Fabrication and fluidic characterization of silicon micropillar array electrospray ionization chip

Sainiemi, Lauri; Nissilä, Teemu; Jokinen, Ville; Sikanen, Tiina; Kotiaho, Tapio; Kostiainen, Risto; Ketola, Raimo A.; Franssila, Sami

doi:10.1016/j.snb.2007.09.077

Cited by 47 publications

(35 citation statements)

References 19 publications

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“…2b. In principle, the capillary pressure only requires a positive value in order to propel liquids through the channels (Sainiemi et al 2008). To avoid the negative capillary pressure, it was necessary to enclose the open microchannels since the contact angle of the wall with air is 180…”

Section: Resultsmentioning

confidence: 99%

Development of a microfluidic design for an automatic lab-on-chip operation

Puttaraksa

Whitlow

Napari

et al. 2016

Microfluid Nanofluid

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Simple and easy to use are the keys for developing lab-on-chip technology. Here, a new microfluidic circuit has been designed for an automatic lab-onchip operation (ALOCO) device. This chip used capillary forces for controlled and precise manipulation of liquids, which were loaded in sequence from different flowing directions towards the analysis area. Using the ALOCO design, a non-expert user is able to operate the chip by pipetting liquids into suitable inlet reservoirs. To test this design, microfluidic devices were fabricated using the programmable proximity aperture lithography (PPAL) technique. The operation of the ALOCO chip was characterized from the flow of red-, blue-and un-dyed deionized (DI) water. Experimental result indicated that red water, which filled first the analysis area, was substituted entirely with blue water. Controlled sequential flows of these water in the ALOCO device are demonstrated in this paper.

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Section: Resultsmentioning

confidence: 99%

Development of a microfluidic design for an automatic lab-on-chip operation

Puttaraksa

Whitlow

Napari

et al. 2016

Microfluid Nanofluid

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“…b: The shape of an ESI tip made of SU-8 controlled by front-side wafer processing only (Arscott et al, 2004b). Reprinted with permission from (a) Sainiemi et al (2008) and (b) Arscott et al (2004b). Copyrights 2008 and2004 Elsevier B.V. batch processes with multiple wafers so that low rate can be compensated by a large number of wafers.…”

Section: Etchingmentioning

confidence: 99%

Microchip technology in mass spectrometry

Sikanen

Franssila

Kauppila

et al. 2009

Mass Spectrom. Rev.

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Microfabrication of analytical devices is currently of growing interest and many microfabricated instruments have also entered the field of mass spectrometry (MS). Various (atmospheric pressure) ion sources as well as mass analyzers have been developed exploiting microfabrication techniques. The most common approach thus far has been the miniaturization of the electrospray ion source and its integration with various separation and sampling units. Other ionization techniques, mainly atmospheric pressure chemical ionization and photoionization, have also been subject to miniaturization, though they have not attracted as much attention. Likewise, all common types of mass analyzers have been realized by microfabrication and, in most cases, successfully applied to MS analysis in conjunction with on-chip ionization. This review summarizes the latest achievements in the field of microfabricated ion sources and mass analyzers. Representative applications are reviewed focusing on the development of fully microfabricated systems where ion sources or analyzers are integrated with microfluidic separation devices or microfabricated pums and detectors, respectively. Also the main microfabrication methods, with their possibilities and constraints, are briefly discussed together with the most commonly used materials.

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“…With rapid development in QCR miniaturization, the characteristic scale of surface structures may no longer be very small compared to the thickness of the corresponding QCR. Specially, surface micro-or nano-scale beam arrays have been getting more and more attention due to their great potentials in applications, such as reversible dry adhesives mimicking gecko foot-hair [1,2], superhydrophobic and superoleophobic surfaces [3], tunable wetting [4], micro sensors and actuators [5,6], high-efficiency solar cells and microfluidic devices [7], micro-needles for drug-delivery [1,8] and biosensors, etc. Because these surface micro-beams are with definite structure configurations, effect of the intrinsic properties of additional substance-units on QCR's dynamic behavior gradually becomes evident with increasing ratio of characteristic length of surface loadings to QCR thickness.…”

Section: Introductionmentioning

confidence: 99%

On modeling of a thickness‐shear vibrating quartz crystal plate attached with micro‐beams immersed in liquid with considering couple stress effects

Xie

Chen

et al. 2016

Z Angew Math Mech

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A coupling model for a compound quartz crystal resonator (QCR) system, consisting of a QCR under the thickness-shear mode (TSM) vibrations and surface micro-beam arrays immersed in liquid, is developed using the modified couple stress theory and the Hamilton's variational principle. Couple stresses are included in both governing equations of micro-beams and the quartz crystal plate. Incorporating the boundary conditions, a set of homogeneous equations is numerically solved to get the frequency shift caused by micro-beams for different material parameters, such as Young's modulus and material characteristic length. The normalized beam deflections are plotted and discussed. Influence of couple stresses of both micro-beams and QCR together with their interaction on frequency shift is discussed in detail. The obtained results are useful in measuring geometrical and physical properties of micro-beams using plate-like acoustic wave sensors.

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Fabrication and fluidic characterization of silicon micropillar array electrospray ionization chip

Cited by 47 publications

References 19 publications

Development of a microfluidic design for an automatic lab-on-chip operation

Development of a microfluidic design for an automatic lab-on-chip operation

Microchip technology in mass spectrometry

On modeling of a thickness‐shear vibrating quartz crystal plate attached with micro‐beams immersed in liquid with considering couple stress effects

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