Fabrication of a 3D Printed PCL Nerve Guide: In Vitro and In Vivo Testing

Usal, Tugba Dursun; Yeşiltepe, Metin; Yücel, Deniz; Sara, Yıldırım; Hasırcı, Vasıf

doi:10.1002/mabi.202100389

Cited by 13 publications

(7 citation statements)

References 52 publications

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“…Unfortunately, the performed testing data on hybrid ECS so far depict their lengthy cycle life, and their charge/discharge characteristics are predictable (voltage vs. time is almost linear for a constant current). 186,187 While hybrid ECS have shown lengthy cycle life and predictable charge/discharge characteristics based on testing data so far, the Ag-MnO 2 /MXene@NF hybrid electrode has demonstrated excellent cyclic activity, higher capacitance (1188 F g −1 @ 1 A g −1 ), and impressive rate capability (85.8% @9 A g −1 ) after 6000 tests (Fig. 11).…”

Section: Electrochemical Performance Of Mxene Hybrid Compositesmentioning

confidence: 97%

Progress and Prospects of MXene-Based Hybrid Composites for Next-Generation Energy Technology

Mohd Abdah,

Thakur

et al. 2023

J. Electrochem. Soc.

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MXenes are an emerging class of two-dimensional transition metal carbides and nitrides with metallic conductivity and hydrophilic surfaces. The discovery of MXenes has opened new possibilities for developing advanced hybrid composites for energy storage and conversion applications. This review summarizes recent advances in developing MXene-based hybrid composites, including their synthesis, characterization, and electrochemical performance. The heterostructure of MXenes with nanocarbons, metal oxides, polymers, and other nanomaterials can overcome the limitations of pristine MXenes and lead to enhanced lithium/sodium-ion storage, pseudocapacitive performance, and electrocatalytic activity. Various fabrication techniques have been employed to synthesize MXene composites with controlled nanostructures, morphology, and interfacial properties. Characterization by microscopy, spectroscopy, and electrochemical methods has shed light on structure-property relationships in these materials. As electrode materials, properly designed MXene hybrids have achieved high specific capacity, excellent rate capability, and long-term stability. The review also discusses strategies for further improving MXene composite energy storage performance, as well as emerging applications such as thermoelectrics and photocatalysis. Continued research to understand interfacial effects and optimize MXene heterostructures holds promise for developing next-generation energy storage technologies.

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Section: Electrochemical Performance Of Mxene Hybrid Compositesmentioning

confidence: 97%

Progress and Prospects of MXene-Based Hybrid Composites for Next-Generation Energy Technology

Mohd Abdah,

Thakur

et al. 2023

J. Electrochem. Soc.

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“…The resultant 3D rGO/PCL/Mel hybrid conduit exhibits a lightweight density of (144.3 ± 1.27) mg/cm 3 and the highest reported porosity of (98.5 ± 0.24)% (Figure S9), surpassing that of other natural or synthetic conduits (Fig. 3k) [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] . This remarkable achievement is attributed to the precise regulation of the rGO conduit's microstructural features, from the microscale to macroscopic dimension, by controlling the GO ink's owing state and fabrication parameters such as freeze-casting temperature.…”

Section: The Structural Characterization Of 3d Rgo/pcl/mel Conduitmentioning

confidence: 99%

“…Masson's trichrome staining was conducted to assess the differences in muscle ber recovery among three groups by comparing the muscle ber area and mean diameter. rGO/PCL/Mel conduit and another previously reported polymer scaffolds [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] . l, The tensile stress-strain curve of rGO/PCL conduit fabricated using varying concentrations of PCL precursor solution (70 mg/mL, 100 mg/mL, and 120 mg/mL).…”

