2006
DOI: 10.1039/b512179e
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Fabrication and characterization of poly(methylmethacrylate) microfluidic devices bonded using surface modifications and solvents

Abstract: The fabrication of polymer microchips allows inexpensive, durable, high-throughput and disposable devices to be made. Poly(methylmethacrylate) (PMMA) microchips have been fabricated by hot embossing microstructures into the substrate followed by bonding a cover plate. Different surface modifications have been examined to enhance substrate and cover plate adhesion, including: air plasma treatment, and both acid catalyzed hydrolysis and aminolysis of the acrylate to yield carboxyl and amine-terminated PMMA surfa… Show more

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Cited by 268 publications
(225 citation statements)
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“…Intermediate adhesive layers have been proposed, but can interact with the fluid passing through the microfluidic channels. Surface modification and solvent-assisted bonding (Brown et al 2006) which can change surface shape but usually involve highly toxic chemicals (chloromethane, dichloromethane, chloroform) are other proposed methods. Furthermore, both methods can lead to clogging of the channels (Lin et al 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Intermediate adhesive layers have been proposed, but can interact with the fluid passing through the microfluidic channels. Surface modification and solvent-assisted bonding (Brown et al 2006) which can change surface shape but usually involve highly toxic chemicals (chloromethane, dichloromethane, chloroform) are other proposed methods. Furthermore, both methods can lead to clogging of the channels (Lin et al 2007).…”
Section: Introductionmentioning
confidence: 99%
“…The PS-b-PMMA substrates were rinsed with 50/50 v/v IPA/DI for 1 min followed by immersion in DMSO for 5 min and 1−5 min immersion in 2−5% vol % ED in DMSO to functionalize the surface PMMA regions of the substrate with amine functional groups. 58 The standard treatment of ED was for 5 min in 5 vol % ED in DMSO solution. Any deviations are clearly stated in the text.…”
Section: ■ Materials and Methodsmentioning
confidence: 99%
“…The PT PMMA surface showed relatively uniform adsorption of proteins in contrast to the plain PMMA surface. It has been shown previously that the oxygen plasma treatment created carboxylic groups and other reactive radicals on the PMMA surface which could allow the binding of the proteins [35].…”
Section: Blocking Effects Measured By Fluorescence Microscopymentioning
confidence: 99%