Fabrication of 3D printed head phantom using plaster mixed with polylactic acid powder for patient-specific QA in intensity-modulated radiotherapy

Kim, Sung Yeop; Park, Jae Won; Yea, Ji Woon; Oh, Se An

doi:10.1038/s41598-022-22520-6

Cited by 11 publications

(7 citation statements)

References 15 publications

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“…The obtained CT number values allow the entire head phantom to be reasonably manufactured and used in clinical surroundings using a single commercially available resin and a single 3D printing device. Results and findings of the recently published articles [66,67] can spark new investigations in this area of science and can pave the way to directions of future investigations. In the first paper, the authors were able to reproduce a commercial Rando phantom with appropriate HU values for bone and soft tissue [66].…”

Section: Discussionmentioning

confidence: 90%

“…Results and findings of the recently published articles [66,67] can spark new investigations in this area of science and can pave the way to directions of future investigations. In the first paper, the authors were able to reproduce a commercial Rando phantom with appropriate HU values for bone and soft tissue [66]. The obtained 3D-printed head phantom was suitable for use in phantom-based, patent-specific Quality Assurance (QA), which is very important in radiotherapy.…”

Section: Discussionmentioning

confidence: 90%

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Utilisation of 3D Printing in the Manufacturing of an Anthropomorphic Paediatric Head Phantom for the Optimisation of Scanning Parameters in CT

et al. 2023

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Computed tomography (CT) is a diagnostic imaging process that uses ionising radiation to obtain information about the interior anatomic structure of the human body. Considering that the medical use of ionising radiation implies exposing patients to radiation that may lead to unwanted stochastic effects and that those effects are less probable at lower doses, optimising imaging protocols is of great importance. In this paper, we used an assembled 3D-printed infant head phantom and matched its image quality parameters with those obtained for a commercially available adult head phantom using the imaging protocol dedicated for adult patients. In accordance with the results, an optimised scanning protocol was designed which resulted in dose reductions for paediatric patients while keeping image quality at an adequate level.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Utilisation of 3D Printing in the Manufacturing of an Anthropomorphic Paediatric Head Phantom for the Optimisation of Scanning Parameters in CT

et al. 2023

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“…This infill value of PLA is considered to be reasonable for reproducing human soft tissue according to its HU value in comparison to the Rando phantom (Alderson Radiation Therapy Phantom), which is known to be equivalent to the human body in terms of X-ray absorption and scattering. According to a recent study, the mean HU values of the Rando phantom are -22.5 HU for soft tissue; the soft tissue phantom can be printed with a -20 HU value by using an 82% infill value with a high dice similarity coefficient (DSC = 0.9) [ 25 ]. Therefore, in an attempt to replicate the human head attenuation profile more precisely, plaster was used for bone tissue [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Robustness of radiomic features in 123I-ioflupane-dopamine transporter single-photon emission computer tomography scan

Laskov,

Rothbauer,

Malikova

2024

PLoS ONE

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Radiomic features are usually used to predict target variables such as the absence or presence of a disease, treatment response, or time to symptom progression. One of the potential clinical applications is in patients with Parkinson’s disease. Robust radiomic features for this specific imaging method have not yet been identified, which is necessary for proper feature selection. Thus, we are assessing the robustness of radiomic features in dopamine transporter imaging (DaT). For this study, we made an anthropomorphic head phantom with tissue heterogeneity using a personal 3D printer (polylactide 82% infill); the bone was subsequently reproduced with plaster. A surgical cotton ball with radiotracer (123I-ioflupane) was inserted. Scans were performed on the two-detector hybrid camera with acquisition parameters corresponding to international guidelines for DaT single photon emission tomography (SPECT). Reconstruction of SPECT was performed on a clinical workstation with iterative algorithms. Open-source LifeX software was used to extract 134 radiomic features. Statistical analysis was made in RStudio using the intraclass correlation coefficient (ICC) and coefficient of variation (COV). Overall, radiomic features in different reconstruction parameters showed a moderate reproducibility rate (ICC = 0.636, p <0.01). Assessment of ICC and COV within CT attenuation correction (CTAC) and non-attenuation correction (NAC) groups and within particular feature classes showed an excellent reproducibility rate (ICC > 0.9, p < 0.01), except for an intensity-based NAC group, where radiomic features showed a good repeatability rate (ICC = 0.893, p <0.01). By our results, CTAC becomes the main threat to feature stability. However, many radiomic features were sensitive to the selected reconstruction algorithm irrespectively to the attenuation correction. Radiomic features extracted from DaT-SPECT showed moderate to excellent reproducibility rates. These results make them suitable for clinical practice and human studies, but awareness of feature selection should be held, as some radiomic features are more robust than others.

