Fabrication and characterization of shape memory polyurethane porous scaffold for bone tissue engineering

Abstract

Tissue engineering is a promising alternative for treating bone defects. However, improvements in scaffold design are needed to precisely match the irregular boundaries of bone defects as well as facilitate clinical application. In this study, a shape memory polyurethane scaffold was fabricated using a salt-leaching-phase inverse technique. Different sizes of salts were used to obtain scaffolds with different pore sizes. Scanning electron microscope, X-ray photoelectron spectroscopy, and X-ray micro-computed tomography analysis confirmed that three-dimensional porous polyurethane scaffolds were obtained. The mechanical properties and biocompatibility of the scaffolds were analyzed by compression testing, thermal mechanical analysis, and cell experiments with osteosarcoma MG-63 cells. The results revealed that the scaffolds had good mechanical properties and shape memory properties for bone repair, and also had the ability to promote cell proliferation. Thus, this scaffold design has good prospects for application to bone tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1132-1137, 2017.

Rational design of biodegradable thermoplastic polyurethanes for tissue repair

“…PU-based SMPs have been developed for tissue engineering because of their good biocompatibility and elasticity and tailorable transition temperatures (Tg and Tm) [ 104 ]. Most reported tissue-engineered scaffolds based on SMPs are triggered by a thermal stimulus, in which their shape recovery temperatures are near or slightly higher than body temperature [ [105] , [106] , [107] , [108] ]. The shape memory function of the PU-based SMP is majorly attributed to soft segment alteration.…”

The effect of hydroxyapatite nanoparticles on mechanical behavior and biological performance of porous shape memory polyurethane scaffolds

“…First, NaCl particles with size between 200 and 100 meshes were fabricated according to the method described previously with minor modification . Briefly, NaCl was grinded in the Ball mill (Pulverisette 6, Fritsch Japan Co., Ltd, Japan) at 300 rpm for 5 min and filtered by using two sieves having 200 mesh and 100 mesh.…”

Research Progress of Shape Memory Polymer and 4D Printing in Biomedical Application

“…This study provides a simple strategy for designing mul-tifunctional tissue scaffolds for the treatment of bone defects. Yu et al [211] synthesized a novel shape memory polyurethane (SMPU) by diphenylmethane 4, 4,-diisocyanate (MDI), adipic acid, ethylene glycol, ethylene oxide (EO), polypropylene oxide (PO), 1, 4-butanediol. Further, a series of porous SMPU-based scaffolds were prepared by the salt particle leaching method.…”

“…f) SEM images of SMPU scaffolds with different pore sizes, and cell proliferation and adhesion on the surface of scaffolds. Reproduced with permission [211]. Copyright 2022, John Wiley and Sons.…”