Fabrication and characterization of hydroxyapatite-strontium/polylactic acid composite for potential applications in bone regeneration

Oyedeji, Ayodeji Nathaniel; Obada, David O.; Dauda, Mohammed; Kuburi, L.S.; Csáki, Štefan; Veverka, Jakub

doi:10.1007/s00289-022-04541-3

Cited by 6 publications

(2 citation statements)

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“…Our results on the polymer blend filaments degradation showed a non-significant mass loss within 3% over the time period investigated in this study, indicating that their degradation will take a longer time. PLA degradation is well described [ 50 ], but PLLA/PCL/PHBV is a new polymer blend. The longer-term degradation of the blend scaffolds will be studied in future work to show how the concentrations of PCL and PHBV would affect their degradation rate.…”

Section: Discussionmentioning

confidence: 99%

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Promotion of In Vitro Osteogenic Activity by Melt Extrusion-Based PLLA/PCL/PHBV Scaffolds Enriched with Nano-Hydroxyapatite and Strontium Substituted Nano-Hydroxyapatite

et al. 2023

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Bone tissue engineering has emerged as a promising strategy to overcome the limitations of current treatments for bone-related disorders, but the trade-off between mechanical properties and bioactivity remains a concern for many polymeric materials. To address this need, novel polymeric blends of poly-L-lactic acid (PLLA), polycaprolactone (PCL) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) have been explored. Blend filaments comprising PLLA/PCL/PHBV at a ratio of 90/5/5 wt% have been prepared using twin-screw extrusion. The PLLA/PCL/PHBV blends were enriched with nano-hydroxyapatite (nano-HA) and strontium-substituted nano-HA (Sr-nano-HA) to produce composite filaments. Three-dimensional scaffolds were printed by fused deposition modelling from PLLA/PCL/PHBV blend and composite filaments and evaluated mechanically and biologically for their capacity to support bone formation in vitro. The composite scaffolds had a mean porosity of 40%, mean pores of 800 µm, and an average compressive modulus of 32 MPa. Polymer blend and enriched scaffolds supported cell attachment and proliferation. The alkaline phosphatase activity and calcium production were significantly higher in composite scaffolds compared to the blends. These findings demonstrate that thermoplastic polyesters (PLLA and PCL) can be combined with polymers produced via a bacterial route (PHBV) to produce polymer blends with excellent biocompatibility, providing additional options for polymer blend optimization. The enrichment of the blend with nano-HA and Sr-nano-HA powders enhanced the osteogenic potential in vitro.

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Section: Discussionmentioning

confidence: 99%

“…These composite scaffolds have been used in BTE, indicating an enhancement of osteogenic cell differentiation and reduction of the osteoclastic activity. Only a few reports propose strontium-substituted HA in pure PLA-based composites for potential BTE applications [ 49 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%