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“…Although various studies addressing patient‐specific printed phantoms have been published, 5,11–14 only few studies have performed detailed comparisons to conventionally produced anthropomorphic phantoms 1,2,15,16 . In the latter studies, computed tomography (CT) values (given in Hounsfield units [HU]) of reference phantoms could be reproduced with sufficient accuracy.…”

Section: Introductionmentioning

confidence: 99%

“…Although various studies addressing patientspecific printed phantoms have been published, 5,[11][12][13][14] only few studies have performed detailed comparisons to conventionally produced anthropomorphic phantoms. 1,2,15,16 In the latter studies, computed tomography (CT) values (given in Hounsfield units [HU]) of reference phantoms could be reproduced with sufficient accuracy. However, the dosimetric characteristics of printed phantoms were verified for radiation therapy only, 2 but not for x-rays in the energy range typically used in diagnostic imaging.…”

Section: Introductionmentioning

confidence: 99%

Reproduction of a conventional anthropomorphic female chest phantom by 3D‐printing: Comparison of image contrasts and absorbed doses in CT

et al. 2023

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BackgroundThe production of individualized anthropomorphic phantoms via three‐dimensional (3D) printing methods offers promising possibilities to assess and optimize radiation exposures for specifically relevant patient groups (i.e., overweighed or pregnant persons) that are not adequately represented by standardized anthropomorphic phantoms. However, the equivalence of printed phantoms must be demonstrated exemplarily with respect to the resulting image contrasts and dose distributions.PurposeTo reproduce a conventionally produced anthropomorphic phantom of a female chest and breasts and to evaluate their equivalence with respect to image contrasts and absorbed doses at the example of a computed tomography (CT) examination of the chest.MethodsIn a first step, the effect of different print settings on the CT values of printed samples was systematically investigated. Subsequently, a transversal slice and breast add‐ons of a conventionally produced female body phantom were reproduced using a multi‐material extrusion‐based printer, considering six different types of tissues (muscle, lung, adipose, and glandular breast tissue, as well as bone and cartilage). CT images of the printed and conventionally produced phantom parts were evaluated with respect to their geometric correspondence, image contrasts, and absorbed doses measured using thermoluminescent dosimeters.ResultsCT values of printed objects are highly sensitive to the selected print settings. The soft tissues of the conventionally produced phantom could be reproduced with a good agreement. Minor differences in CT values were observed for bone and lung tissue, whereas absorbed doses to the relevant tissues were identical within the measurement uncertainties.Conclusion3D‐printed phantoms are with exception of minor contrast differences equivalent to their conventionally manufactured counterparts. When comparing the two production techniques, it is important to note that conventionally manufactured phantoms should not be considered as absolute benchmarks, as they also only approximate the human body in terms of its absorption, and attenuation of x‐rays as well as its geometry.

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Fabrication of 3D printed head phantom using plaster mixed with polylactic acid powder for patient-specific QA in intensity-modulated radiotherapy

Cited by 11 publications

References 15 publications

Utilisation of 3D Printing in the Manufacturing of an Anthropomorphic Paediatric Head Phantom for the Optimisation of Scanning Parameters in CT

Utilisation of 3D Printing in the Manufacturing of an Anthropomorphic Paediatric Head Phantom for the Optimisation of Scanning Parameters in CT

Robustness of radiomic features in 123I-ioflupane-dopamine transporter single-photon emission computer tomography scan

Reproduction of a conventional anthropomorphic female chest phantom by 3D‐printing: Comparison of image contrasts and absorbed doses in CT

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