities to produce cost-effective and sustainable advanced materials. Although many reviews have discussed the application of keratin in polymer-based biomaterials, little attention has been paid to its potential in association with other polymer matrices. Thus, herein, we present an extensive literature review summarizing keratin’s compatibility with other synthetic, biosynthetic and natural polymers, and its effect on the materials’ final properties in a myriad of applications. First, we revise the historical context of keratin use, describe its structure, chemical toolset and methods of extraction, overview and differentiate keratins obtained from different sources, highlight the main areas where keratin associations have been applied, and describe the possibilities offered by its chemical toolset. Finally, we contextualize keratin’s potential for addressing current issues in materials sciences, focusing on the effect of keratin when associated to other polymers’ matrices from biomedical to engineering applications, and beyond.

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Section: Chitosanmentioning

confidence: 99%

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Donato

Mija

2019

Polymers

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“…Other natural polymers for modification of PCL nanofibers included whey protein [62], hyaluronic acid [24], keratin [28,63], chitosan [28], fibrinogen [64], or gum arabic, and a corn protein zein [65]. These natural polymers were blended with PCL in the electrospinning solution.…”

Section: Nanofibers From Synthetic Degradable Polymersmentioning

confidence: 99%

“…In co-axial electrospinning, hybrid nanofibers with a core-shell architecture are created by spinning of two different solutions filled into outer and inner compartments of a co-axial syringe. Finally, an electrospun polymer can be secondarily coated with other polymers or bioactive substances [22,[26][27][28] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

Bačáková¹,

Zikmundová²,

Pajorová³

et al. 2020

Applications of Nanobiotechnology

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Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group.

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“…Keratin was also a component of core-shell nanofibers, prepared by coaxial electrospinning of chitosan, PCL and keratin with Aloe vera extracts encapsulated inside the polymer nanofibers. This construct increased the adhesion and growth of L929 fibroblasts and was intended for wound healing applications [128]. Importantly, keratin was a component of bilayer scaffolds for skin tissue engineering, composed of human hair keratin/ chitosan nanofiber mat and gelatin methacrylate (GelMA) hydrogel.…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 99%

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Bačáková¹,

Pajorová²,

Zikmundová³

et al. 2020

Current and Future Aspects of Nanomedicine

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Nanofibrous scaffolds belong to the most suitable materials for tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. This chapter is focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is the largest and vitally important organ in the human body. Nanofibrous meshes can serve as substrates for adhesion, growth and differentiation of skin and stem cells, and also as an antimicrobial and moistureretaining barrier. These meshes have been prepared from a wide range of synthetic and nature-derived polymers. This chapter is focused on the use of nature-derived polymers. These polymers have good or limited degradability in the human tissues, which depends on their origin and on the presence of appropriate enzymes in the human tissues. Non-degradable and less-degradable polymers are usually produced in bacteria, fungi, algae, plants or insects, and include, for example, cellulose, dextran, pullulan, alginate, pectin and silk fibroin. Well-degradable polymers are usually components of the extracellular matrix in the human body or at least in other verte brates, and include collagen, elastin, keratin and hyaluronic acid, although some polymers produced by non-vertebrate organisms, such as chitosan or poly(3-hydroxybutyrate-co-3-hydroxyvalerate), are also degradable in the human body.Current and Future Aspects of Nanomedicine 2 microbial infection, and at the same time, they can keep appropriate moisture and gas exchange at the wound site.Nanofibrous scaffolds for skin tissue engineering have been fabricated from a wide range of synthetic and nature-derived polymers, which can be either biostable or degradable within the human body. Biostable synthetic polymers used in nanofiber-based skin regenerative therapies include, for example, polyurethane [2], polydimethylsiloxane [3], polyethylene terephthalate [4], polyethersulfone [5], and also hydrogels such as poly(acrylic acid) (PAA, [6]), poly(methyl methacrylate) (PMMA, [7]), and poly[di(ethylene glycol) methyl ether methacrylate] (PDEGMA, [8]). Degradable synthetic polymers typically include poly(ε-caprolactone) (PCL, [9]) and its copolymers with polylactides (PLCL, [10]), polylactides (PLA, [11]) and their copolymers with polyglycolides (PLGA, [12]), and also so-called auxiliary polymers, such as poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO, [13]) or poly(vinyl alcohol) (PVA, [14]), which facilitated the electrospinning process and improved the mechanical properties and wettability of the chief polymer. However, the synthetic polymers, although they are well-chemically defined and tailorable, are often bioinert, hydrophobic and thus not promoting cell adhesion, and also not well-adhering to the wound site. Therefore, they need to be combined with other bioactive substances, particularly nature-derived polymers.This chapter is focused on nature-derived polymers used for fabrication of nanofibrous scaffolds for skin tissue engineering and wound healing. The advantages of...

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Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering

Cited by 76 publications

References 51 publications

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

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