Fabrication and Evaluation of Multilayer Nanofiber-Hydrogel Meshes with a Controlled Release Property

Abstract

Controlled release drug delivery systems enable the sustained release of bioactive molecules, and increase bioavailability over an extended length of time. Biocompatible and biodegradable materials such as polycaprolactone (PCL) nanofibers and alginate hydrogel play a significant role in designing controlled release systems. Prolonged release of bioactive molecules is observed when these polymer materials are used as matrices independently. However, there has not been a report in the literature that shows how different molecules are released at various rates over time. The goal of this study is to demonstrate a novel drug delivery system that has a property of releasing designated drugs at various rates over a defined length of time. We fabricated multilayer nanofiber-hydrogel meshes using electrospun PCL nanofiber and alginate hydrogel, and evaluated their controlled release properties. The multilayer meshes are composed of sandwiched layers of alternating PCL nanofibers and alginate hydrogel. Adenosine triphosphate (ATP), encapsulated in the designated hydrogel layers, is used as a mock drug for the release study. The exposed top layer of the meshes demonstrates a dramatically higher burst release and shorter release time compared to the deeper layers. Such properties of the different layers within the meshes can be employed to achieve the release of multiple drugs at different rates over a specified length of time.

A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration

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Light Processable Methacrylated Carbon Dot-Hydroxyethyl Cellulose Resins with Potential Applications from Dye Adsorption to Antibacterial Gels and Wet Wipes

“…Information on control synthesis of MHEC+3CD composites; preparation of methacrylated CD (MCD); FTIR spectra of start compounds; different products and results of control reactions including CD, MAA, HEC, MCD, HEC-3CD, MHEC-3CD, and MHEC+3CD; 1 H NMR spectra of CD, HEC-3CD, and MHEC+3CD; evaluation of shear thinning behavior with the help of power law model including tabulated K, n, and R 2 values; SEM micrographs of HEC and MHEC, CD, and CA electrospun mat; and DTG thermographs of degraded gels (XMHEC-1CD and XMHEC-3CD) after 30 The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.…”

Wet-Spun Biofiber for Torsional Artificial Muscles

“…When a return spring is used, the torsional stiffnesses of both the actuating fibre and the return spring become important. When a hydrogel fibre is swollen from it's dry to wet condition, the modulus decreases significantly 45 which also denotes the decrease of torsional stiffness.…”