Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles

Rahman, Md. Abdur; Ochiai, Bungo

doi:10.1007/s00542-017-3318-8

Cited by 12 publications

(18 citation statements)

References 58 publications

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“…The XRD profile (figure 4(a)) of bare IONPs showed characteristic six diffraction peaks at 2θ values of 30.08°, 35.45°, 43.50°, 53.54°, 57.11°and 62.78°, which are assignable to (220), (311), (400), (422), (511), and (440) Brava is planes of fcc Fe 3 O 4 , respectively (JCPDS card no. 19-0629) [32]. These reflections also appeared in the XRD patterns of PAA functionalized IONPs (figures 4(b) and (c)) and no any additional sharp peak of other iron compounds is observable, which imply the phase purity, in situ formation of Fe 3 O 4 and its crystal structure was not hindered by PAA functionalization.…”

Section: Resultsmentioning

confidence: 77%

“…In the spectrum of bare IONPs, the characteristic stretching vibration bands appeared at 424 and 578 cm −1 , which are assignable to the Fe-O bond vibrations.These bands were shifted to 429 and 583 cm −1 in the FTIR spectra of PAA functionalized IONPs due to the polyelectrolytic interaction of the carboxylate moieties with the surface of IONPs. A stretching broad band occurred in the region of 3200-3500 cm −1 and a bending band was also observed at 1625 cm −1 indicating to -O-H moieties of the adsorbed and hydrogen bonded water molecules onto the surface of IONPs [32,34,35]. In the spectrum of pure PAA, a strong band at 1718 cm −1 assignable to the carbonyl group stretch of the PAA and the band at 1410-1450 cm −1 are corresponded to the stretch of C-O and the deformation vibration of OH, and this band was shifted to 1400 cm −1 in the spectra of PAA functionalized IONPs [36].…”

Section: Resultsmentioning

confidence: 96%

“…As a one-pot process, Yang et al and Xiwen et al had prepared PAA-coated Fe 3 O 4 nanoparticles by using solvothermal processes [30,31]. In spite of the single process, these methods are tedious due to the requirements of organic solvents and vigorous reaction conditions, often resulting in surface contaminated particles with organic co-solvent and relatively weaker magnetic property and also offering large-sized particles that are unsuitable for bio-related applications [32]. On the other hand, the synthesis and surface functionalization of IONPs via one-pot free radical solution polymerization of acrylic acid (AA) and one-pot in situ co-precipitation method is facile, economical and scalable.…”

Section: Introductionmentioning

confidence: 99%

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A facile one-pot synthesis of poly(acrylic acid)-functionalized magnetic iron oxide nanoparticles for suppressing reactive oxygen species generation and adsorption of biocatalyst

Nahar

Rahman

Hossain

et al. 2019

Mater. Res. Express

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Functionalized iron oxide nanoparticles (IONPs) have unique physical and chemical properties, which make them potential candidates for biomedical applications. In this study, a facile one-pot method is reported for the preparation of poly(acrylic acid) (PAA) functionalized IONPsthrough in situ free radical solution polymerization of AA and subsequent coprecipitation of Fe 3+ and Fe 2+ ions. The FTIR spectroscopic and TGA results indicated the successful formation and surface functionalization of IONPs with PAA. Electron micrographs showed that the prepared particles were of nano-sized and their shape is dependent on the concentration of PAA. pH-dependent variation of average hydrodynamic diameter confirmed the pH-responsivity of PAA-functionalized IONPs. Magnetic measurement suggested that the PAA functionalized IONPs were strongly paramagnetic (53.0 emug −1 ). Fenton-like catalytic generation is carried out to measure toxicity associated with the nanoparticles. The suppression ability for reactive oxygen species (ROS) generation associated with PAA-functionalized IONPs was studied via methylene blue degradation assay to address their toxicity profile. PAA-functionalized IONPs exhibited better suppression ability than that of the bare IONPs. The adsorption behavior of trypsin was also studied at different pH levels and a maximum adsorption is occurred on PAA-functionalized IONPs at pH 5.0. Catalytic behavior study confirmed higher activity of trypsin immobilized on PAA-functionalized IONPs than that of the reference IONPs. Therefore, the functionalized IONPs can be of high interest for magnetically recyclable biocatalyst carrier.

