Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Abstract

Background: Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro. Methods: BBF-loaded PLLA nanoparticles were prepared using the emulsion solventevaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium. Results: The BBF-loaded PLLA nanoparticles had a small particle size (408 ± 14 nm), a low polydispersity index (0.140 ± 0.008), a high encapsulation efficiency (72.44% ± 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours. Conclusion:The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.

Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

“…Furanones were also loaded into microparticles [26] and nanoparticles [27]. Specifically, Cheng et al [27] used the halogenated 4-bromo-5-(bromomethylene)-2(5H)-furanone in combination with biodegradable poly-DL-lactic acid nanoparticles to fabricate a novel antibacterial coating for titanium (Ti) implants. Ti material may also be used for tympanostomy tubes.…”

Propolis extract as a green bacterial corrosion inhibitor on three types of metals

“…Interestingly, the presence of functional groups in propanoic acid such as hydroxyl groups, ethylene oxide, carbonyl, double bonds, benzene rings, oxygen atoms, nitrogen atoms in addition to the hydrophobic chain of the surfactant is responsible for increasing its adsorption ability on the steel surface (Abd-Elaal et al 2018). Furanon compounds have the potential to inhibit microbial corrosion associated with Gram-positive bacteria (Srinivasan et al 2021;Wu et al 2012). Based on previous research, it was found that the addition of a concentration of 40 mg/ml furanone was able to inhibit the growth of Desulfotomaculum orientis (a microbe that causes corrosion) by 96% (Ren et al 2001).…”

The prospects of antimicrobial coated medical implants

“…This period is considered long enough to prevent implant-associated infections during the initial stages of device implantation. 97–99…”

“…This period is considered long enough to prevent implant-associated infections during the initial stages of device implantation. [97][98][99] Nitric oxide-releasing coatings: Nitric oxide is wellrecognized for its activity in the inhibition of platelets adhesion and activation therefore nitric oxide coatings on silicone, polyurethane and polymethacrylate can be potentially used as thrombo-resistant coatings on many biomedical devices including in vivo sensors, catheters, stents, arteriovenous grafts, and extracorporeal circuits. Moreover, the anti-biofilm activity of nitric oxide has been proved and therefore may be used for the development of antimicrobial/antithrombotic CVCs because of the double effect of nitric oxide.…”