Fabrication and characterization of POM/ZrO2/silk fibroin composite scaffolds

Teimouri, Abbas; Ghorbanian, Leila; Salavati, Hossien; Chermahini, Alireza Najafi

doi:10.1016/j.matlet.2015.05.064

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…The foregoing studies mainly involved the use of calcium phosphate-based bioceramics with bone-like properties to reproduce the bone-graft activities of zirconia scaffolds. However, Teimouri et al, in 2015 established the use of inorganic polyoxometalates (POMs) with a unique biological property to promote the biological activity of zirconia by constructing a POM/zirconia/silk fibroin nanocomposite framework via the freeze-drying method [60]. The in vitro bioactive behaviour of the POM/zirconia/silk fibroin in simulated body fluid (SBF) was examined, and a uniform distribution of fibroblast cells on the POM/zirconia/silk fibroin composite scaffold was observed.…”

Section: Freeze-drying Techniquementioning

confidence: 99%

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

et al. 2021

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The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds.

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Section: Freeze-drying Techniquementioning

confidence: 99%

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

et al. 2021

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“…Herein, the size of the porogen controlled the pore size (100–300 μm) of the scaffold, having porosity of about 90–96%. Similarly, polyoxometalates (POM)/ZrO 2 /silk fibroin nanocomposite scaffolds have been fabricated by a freeze-drying method . These composites have supported considerable in vitro bone activity.…”

Section: Silk-based Nanocompositesmentioning

confidence: 99%

“…Similarly, polyoxometalates (POM)/ZrO 2 /silk fibroin nanocomposite scaffolds have been fabricated by a freeze-drying method. 91 These composites have supported considerable in vitro bone activity. CaP/silk composite scaffolds prepared by the freezedrying method showed osteogenic properties.…”

Section: Silk-based Nanocompositesmentioning

confidence: 99%

Comprehensive Review on Silk at Nanoscale for Regenerative Medicine and Allied Applications

Mehrotra

Chouhan

Konwarh

et al. 2019

ACS Biomater. Sci. Eng.

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Materials at the nanoscale offer numerous avenues to be explored and exploited in diverse realms. Among others, proteinaceous biomaterials such as silk hold immense prospects in the domain of nanoengineering. Silk offers a unique combination of desirable facets like biocompatibility; extraordinary mechanical properties, such as elongation, elasticity, toughness, and modulus; and tunable biodegradability which are far better than most naturally occurring and engineered materials. Much of these properties are due to the molecular structure of the silk protein and it is self-assembly into hierarchical structures. Taking advantage of the hierarchical assembly, a large number of fabrication strategies have now emerged that allow the tailoring of silk structure of at the nanoscale. Harnessing the favorable properties of silk, such methods offer a promising direction toward producing structurally and functionally optimized silk nanomaterials. This review discusses the critical structure–property relationship in silk that occurs at the nanoscale and also aims to bring out the recent status in the approaches for fabrication, characterization, and the gamut of applications of various silk-based nanomaterials (nanoparticles, nanofibers, and nanocomposites) in the niche of translational research. Harnessing the favorable nanostructure of silk, the review also takes into account the impetus of silk in avant-garde applications such as chemo-biosensing, energy harvesting, microfluidics, and environmental applications.

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“…Teimouri and co-workers 29 have disclosed an efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles by the condensation of different aromatic carboxylic acids and benzoyl hydrazides in the presence of natural alumina, alumina sulfuric acid (ASA), nanoalumina and nano-alumina sulfuric acid (nano-ASA) as a solid heterogeneous catalyst. These reactions were performed under microwave irradiation (dedicated microwave oven) and solvent-free conditions (Scheme 3).…”

Section: Synthesis Of 25-disubstituted 134-oxadiazolesmentioning

confidence: 99%

“…Teimouri et al 37 have discovered a condensation of different aldehydes, amines and trimethylsilyl cyanides for the synthesis of α-aminonitriles derivatives using natural alumina, alumina sulfuric acid (ASA), nano-γ-alumina, nano-alumina sulfuric acid (nano-ASA) (Scheme 10). All these reactions were performed under microwave irradiation (dedicated microwave oven) without the use of any organic solvents.…”

Section: Strecker Reactionmentioning

confidence: 99%

Alumina sulfuric acid (ASA), tungstate sulfuric acid (TSA), molybdate sulfuric acid (MSA) and xanthan sulfuric acid (XSA) as solid and heterogeneous catalysts in green organic synthesis: a review

Vekariya¹,

Patel²

2015

Arkivoc

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Fabrication and characterization of POM/ZrO2/silk fibroin composite scaffolds

Cited by 9 publications

References 28 publications

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Comprehensive Review on Silk at Nanoscale for Regenerative Medicine and Allied Applications

Alumina sulfuric acid (ASA), tungstate sulfuric acid (TSA), molybdate sulfuric acid (MSA) and xanthan sulfuric acid (XSA) as solid and heterogeneous catalysts in green organic synthesis: a review

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