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Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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A facile one-pot synthesis of poly(acrylic acid)-functionalized magnetic iron oxide nanoparticles for suppressing reactive oxygen species generation and adsorption of biocatalyst

Nahar

Rahman

Hossain

et al. 2019

Mater. Res. Express

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“…53 Two medium-intense bands were also observed at 1555 and 1634 cm –1 , which are assignable to the absorption of amides I and II and C=C, respectively. 54 A very broad signal observed in the region of 3330–3440 cm –1 is assignable to the stretching vibration bands of O–H and N–H groups, respectively. These results indicate that the surface of Fe 3 O 4 was efficiently coated with NICS-EGDE.…”

Section: Results and Discussionmentioning

confidence: 97%

pH-Responsive Charge-Conversional and Hemolytic Activities of Magnetic Nanocomposite Particles for Cell-Targeted Hyperthermia

et al. 2018

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Magnetic nanocomposite particle (MNP)-induced hyperthermia therapy has been restricted by inefficient cellular targeting. pH-responsive charge-conversional MNPs can enhance selective cellular uptake in acidic cells like tumors by sensing extracellular acidity based on their charge alteration. We have synthesized new, pH-induced charge-conversional, superparamagnetic, and single-cored Fe3O4 nanocomposite particles coated by N-itaconylated chitosan (NICS) cross-linked with ethylene glycol diglycidyl ether (EGDE) (Fe3O4-NICS-EGDE) using a simple, one-step chemical coprecipitation–coating process. The surface of the Fe3O4-NICS-EGDE nanocomposite particles was modified with ethanolamine (EA) via aza-Michael addition to enhance their buffering capacity, aqueous stability, and pH sensitivity. The designed Fe3O4-NICS-EGDE-EA nanocomposite particles showed pH-dependent charge-conversional properties, colloidal stability, and excellent hemocompatibility in physiological media. By contrast, the charge-conversional properties enabled microwave-induced hemolysis only under weakly acidic conditions. Therefore, the composite particles are highly feasible for magnetically induced and targeted cellular thermotherapeutic applications.

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“…On the other hand, other studies show the hemocompatibility of chitosan in experiments with hemolytic activity, platelet aggregation, coagulation, and cytokine induction [8]. Many researchers have shown the improved and enhanced hemocompatibility of chitosan with additions, such as alginate [9] or polyethersulfone [10], or by chitosan modification: sulfonation [11] or carboxylation [12].…”

Section: Introductionmentioning

confidence: 99%

Hemocompatible Chitin-Chitosan Composite Fibers

et al. 2020

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Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown that low CNF concentration (about 0.5%) leads to an increase in fiber tensile strength due to the additional orientation of chitosan macromolecules. At the same time, with an increase in the content of CNF, the stability of the mechanical properties of composite fibers in a humid medium increases. All chitosan fibers, except 0.5% CNF, showed good hemocompatibility, even on prolonged contact with human blood. The addition of chitin nanofibers leads to decrease in hemoglobin molecules sorption due to the decline in optical density at wavelengths of 414 nm and 540 nm. Nevertheless, the hemolysis of fibers was comparable or even lesser that carbon hemosorbent, which is actively used in clinical practice.

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Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles

Cited by 12 publications

References 58 publications

A facile one-pot synthesis of poly(acrylic acid)-functionalized magnetic iron oxide nanoparticles for suppressing reactive oxygen species generation and adsorption of biocatalyst

A facile one-pot synthesis of poly(acrylic acid)-functionalized magnetic iron oxide nanoparticles for suppressing reactive oxygen species generation and adsorption of biocatalyst

pH-Responsive Charge-Conversional and Hemolytic Activities of Magnetic Nanocomposite Particles for Cell-Targeted Hyperthermia

Hemocompatible Chitin-Chitosan Composite Fibers

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