Fabrication and improvement of PCL/alginate/PAAm scaffold via selective laser sintering for tissue engineering

Wu, Jie; Yang, Runhuai; Zheng, Junrong; Pan, Linxin; Li, Xiaoying

doi:10.1049/mnl.2018.5806

Cited by 18 publications

(9 citation statements)

References 24 publications

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“…[60] Wu et al prepared PCL scaffold using SLS, and found that the scaffold exhibited great porosity, mechanical properties and biocompatibility. [208] By using this method, the micropore system including the size, shape, distribution, spatial orientation, and connectivity in bone scaffold can be accurately controlled by matching the laser spot diameter and scanning spacing, thus meeting the spatial structure requirements of bone regeneration. Meanwhile, any complex shape and individual characteristics of bone scaffold can be quickly prepared according to the different shapes of bone defect.…”

Section: Individual Shapementioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Section: Individual Shapementioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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“…Moreover, this method can use ultra-high molecular weights of polyethylene. Unfortunately, in this process, an additional procedure is required to remove the injected powder, which, in addition to its high operating temperature, is the main disadvantage of SLS [ 5 , 141 ]. In addition to RP, relevant methods include stereolithography (SLA) [ 142 , 143 , 144 ] and fused deposition modeling (FDM) for creating an object through the controlled deposition of molten material [ 5 , 145 , 146 ].…”

Section: Scaffold For Articular Cartilage Repair: Requirements Mamentioning

confidence: 99%

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

2020

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Cartilage tissue is under extensive investigation in tissue engineering and regenerative medicine studies because of its limited regenerative potential. Currently, many scaffolds are undergoing scientific and clinical research. A key for appropriate scaffolding is the assurance of a temporary cellular environment that allows the cells to function as in native tissue. These scaffolds should meet the relevant requirements, including appropriate architecture and physicochemical and biological properties. This is necessary for proper cell growth, which is associated with the adequate regeneration of cartilage. This paper presents a review of the development of scaffolds from synthetic polymers and hybrid materials employed for the engineering of cartilage tissue and regenerative medicine. Initially, general information on articular cartilage and an overview of the clinical strategies for the treatment of cartilage defects are presented. Then, the requirements for scaffolds in regenerative medicine, materials intended for membranes, and methods for obtaining them are briefly described. We also describe the hybrid materials that combine the advantages of both synthetic and natural polymers, which provide better properties for the scaffold. The last part of the article is focused on scaffolds in cartilage tissue engineering that have been confirmed by undergoing preclinical and clinical tests.

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“…Alginate is a naturally occurring anionic polymer typically obtained from brown seaweed, which is used as a core, giving stability in MCs due to its biocompatibility, low toxicity, low cost, and fast sol–gel transition in contact with divalent cations. However, this polymer is unable to specifically interact with mammalian cells due to the presence of negative charges and its deficiency of integrin domains [71–73]. Thus, conventional methods to overcome this disadvantage include blending with natural proteins such as silk proteins.…”

Section: Silk Fibroin‐based Mcsmentioning

confidence: 99%

“…Although the use of bioreactors to perform cell seeding on MCs is a promising way to mimic and simulate the biological environment in order to obtain 3D constructs, studies of fibroin‐based MCs with dynamic cell culture are still scarce [60–74].…”

Section: Future Perspectivesmentioning

confidence: 99%