Fabrication of a bioadhesive transdermal device from chitosan and hyaluronic acid for the controlled release of lidocaine

Anirudhan, T.S.; Nair, Syam S.; Nair, A. Sreekumaran

doi:10.1016/j.carbpol.2016.06.101

Cited by 58 publications

(32 citation statements)

References 41 publications

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“…Anirudhan et al 16 designed a transdermal bioadhesive based on chitosan and hyaluronic acid for controlled release of lidocaine. The authors determined that the tensile force was approximately 0.5 MPa.…”

Section: Mechanical and Adhesive Propertiesmentioning

confidence: 99%

“…Ch is characterized by being biocompatible, biodegradable, bioadhesive, and non-toxic and has antimicrobial properties. [14][15][16][17] These properties facilitate the use of this material in the design of biomaterials. Some natural polysaccharides, such as Ch, are characterized by forming covalent bonds with biological tissues via bio-adhesion due to hydroxyl, carboxyl or amino groups in the structure.…”

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confidence: 99%

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Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

et al. 2017

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Section: Mechanical and Adhesive Propertiesmentioning

confidence: 99%

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confidence: 99%

Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

et al. 2017

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“…Since LID and chitosan exhibit pH-dependent solubility, [37][38][39][40] the pH of the dissolution medium will affect the dissolution of the drug from the microspheres, as shown in Figure 4a, b and c, at pH 1.2 (stomach), pH 4.5 (lysosomes), and pH 7.4 (equivalent to blood pH), respectively. At all pH values, the rate of LID release from the microspheres occurred in a biphasic process.…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

<p>The Oral Administration of Lidocaine HCl Biodegradable Microspheres: Formulation and Optimization</p>

AlQuadeib

Eltahir

Alagili

2020

IJN

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Purpose: Lidocaine (LID) is a local anesthetic that is administered either by injection and/or a topical/transdermal route. However, there is a current need to develop efficacious methods for the oral delivery of LID with optimized bioavailability. Methods: We developed oral LID biodegradable microspheres that were loaded with alginate-chitosan with different mass ratios, and characterized these microspheres in vitro. We also developed, and utilized, a simple and sensitive HPLC-tandem mass spectrometry (LC-MS-MS) method for assaying LID microspheres. Results: The mean particle size (MPS) of the LID microspheres ranged from 340.7 to 528.3 nm. As the concentration of alginate was reduced, there was a significant reduction in MPS. However, there was no significant change in drug entrapment efficiency (DEE), or drug yield, when the alginate concentration was either increased or decreased. DSC measurements demonstrated the successful loading of LID to the new formulations. After a slow initial release, less than 10% of the LID was released in vitro within 4 h at pH 1.2. In order to evaluate nephrotoxicity, we carried out MTT assays of LID in two types of cell line (LLC-PK1 and MDCK). LID significantly suppressed the cell toxicity of both cell lines at the concentrations tested (100, 200, and 400ng/µL). Conclusion: Experiments involving the oral delivery of LID formulations showed a significant reduction in particle size and an improvement in dissolution rate. The formulations of LID developed exhibit significantly less toxicity than LID alone.

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“…This pH-dependent effect was attributed to reduced hydrogen bond dissociation energy between the matrix and lidocaine molecules with increased pH. The authors concluded that the pH of transdermal microparticles and nanoparticles may also strongly affect other highly saturated transdermal drugs [73]. …”

Section: Nanoparticle Use In Transdermal Drug Deliverymentioning

confidence: 99%

Advanced Analgesic Drug Delivery and Nanobiotechnology

Stoicea

Fiorda-Diaz

Joseph

et al. 2017

Drugs

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Transdermal administration of analgesic medications offers several benefits over alternative routes of administration, including a decreased systemic drug load with fewer side effects, and avoidance of drug degradation by the gastrointestinal tract. Transdermal administration also offers a convenient mode of drug administration over an extended period of time, particularly desirable in pain medicine. A transdermal administration route may also offer increased safety for drugs with a narrow therapeutic window. The primary barrier to transdermal drug absorption is the skin itself. Transdermal nanotechnology offers a novel method of achieving enhanced dermal penetration with an extended delivery profile for analgesic drugs, due to their small size and relatively large surface area. Several materials have been used to enhance drug duration and transdermal penetration. The application of nanotechnology in transdermal delivery of analgesics has raised new questions regarding safety and ethical issues. The small molecular size of nanoparticles enables drug delivery to previously inaccessible body sites. To ensure safety, the interaction of nanoparticles with the human body requires further investigation on an individual drug basis, since different formulations have unique properties and side effects.

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Fabrication of a bioadhesive transdermal device from chitosan and hyaluronic acid for the controlled release of lidocaine

Cited by 58 publications

References 41 publications

Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

<p>The Oral Administration of Lidocaine HCl Biodegradable Microspheres: Formulation and Optimization</p>

Advanced Analgesic Drug Delivery and Nanobiotechnology

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