Fabrication, characterization and examination of <i>in vitro</i> of baghdadite nanoparticles for biomedical applications

Arefpour, Ahmadreza; Kasiri‐Asgarani, Masoud; Monshi, Ahmad; Doostmohammadi, Ali; Karbasi, Saeed

doi:10.1088/2053-1591/ab318c

Cited by 12 publications

(13 citation statements)

References 22 publications

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“…in which V solid is the solid volume and V total is the total volume of the scaffold. The porosities of various SiCa and composite scaffolds have been measured using the aforementioned methods: liquid displacement (distilled water), [33,49,50,59,67,68,70,71,74, liquid displacement (ethanol), [121][122][123][124][125] liquid displacement (hexane), [126][127][128][129] liquid displacement (kerosene), [130] mercury intrusion, [131][132][133][134][135] gravimetry [45,65,110,[136][137][138] , μ-CT, [114,116,[139][140][141][142][143][144][145] 1, and SEM [75,84,85,143,[146][147][148][149][150] acc...…”

Section: Imaging Techniquesmentioning

confidence: 99%

“…A polymeric coating can bridge the cracks, [59,118,128] fill out the crack-like defect in the struts, [141] and densify the struts and clog pores in scaffolds. [98,101,121]…”

Section: Correlation Between Pores and Cracksmentioning

confidence: 99%

“…Such polymeric coatings were found to decrease the pore size and increase the compressive strength. [84,94,117,118,120,121,141] For instance, the PCL coating enhanced the compressive strength of a baghdadite scaffold. This is because of the chemical reaction between the silanol group Si─O─H and the hydroxyl group in PCL on the surface of the scaffold, forming a strong bond between the ceramic matrix and the polymer coating.…”

Section: Effect Of Coatingmentioning

confidence: 99%

“…[24] Increasing dip coating time of PCL led to an increase in the compressive strength of a baghdadite scaffold. [121] The number of coating layers also affects the porosity and compressive strength of porous scaffolds. For instance, a silk coating on a Sr-HT-Ga biphasic scaffold decreased the porosity and improved the compressive strength, [150] and increasing the number of coating layers decreased the porosity and pore interconnectivity.…”

Section: Effect Of Coatingmentioning

confidence: 99%

“…Applying a polymer coating on the ceramic scaffold can improve the compressive strength of the scaffold. [196] Hitherto, various polymers such as polycaprolactone fumarate (PCLF), [94,118] polycaprolactone (PCL), [84,118,120,121,141] poly(lactic-co-glycolic acid) (PLGA) [96,98,101] and silk [59,128,150] have been used as coating on SiCa scaffolds. Such polymeric coatings were found to decrease the pore size and increase the compressive strength.…”

Section: Effect Of Coatingmentioning

confidence: 99%

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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Section: Imaging Techniquesmentioning

confidence: 99%

“…A polymeric coating can bridge the cracks, [59,118,128] fill out the crack-like defect in the struts, [141] and densify the struts and clog pores in scaffolds. [98,101,121]…”

Section: Correlation Between Pores and Cracksmentioning

confidence: 99%

Section: Effect Of Coatingmentioning

confidence: 99%

Section: Effect Of Coatingmentioning

confidence: 99%

Section: Effect Of Coatingmentioning

confidence: 99%

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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A comparison between β‐tricalcium phosphate and chitosanpoly‐caprolactone‐based3Dmelt extruded composite scaffolds

et al. 2021

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Melt extrusion 3D printing has become an attractive additive manufacturing technology to construct degradable scaffolds as tissue precursors in order to create clinically relevant medical devices. Towards this end, a commonly used synthetic polyester, poly‐caprolactone (PCL), was used to make scaffolds composed of different biomaterial compositions to increase bioactivity using 3D melt pneumatic extrusion technology. Varying ratios of the natural biopolymer, chitosan, or the bioceramic, β‐tricalcium phosphate (TCP) were blended with PCL to fabricate support scaffolds with three‐dimensional (3D) architecture for human bone‐marrow derived mesenchymal stem cell (hBMSC) growth for potential bone regeneration application. In this study, basic printing requirements as well as biomaterial dynamic mechanical (DMA), elemental, and thermogravimetric (TGA) analysis results demonstrate material homogeneity as well as thermal stability. Scaffold morphology and microarchitecture were assessed using scanning electron microscopy (SEM) alongside in vitro scaffold degradation and biological characterisation. Human BMSC proliferation was assessed using fluorescence imaging, and quantitated via the 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide (MTT) colorimetric assay. These in vitro cell viability studies revealed that the highest chitosan concentration blend of 20% favoured the most hBMSC growth, exhibited the most swelling, and showed minimal degradation after 28 days. The 20% TCP blend had the second highest hBMSC growth, exhibited moderate swelling, and the fastest degradation rate. Overall, this study demonstrates the first direct comparison of a natural biopolymer‐based, that is, chitosan, 3D melt extruded PCL composite with that of a bioceramic‐based, that is, β‐TCP, PCL composite and their effects on hBMSC 3D proliferation. 3D melt extruded PCL‐based composite scaffolds methodology offers a straightforward way to print scaffolds with good shape fidelity, interconnected porosities and enhanced bioactivity; and demonstrates their potential use for regenerative, bone repair applications.

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