Fabrication and functionalization of biocompatible carboxymethyl chitosan/gelatin membranes<i>via</i>anodic electrophoretic deposition

Wang, Fushi; Qiao, Weiwei; Guo, Weiting; Li, Zhiwen; Cai, Xinjie

doi:10.1039/d1ra09231f

Cited by 4 publications

(3 citation statements)

References 50 publications

(51 reference statements)

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“…The results validated that free neutral surfaces (-CH 3 and -OH) led to greater chondrogenic induction extent but less protein adsorption, cell spreading, and adhesion than charged surfaces (-NH 2 and -COOH) [182]. Negatively charged carboxymethyl chitosan-gelatin (CMCG) composite membranes fabricated via anodic electrophoretic deposition (AED) have demonstrated their ability to transport drugs or other medical agents containing negative charges, which suggested that CMCG membranes could act as a strong candidate for surface functionalised biomaterials with negative charges [183]. The ε-poly-L-lysine (EPL) and phenylboronic acid (PBA)-modified gelatin methacrylamide hydrogels (GelMA-EPL and GelMA-EPL/B) synthesised via Michael addition reaction exhibited positive surface charges, significantly promoting adsorption of negatively charged PGs and secreted PGs in the solution and hence providing a good 3D microenvironment for cartilage repair with improved biocompatibility [184].…”

Section: Surface Chargementioning

confidence: 99%

“…The hydrophobic surface modified with -NH 2 and -CH 3 suppressed the MDA-MB-231 cell adhesion and proliferation, inducing cell apoptosis, and mitochondria-mediated apoptosis by suppressing the phosphatase and TENsin homolog deleted on chromosome 10 (PTEN)/phosphoinositide 3-kinase (PI3K)/Ak strain transforming (AKT) pathway. Negatively charged CMCG composite membranes on titanium (Ti) substrates were produced via the AED-inhibited cell apoptosis of human BMSCs [183]. The presence of gelatin provided some degree of hydrophobic nature for the composite.…”

Section: Surface Wettabilitymentioning

confidence: 99%

“…PCL 3D printed scaffolds fabricated through surface aminolysis and layer-by-layer techniques accelerated the vascular pattern formation of human umbilical ECs and boosted the mineralised matrix production and the expression of osteogenesis-related genes during osteogenic differentiation of MSCs in in vitro studies [230]. CMCG composite membranes on Ti substrates stimulated cell proliferation and adhesion of BMSCs, and showed good biocompatibility for in vitro studies [183].…”

Section: Biocompatibilitymentioning

confidence: 99%

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Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials

Nitti,

Narayanan,

Pellegrino

et al. 2023

Bioengineering

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The advancement achieved in Tissue Engineering is based on a careful and in-depth study of cell–tissue interactions. The choice of a specific biomaterial in Tissue Engineering is fundamental, as it represents an interface for adherent cells in the creation of a microenvironment suitable for cell growth and differentiation. The knowledge of the biochemical and biophysical properties of the extracellular matrix is a useful tool for the optimization of polymeric scaffolds. This review aims to analyse the chemical, physical, and biological parameters on which are possible to act in Tissue Engineering for the optimization of polymeric scaffolds and the most recent progress presented in this field, including the novelty in the modification of the scaffolds’ bulk and surface from a chemical and physical point of view to improve cell–biomaterial interaction. Moreover, we underline how understanding the impact of scaffolds on cell fate is of paramount importance for the successful advancement of Tissue Engineering. Finally, we conclude by reporting the future perspectives in this field in continuous development.

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Section: Surface Chargementioning

confidence: 99%

Section: Surface Wettabilitymentioning

confidence: 99%