Section: Evaluation Of Gastrocnemius Muscle Functionmentioning

confidence: 99%

3D Printing rGO/PCL/Mel Bionic Conduit for Peripheral Nerve Regeneration

Zhang

Liu

et al. 2023

Preprint

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The inevitable secondary victimization of patients during the grafting of autogenous nerve necessitates the urgent development of bioactive conduits for the precise repair of peripheral nerve (PN) defects. However, the limited selection of appropriate components and inferior structural designs of many porous scaffolds have hindered satisfactory PN regeneration. In this study, we created a 3D hollow conduit of reduced graphene oxide (rGO) with a hierarchically ordered microstructure through a coaxial printing methodology that enabled a physicochemically cooperative construction process at multiscale. We deposited a mixture of polycaprolactone (PCL) and melatonin (Mel) as the biologically enhancing constitution conformably over the 3D rGO templated conduit. Attributing to its elaborately designed hierarchical structure and arched alignment of 2D micro sheets, the 3D rGO/PCL/Mel hybrid bio-conduit has demonstrated remarkable structural robustness in maintaining ordered pathways and high porosity (98.5 ± 0.24%), which facilitated nerve growth in a complex survival environment in vivo. Furthermore, the excellent combination of properties such as electrical conductivity, biocompatibility, and mechanical properties (with an elastic modulus ranging from 7.06 ± 0.81 MPa to 26.58 ± 4.99 MPa), has led to highly efficient regeneration of well-ordered PN tissue. Systematic evaluations of nerve regeneration and muscle function recovery in an SD rat model with a long nerve defect (> 15 mm) have validated the virtually identical performance of the 3D rGO/PCL/Mel conduit compared to the autogenous nerve graft group. This study confirms a promising approach to clinical PN repair of long defects through the combined regulation of rational structure design on multiscale and indispensable chemical modification of rGO-based functional nerve regeneration conduits.

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“…The chemical and physical properties of biomaterials directly affect their therapeutic effect for nerve regeneration, emphasizing the importance of materials selection for tissue-engineered nerve grafts. Recently, many biodegradable materials have been used in designing scaffolds for neural tissue engineering, including synthetic polymers such as polyglycolic acid (PGA) ( Kusuhara et al, 2019 ; Sayanagi et al, 2020 ), polylactic acid (PLA) ( Jahromi et al, 2020 ), polyglycolide lactide (PGLA) ( Xu et al, 2017 ; Dos Santos et al, 2019 ; Lu P. et al, 2021 ; Manto et al, 2021 ), poly (ε-caprolactone) (PCL) ( Dong et al, 2020 ; Dursun Usal et al, 2022 ) and polyurethane (PU) ( Yang H. et al, 2022 ), etc. For example, Reid et al used a thin film of PCL to prepare nerve catheter for repairing 10 mm sciatic nerve injury in rats, and after 18 weeks, the growth rate of regenerated axons in PCL nerve catheter was comparable to that of autologous nerves ( Reid et al, 2013 ).…”

Section: Research Progress Of Peripheral Nerve Graftsmentioning

confidence: 99%

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

Jiang

Tang²,

Li³

et al. 2022

Front. Bioeng. Biotechnol.

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Peripheral nerve injury is a clinically common injury that causes sensory dysfunction and locomotor system degeneration, which seriously affects the quality of the patients’ daily life. Long gapped defects in large nerve are difficult to repair via surgery and limited donor source of autologous nerve greatly challenges the successful nerve repair by transplantation. Significantly, remarkable progress has been made in repairing the peripheral nerve injury using artificial nerve grafts and a variety of products for peripheral nerve repair have emerged been approved globally in recent years. The raw materials of these commercial products includes natural/synthetic polymers, extracellular matrix. Despite a lot of effort, the desirable functional recovery still remains great challenges in long gapped nerve defects. Thus this review discusses the recent development of tissue engineering products for peripheral nerve repair and the design of bionic grafts improving the local microenvironment for accelerating nerve regeneration against locomotor disorder, which may provide potential strategies for the repair of long gaps or thick nerve defects by multifunctional biomaterials.

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Fabrication of a 3D Printed PCL Nerve Guide: In Vitro and In Vivo Testing

Cited by 13 publications

References 52 publications

Progress and Prospects of MXene-Based Hybrid Composites for Next-Generation Energy Technology

Progress and Prospects of MXene-Based Hybrid Composites for Next-Generation Energy Technology

3D Printing rGO/PCL/Mel Bionic Conduit for Peripheral Nerve Regeneration

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

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