Fabrication and characterization of zein/bioactive glass deposited on pretreated magnesium via electrophoretic deposition

Ahmed, Yusra; Nawaz, Aneeqa; Virk, Ranjot Singh; Wadood, Abdul; Rehman, Muhammad Atiq Ur

doi:10.1002/ces2.10066

Cited by 16 publications

(7 citation statements)

References 44 publications

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“…Moreover, zein dissolved completely during the suspension preparation, which may have contributed to the formation of films (Figure 2b). However, slight variations in the coating homogeneity have been observed among different researchers, as well as in the current study, which is possibly due to the difference in particle size and concentration of BG along with the variations in EPD parameters [17,18,24]. The typical porous structure of zein was observed in this study, which is consistent with the research by Zhao et al [18].…”

Section: Epd Of Zein/bg On Mgsupporting

confidence: 91%

“…However, successful EPD of zein/BG on the Mg substrate is a challenging task due to the fast degradation of Mg. To control the degradation rate of Mg, Zhao et al [22] and Höhlinger et al [23] employed different pre-treatment reagents. Accordingly, this research work is comprised of the pre-treatment of Mg with the phosphoric acid (H 3 PO 4 ) and di-ammonium hydrogen phosphate (DAHP), following the previous studies by Ahmed et al [24].…”

Section: Introductionmentioning

confidence: 99%

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Zein/Bioactive Glass Coatings with Controlled Degradation of Magnesium under Physiological Conditions: Designed for Orthopedic Implants

Rehman

2020

Prosthesis

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Magnesium and its alloys are widely considered as temporary bio-implants owing to their mechanical properties and biocompatibility. However, the high corrosion rates and degradation in the physiological environment restrict the practical application of Mg as a biomedical device. Therefore, in this study, Zein/45S5 bioactive glass (BG) coatings were deposited via electrophoretic deposition (EPD) on pretreated pure magnesium (Mg) substrates, which controls the rapid degradation of magnesium. The set of EPD parameters was first optimized on stainless steel (SS) and then the optimum EPD parameters were applied to obtain zein/BG composite coatings on Mg substrates. The morphology of the obtained coatings was studied by scanning electron microscopy (SEM). SEM results showed that both zein and BG were successfully deposited on the surface of the Mg substrate. Electrochemical measurements consisting of open circuit potential (OCP), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization confirmed that the corrosion resistance of Mg improved after the deposition of zein/BG coatings. The in-vitro bioactivity study was carried out by immersing the zein/BG coatings in simulated body fluid for 3, 7, and 21 days. SEM, energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy results elucidated that the hydroxyapatite layer developed after 21 days of immersion in SBF, which confirmed the bone binding ability of the coatings.

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Section: Epd Of Zein/bg On Mgsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Zein/Bioactive Glass Coatings with Controlled Degradation of Magnesium under Physiological Conditions: Designed for Orthopedic Implants

Rehman

2020

Prosthesis

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“…Different zein-based coatings are being developed. In the field of orthopedics, zein is used as coating on SS, Ti, and Mg implants, and as a fixation device [140][141][142]. As discussed in Section 2.4 in case of problems associated with metallic implants (e.g., toxic ion release, corrosion, etc.)…”

Section: Epd Of Zein Based Coatingsmentioning

confidence: 99%

A Brief Insight to the Electrophoretic Deposition of PEEK-, Chitosan-, Gelatin-, and Zein-Based Composite Coatings for Biomedical Applications: Recent Developments and Challenges

et al. 2021

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Electrophoretic deposition (EPD) is a powerful technique to assemble metals, polymer, ceramics, and composite materials into 2D, 3D, and intricately shaped implants. Polymers, proteins, and peptides can be deposited via EPD at room temperature without affecting their chemical structures. Furthermore, EPD is being used to deposit multifunctional coatings (i.e., bioactive, antibacterial, and biocompatible coatings). Recently, EPD was used to architect multi-structured coatings to improve mechanical and biological properties along with the controlled release of drugs/metallic ions. The key characteristics of EPD coatings in terms of inorganic bioactivity and their angiogenic potential coupled with antibacterial properties are the key elements enabling advanced applications of EPD in orthopedic applications. In the emerging field of EPD coatings for hard tissue and soft tissue engineering, an overview of such applications will be presented. The progress in the development of EPD-based polymeric or composite coatings, including their application in orthopedic and targeted drug delivery approaches, will be discussed, with a focus on the effect of different biologically active ions/drugs released from EPD deposits. The literature under discussion involves EPD coatings consisting of chitosan (Chi), zein, polyetheretherketone (PEEK), and their composites. Moreover, in vitro and in vivo investigations of EPD coatings will be discussed in relation to the current main challenge of orthopedic implants, namely that the biomaterial must provide good bone-binding ability and mechanical compatibility.

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“…EPD involves the movement and deposition of charged particles from the colloidal suspension in the presence of an electric field. EPD is a cost-effective process conducted at room temperature [ 32 ]. Numerous studies have been conducted on zein/bioactive glasses composite coatings deposited via EPD [ 32 , 33 ], but deposition of zein/MBGNs doped with metallic ions via EPD is a new approach to study the synergetic effect of dual ions.…”

Section: Introductionmentioning

confidence: 99%

“…EPD is a cost-effective process conducted at room temperature [ 32 ]. Numerous studies have been conducted on zein/bioactive glasses composite coatings deposited via EPD [ 32 , 33 ], but deposition of zein/MBGNs doped with metallic ions via EPD is a new approach to study the synergetic effect of dual ions. Evidently, we are the first to present a work on the development of zein/Ag-Sr doped MBGN coatings deposited on 316L SS via EPD.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications

et al. 2022

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Implants are used to replace damaged biological structures in human body. Although stainless steel (SS) is a well-known implant material, corrosion of SS implants leads to the release of toxic metallic ions, which produce harmful effects in human body. To prevent material degradation and its harmful repercussions, these implanted materials are subjected to biocompatible coatings. Polymeric coatings play a vital role in enhancing the mechanical and biological integrity of the implanted devices. Zein is a natural protein extracted from corn and is known to have good biocompatibility and biodegradability. In this study, zein/Ag-Sr doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were deposited on SS substrates via electrophoretic deposition (EPD) at different parameters. Ag and Sr ions were added to impart antibacterial and osteogenic properties to the coatings, respectively. In order to examine the surface morphology of coatings, optical microscopy and scanning electron microscopy (SEM) were performed. To analyze mechanical strength, a pencil scratch test, bend test, and corrosion and wear tests were conducted on zein/Ag-Sr doped MBGN coatings. The results show good adhesion strength, wettability, corrosion, and wear resistance for zein/Ag-Sr doped MBGN coatings as compared to bare SS substrate. Thus, good mechanical and biological properties were observed for zein/Ag-Sr doped MBGN coatings. Results suggested these zein/Ag-Sr MBGNs coatings have great potential in bone regeneration applications.

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Fabrication and characterization of zein/bioactive glass deposited on pretreated magnesium via electrophoretic deposition

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 44 publications

Zein/Bioactive Glass Coatings with Controlled Degradation of Magnesium under Physiological Conditions: Designed for Orthopedic Implants

Zein/Bioactive Glass Coatings with Controlled Degradation of Magnesium under Physiological Conditions: Designed for Orthopedic Implants

A Brief Insight to the Electrophoretic Deposition of PEEK-, Chitosan-, Gelatin-, and Zein-Based Composite Coatings for Biomedical Applications: Recent Developments and Challenges

Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications

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