Fabrication and evaluation of evanescent wave absorption based polyaniline-cladding modified fiber optic urea biosensor

Botewad, Sunil N.; Pahurkar, V. G.; Muley, G.G.

doi:10.1016/j.yofte.2017.11.002

Cited by 32 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fiber optic biosensors have been exploited as sensor platforms for a variety of applications such as sensing glucose 35 – 42 , sucrose 36 , heavy metal ions such as lead, copper, cobalt, cadmium 43 – 45 , amino acids 46 , cholesterol 47 , triacylglycerides 48 , urea 49 , ascorbic acid 50 , DNA 34 , 51 , proteins including thrombin 52 – 54 , cancer biomarkers 55 , 56 and cytokeratin 57 , 58 , antibodies 59 , bacterial 60 – 62 and mammalian cells 63 , 64 .…”

Section: Introductionmentioning

confidence: 99%

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Bekmurzayeva

Ashikbayeva

Myrkhiyeva

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Increased level of CD44 protein in serum is observed in several cancers and is associated with tumor burden and metastasis. Current clinically used detection methods of this protein are time-consuming and use labeled reagents for analysis. Therefore exploring new label-free and fast methods for its quantification including its detection in situ is of importance. This study reports the first optical fiber biosensor for CD44 protein detection, based on a spherical fiber optic tip device. The sensor is easily fabricated from an inexpensive material (single-mode fiber widely used in telecommunication) in a fast and robust manner through a CO2 laser splicer. The fabricated sensor responded to refractive index change with a sensitivity of 95.76 dB/RIU. The spherical tip was further functionalized with anti-CD44 antibodies to develop a biosensor and each step of functionalization was verified by an atomic force microscope. The biosensor detected a target of interest with an achieved limit of detection of 17 pM with only minor signal change to two control proteins. Most importantly, concentrations tested in this work are very broad and are within the clinically relevant concentration range. Moreover, the configuration of the proposed biosensor allows its potential incorporation into an in situ system for quantitative detection of this biomarker in a clinical setting.

show abstract

Section: Introductionmentioning

confidence: 99%

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Bekmurzayeva

Ashikbayeva

Myrkhiyeva

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Polyaniline (PANI) possesses exceptional structural properties due to the inception of nitrogen heteroatom between the phenyl rings along the backbone. It has attracted much attention in numerous sensing applications such as gas detection 5 , ascorbic acid detection 6 , multi-electrode sensor arrays 7 , coatings for quartz crystal microbalance sensors 8 , chemiresistors using single-walled carbon nanotubes 9 and as modified cladding in optical fiber sensors 10 .…”

Section: Introductionmentioning

confidence: 99%

Highly Luminescent Ternary Nanocomposite of Polyaniline, Silver Nanoparticles and Graphene Oxide Quantum Dots

Shokry

Khalil

Ibrahim

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Quantum dots (QDs) with photostability show a potential application in optical sensing and biological imaging. In this work, ternary nanocomposite (NC) of high fluorescent polyaniline (PANI)/2-acrylamido-2-methylpropanesulfonic acid (AMPSA) capped silver nanoparticles (NPs)/graphene oxide quantum dots (PANI/Ag (AMPSA)/GO QDs) have been synthesized by in situ chemical oxidative polymerization of aniline in the presence of Ag (AMPSA) NPs and GO QDs. Ag (AMPSA) NPs and GO QDs were prepared by AgNO3 chemical reduction and glucose carbonization methods, respectively. The prepared materials were characterized using UV-visible, Fourier transform infrared (FTIR), photoluminescence and Raman spectroscopies, X-Ray diffractometer (XRD) and high- resolution transmission electron microscopy (HRTEM). HRTEM micrographs confirmed the preparation of GO QDs with an average size of 15 nm and Ag (AMPSA) NPs with an average size of 20 nm. PANI/Ag (AMPSA)/GO QDs NC showed high and stable emission peak at 348 nm. This PANI/Ag (AMPSA)/GO QDs NC can emerge as a new class of fluorescence materials that could be suitable for practical sensing applications.

show abstract

“…Here, the FT-IR spectrum of the film deposited using the newly designed reactor (red line, Figure 8 ) clearly exhibits the characteristic peaks of the PANI polymer structure at 1601, 1501, 1313, 1250, and 763 cm −1 . In detail, the peaks at 1501 and 1601 cm −1 are attributed to the benzenoid and quinoid ring stretching vibrations, respectively; the peak at 763 cm −1 is ascribed to the C–H out-of-plane deformation in the aromatic ring, and the bands at 1250 and 1313 cm −1 are ascribed to the C–N stretching vibration [ 32 , 33 , 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Transparent Polyaniline Thin Film Synthesized Using a Low-Voltage-Driven Atmospheric Pressure Plasma Reactor

et al. 2021

View full text Add to dashboard Cite

The use of low-voltage-driven plasma in atmospheric pressure (AP) plasma polymerization is considered as a simple approach to reducing the reactivity of the monomer fragments in order to prevent excessive cross-linking, which would have a negative effect on the structural properties of the polymerized thin films. In this study, AP-plasma polymerization can be processed at low voltage by an AP-plasma reactor with a wire electrode configuration. A bare tungsten wire is used as a powered electrode to initiate discharge in the plasma area (defined as the area between the wide glass tube and the substrate stand), thus allowing plasma polymerization to proceed at a lower voltage compared to other AP-plasma reactors with dielectric barriers. Thus, transparent polyaniline (PANI) films are successfully synthesized. The surface morphology, roughness, and film thickness of the PANI films are characterized by field emission scanning electron microscopy and atomic force microscopy. Thus, the surface of the polymerized film is shown to be homogenous, smooth, and flat, with a low surface roughness of 1 nm. In addition, the structure and chemical properties of the PANI films are investigated by Fourier transform infrared spectroscopy, thus revealing an improvement in the degree of polymerization, even though the process was performed at low voltage.

show abstract

Fabrication and evaluation of evanescent wave absorption based polyaniline-cladding modified fiber optic urea biosensor

Cited by 32 publications

References 34 publications

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Highly Luminescent Ternary Nanocomposite of Polyaniline, Silver Nanoparticles and Graphene Oxide Quantum Dots

Transparent Polyaniline Thin Film Synthesized Using a Low-Voltage-Driven Atmospheric Pressure Plasma Reactor

Contact Info

Product

Resources

About