Fabrication and evaluation of a biodegradable cohesive plug based on reconstituted collagen/γ‐polyglutamic acid

Hsu, Fu‐Yin; Cheng, Yayun; Tsai, Shih Chang; Tsai, Wei‐Bor

doi:10.1002/jbm.b.31679

Cited by 10 publications

(6 citation statements)

References 31 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has seen some application in soft tissue engineering within cross‐linked hydrogels . Attempts to equip this polyamide with characteristics suited to tissue engineering have been based on blending with natural (collagen and chitosan) and synthetic polymers (PLA, PLGA, and PCL) however, research has been limited due to the low availability of γ ‐PGA.…”

Section: Naturally‐occurring Polymersmentioning

confidence: 99%

Polymers for medical and tissue engineering applications

Ozdil

Aydın

2014

J. Chem. Technol. Biotechnol.

142

View full text Add to dashboard Cite

Recent decades have seen great advancements in medical research into materials, both natural and synthetic, that facilitate the repair and regeneration of compromised tissues through the delivery and support of cells and/or biomolecules. Biocompatible polymeric materials have become the most heavily investigated materials used for such purposes. Naturally‐occurring and synthetic polymers, including their various composites and blends, have been successful in a range of medical applications, proving to be particularly suitable for tissue engineering (TE) approaches. The increasing advances in polymeric biomaterial research combined with the developments in manufacturing techniques have expanded capabilities in tissue engineering and other medical applications of these materials. This review will present an overview of the major classes of polymeric biomaterials, highlight their key properties, advantages, limitations and discuss their applications. © 2014 Society of Chemical Industry

show abstract

Section: Naturally‐occurring Polymersmentioning

confidence: 99%

Polymers for medical and tissue engineering applications

Ozdil

Aydın

2014

J. Chem. Technol. Biotechnol.

142

View full text Add to dashboard Cite

show abstract

“…This periodicity, or D-banding pattern, ranges from 64 to 67 nm, depending on the tissue or organ . The D-pattern is reported to be important for several cellular and biological processes such as bone matrix mineralization, cell morphology, and hemostasis. − Bone mineral crystals first form in the gaps of the collagen fibrils . The gap interface has been associated with primary mineralization events in the early stages of in vivo bone formation .…”

Section: Introductionmentioning

confidence: 99%

Poly(ε-caprolactone) Nanofibers with a Self-Induced Nanohybrid Shish-Kebab Structure Mimicking Collagen Fibrils

et al. 2013

View full text Add to dashboard Cite

A three-dimensional structure consisting of poly(ε-caprolactone) (PCL) nanofibers covered by periodically spaced PCL crystal lamellae, a self-induced nanohybrid shish-kebab (SINSK) structure, was created using electrospinning followed by a self-induced crystallization. The resulting structure that resembles the nanotopography of natural collagen nanofibrils in the extracellular matrix (ECM) of human tissues could serve as a tissue engineering scaffold. The formation mechanism of the self-induced shish-kebab structure was investigated with real-time observation of the crystallization process. Electrospun polylactic acid (PLA)/PCL nanofibers were also employed as shish elements to study the effects of different shish materials. The results show that the geometric dimensions of the shish-kebabs are highly related to the initial concentration of PCL solution. The shish material played an important role in the creation of shish-kebab structure. Cell assays with NIH 3T3 ECACC fibroblasts suggest that the nanotopography of the nanofiber surface with kebab crystals that mimic collagen fibrils facilitated the cell attachment and spreading of 3T3 fibroblasts cells.

show abstract

“…The number of cells increased with increasing kebab crystal size. 28 So, 0.5 wt % PCL solution was applied to form SK structure in this study. SEM images (Figure 2c,d) showed the periodic kebab pattern covering the whole nanofiber, which is consistent with the previous study.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, different concentrations of PCL solution (0, 0.01, 0.05, 0.1, and 0.5 wt %) were applied to form kebab crystals on nanofibers, and it was found that the kebab crystals became larger with increasing concentration of PCL solution. The number of cells increased with increasing kebab crystal size . So, 0.5 wt % PCL solution was applied to form SK structure in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Collagen nanofibers, which make up the main structure of the ECM, all consist of a triple-helical structure of wound alpha chains . This structure is proved to be crucial for bone collagen mineralization, cell behaviors and hemostasis. − Much effort has been made to produce scaffolds with surface topography as it is an important factor in determining cellular response. Moderate surface nanoroughness could modulate and facilitate cell adhesion, migration, and proliferation compared with a smooth surface .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Controlled Delivery of Growth Factor by Hierarchical Nanostructured Core–Shell Nanofibers for the Efficient Repair of Critical-Sized Rat Calvarial Defect

Huang

Yang

Zhou

et al. 2020

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Electrospun nanofibers have received much attention as bone tissue-engineered scaffolds for their capacity to mimic the structure of natural extracellular matrix (ECM). Most studies have reproduced nanofibers with smooth surface for tissue engineering. This is quite different from the triple-helical nanotopography of natural collagen nanofibrils. In this study, hierarchical nanostructures were coated on the surface of drug-loaded core–shell nanofibers to mimic natural collagen nanofibrils. The nanoshish-kebab (SK) structure was decorated regularly on the surface of the nanofibers, and the inner-loaded bone morphogenetic protein 2 (BMP2) exhibited a gentle release pattern, similar to a zero-order release pattern in kinetics. The in vitro study also showed that the SK structure could accelerate cell proliferation, attachment, and osteogenic differentiation. Four groups of scaffolds were implanted in vivo to repair critical-sized rat calvarial defects: (1) PCL/PVA (control); (2) SK-PCL/PVA; (3) PCL/PVA-BMP2; and (4) SK-PCL/PVA-BMP2. Much more bone was formed in the SK-PCL/PVA group (24.57 ± 3.81%) than in the control group (1.21 ± 0.23%). The BMP2-loaded core–shell nanofibers with nanopatterned structure (SK-PCL/PVA-BMP2) displayed the best repair efficacy (76.38 ± 4.13%), followed by the PCL/PVA-BMP2 group (39.86 ± 5.74%). It was believed that the hierarchical nanostructured core–shell nanofibers could promote osteogeneration and that the SK structure showed synergistic ability with nanofiber-loaded BMP2 in vivo for bone regeneration. Thus, this BMP2-loaded core–shell nanofiber scaffold with hierarchical nanostructure holds great potential for bone tissue engineering applications.

show abstract

Fabrication and evaluation of a biodegradable cohesive plug based on reconstituted collagen/γ‐polyglutamic acid

Cited by 10 publications

References 31 publications

Polymers for medical and tissue engineering applications

Polymers for medical and tissue engineering applications

Poly(ε-caprolactone) Nanofibers with a Self-Induced Nanohybrid Shish-Kebab Structure Mimicking Collagen Fibrils

Controlled Delivery of Growth Factor by Hierarchical Nanostructured Core–Shell Nanofibers for the Efficient Repair of Critical-Sized Rat Calvarial Defect

Contact Info

Product

Resources

About