Fabrication and optical manipulation of micro-robots for biomedical applications

Zhang, Dandan; Ren, Yunxiao; Barbot, Antoine; Seichepine, Florent; Lo, Benny; Ma, Zhuo‐Chen; Yang, Guang‐Zhong

doi:10.1016/j.matt.2022.07.003

Cited by 13 publications

(3 citation statements)

References 146 publications

(192 reference statements)

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“…Microrobots can be actuated by magnetic, acoustic, and optical fields [3,[8][9][10]. Magnetic fields have emerged as a critical element in the control and operation of microrobots, especially in the realm of in vivo medical applications.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Microrobots for In Vivo Cargo Delivery: A Review

Lin,

Cong,

Zhang

2024

Micromachines

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Magnetic microrobots, with their small size and agile maneuverability, are well-suited for navigating the intricate and confined spaces within the human body. In vivo cargo delivery within the context of microrobotics involves the use of microrobots to transport and administer drugs and cells directly to the targeted regions within a living organism. The principal aim is to enhance the precision, efficiency, and safety of therapeutic interventions. Despite their potential, there is a shortage of comprehensive reviews on the use of magnetic microrobots for in vivo cargo delivery from both research and engineering perspectives, particularly those published after 2019. This review addresses this gap by disentangling recent advancements in magnetic microrobots for in vivo cargo delivery. It summarizes their actuation platforms, structural designs, cargo loading and release methods, tracking methods, navigation algorithms, and degradation and retrieval methods. Finally, it highlights potential research directions. This review aims to provide a comprehensive summary of the current landscape of magnetic microrobot technologies for in vivo cargo delivery. It highlights their present implementation methods, capabilities, and prospective research directions. The review also examines significant innovations and inherent challenges in biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Magnetic Microrobots for In Vivo Cargo Delivery: A Review

Lin,

Cong,

Zhang

2024

Micromachines

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“…[64,66,67] In a more general sense, microrobots also include simple nano/microparticles functionalized with stimuli-responsive materials, which have seen a large variety of environmental and biomedical applications in recent years. [59,60,[80][81][82] They are proposed and demonstrated to capture, remove or degrade microplastic particles and synthetic fibers, among many other solid wastes in water bodies. [83][84][85][86][87][88][89][90] Microrobots, controlled and navigated by external operators through magnetic, acoustic, light, or chemical fields, can perform targeted drug delivery, [91][92][93] tissue regeneration, [94] disease diagnosis, [95,96] cancer therapy, [97][98][99] and biofilm removal.…”

Section: Introductionmentioning

confidence: 99%

Colloidal State Machines as Smart Tracers for Chemical Reactor Analysis

Zhang

Yang

et al. 2023

Advanced Intelligent Systems

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A widely utilized tool in reactor analysis is passive tracers that report the residence time distribution, allowing estimation of the conversion and other properties of the system. Recently, advances in microrobotics have introduced powered and functional entities with sizes comparable to some traditional tracers. This has motivated the concept of Smart Tracers that could record the local chemical concentrations, temperature, or other conditions as they progress through reactors. Herein, the design constraints and advantages of Smart Tracers by simulating their operation in a laminar flow reactor model conducting chemical reactions of various orders are analyzed. It is noted that far fewer particles are necessary to completely map even the most complex concentration gradients compared with their conventional counterparts. Design criteria explored herein include sampling frequency, memory storage capacity, and ensemble number necessary to achieve the required accuracy to inform a reactor model. Cases of severe particle diffusion and sensor noise appear to bind the functional upper limit of such probes and require consideration for future design. The results of the study provide a starting framework for applying the new technology of microrobotics to the broad and impactful set of problems classified as chemical reactor analysis.

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“…Existing systems for biological object manipulation are frequently manually controlled, and many of these systems are tested not with biological specimens, but with polymer or metal micro-objects [4]. User participation is currently required to determine the position of the object and the distance to the object being manipulated.…”

Section: Introductionmentioning

confidence: 99%

A Vision-Based Micro-Manipulation System

Vismanis,

Arents,

Subačiūtė-Žemaitienė

et al. 2023

Applied Sciences

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This research article outlines the design and methodology employed in the development of a vision-based micro-manipulation system, emphasizing its constituent components. While the system is initially tailored for applications involving living cells, its adaptability to other objects is highlighted. The integral components include an image enhancement module for data preparation, an object detector trained on the pre-processed data, and a precision micro-manipulator for actuating towards detected objects. Each component undergoes rigorous precision testing, revealing that the proposed image enhancement, when combined with the object detector, outperforms conventional methods. Additionally, the micro-manipulator shows excellent results for working with living cells the size of yeast. In the end, the components are also tested in a combined system as a proof-of-concept.

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Fabrication and optical manipulation of micro-robots for biomedical applications

Cited by 13 publications

References 146 publications

Magnetic Microrobots for In Vivo Cargo Delivery: A Review

Magnetic Microrobots for In Vivo Cargo Delivery: A Review

Colloidal State Machines as Smart Tracers for Chemical Reactor Analysis

A Vision-Based Micro-Manipulation System

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