Fabrication, Characterization and Application of Sugar Microneedles for Transdermal Drug Delivery

Nguyen, Hiep X.; Banga, Ajay K.

doi:10.4155/tde-2016-0096

Cited by 44 publications

(28 citation statements)

References 40 publications

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“…Skin conductivity indicates the skin integrity. Particularly, a sudden decrease in the skin electrical resistance denoted the disruption of the skin barrier [ 11 ]. After skin resistance measurement, 5 sheets of Kimwipes were gently dabbed on the skin surface to remove PBS solution before the transepidermal water loss value (TEWL) was measured.…”

Section: Methodsmentioning

confidence: 99%

“…Treated skin samples were mounted on vertical Franz diffusion cells for the TEWL measurement ( n = 4). The TEWL values depicted the effects of the physical treatments on the skin intactness, with an increase suggesting compromised skin [ 10 , 11 ]. We also measured the skin temperature before and after the physical treatments and reported the results as the increase in the skin temperature (%, n = 4).…”

Section: Methodsmentioning

confidence: 99%

“…Drug delivery through the skin could be influenced by several factors, including skin integrity, the properties of the compound, and the composition of the formulation [ 8 ]. Transdermal drug delivery could be enhanced by optimizing the drug formulations or disrupting the integrity of the skin barrier using chemical penetration enhancers or physical methods, such as microneedles, laser, sonophoresis, and iontophoresis (ITP) [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Electrically and Ultrasonically Enhanced Transdermal Delivery of Methotrexate

Nguyen

Banga

2018

Pharmaceutics

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In this study, we used sonophoresis and iontophoresis to enhance the in vitro delivery of methotrexate through human cadaver skin. Iontophoresis was applied for 60 min at a 0.4 mA/sq·cm current density, while low-frequency sonophoresis was applied at a 20 kHz frequency (2 min application, and 6.9 W/sq·cm intensity). The treated skin was characterized by dye binding, transepidermal water loss, skin electrical resistance, and skin temperature measurement. Both sonophoresis and iontophoresis resulted in a significant reduction in skin electrical resistance as well as a marked increase in transepidermal water loss value (p < 0.05). Furthermore, the ultrasonic waves resulted in a significant increase in skin temperature (p < 0.05). In permeation studies, the use of iontophoresis led to a significantly higher drug permeability than the untreated group (n = 4, p < 0.05). The skin became markedly more permeable to methotrexate after the treatment by sonophoresis than by iontophoresis (p < 0.01). A synergistic effect for the combined application of sonophoresis and iontophoresis was also observed. Drug distribution in the skin layers revealed a significantly higher level of methotrexate in the sonicated skin than that in iontophoresis and untreated groups. Iontophoresis and low-frequency sonophoresis were found to enhance the transdermal and intradermal delivery of methotrexate in vitro.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrically and Ultrasonically Enhanced Transdermal Delivery of Methotrexate

Nguyen

Banga

2018

Pharmaceutics

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“…Microneedles offer multiple superior advantages such as enhancement of drug delivery, patient compliance and adherence [14][15][16]; minimization of sharps handling and drug waste; elimination of vaccine reconstitution prior to administration; and avoidance of needle-related risks (pain, infection, and needle-stick injuries) [2,17,18]. The simple application of microneedles could facilitate the vaccinations with minimally trained health caregivers and potential self-administration by patients [2,8,13].…”

Section: Editorialmentioning

confidence: 99%

Economic Evaluation of Microneedles for Vaccinations

Nguyen¹,

Vu²,

Nguyen³

2018

J Pharmacovigil

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“…The drug delivery can be enhanced by optimizing the drug formulations or disrupting the skin barrier function using either chemical penetration enhancers or physical enhancement technologies including microneedles, laser, sonophoresis, iontophoresis, and thermal energy [6,7]. Microneedles application is a minimally invasive, cost-effective, and patient-compliant technique to significantly enhance the drug delivery into and across skin [8][9][10]. Upon being inserted into the skin, microneedles disrupt the stratum corneum and penetrate the epidermis layer to create interstitial fluid-filled and micronsized channels in skin.…”

mentioning

confidence: 99%