Fabrication and optimization of raloxifene loaded spanlastics vesicle for transdermal delivery

Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers: Optimization, In Vitro, Ex Vivo, and In Vivo Studies

“…In this study, results can be inferred as increasing CHO molar ratio might decrease the aggregation of QAS molecules into micelles by increasing their hydrophobic interaction. The sonication time (X 3 ) had a negative effect on the quatsomes size due to the breaking of the vesicles [ 46 ].…”

Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation

“…The rats' skin was cross-sectioned mechanically using a specially designed cross-section device ( van Kuijk-Meuwissen et al, 1998 ), and mounted homogeneously onto the Franz diffusion cell for 6 h. The skin is then scraped, and a slide is generated. The slide after that is tested with a Confocal Microscope (Leica TCS Spectral CLSM 710, UK) using argon laser beam (excitation wavelength: 488 nm, emission wavelength: 590 nm) ( Ansari et al, 2022 ).…”

“…Spanlastics, nanovesicles consisting of a nonionic surfactant such as Span as bilayer forming agents and an edge activator (EA) that enhances the elasticity and flexibility of the bilayer membrane ( Ansari et al, 2022 ). Spanlastics have recently surfaced as a potential solution for topical drug delivering, addressing the inherent challenges posed by the stratum corneum.…”

Leciplex produced on a pilot scale: production and in-vitro characterization

“…The PS of LPX batches was not significantly affected by batch volumes (p=0.083); the PS of all batches prepared with varied volumes but with the same mixing speed and time was not significantly different, meaning that the LPX could be prepared with varying volumes without altering its PS. On the contrary, increasing the mixing speed significantly reduced the PS of LPX batches (p=0.005), as increasing the mixing speed breaks the vesicles into smaller ones [12]. The mixing time did not significantly affect the PS (p= 0.062); however, upon studying the PS in different LPX batches, it was found that upon increasing the mixing time from 10 to 15 min, the PS was slightly reduced and on further increase, the mixing time to 20 min the PS was increased, indicating a quadratic model.…”