Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene) modified electrode

Fabrication of an Extremely Cheap Poly(3,4-ethylenedioxythiophene) Modified Pencil Lead Electrode for Effective Hydroquinone Sensing

“…Besides, some characteristic bands related to oxygen functional groups were found at 3500, 1580, 1270, and 1072 cm −1 , which might also contribute to the higher O/S element ratio in EDS analysis. Lines b demonstrated the typical spectra of PEDOT, which including asymmetric stretching vibrations of C=C and C–C in the thiophene ring at 1528 and 1372 cm −1 , bend vibration of C–O–C in the ethylenedioxy ring at 1220 and 1062 cm −1 , stretching vibrations of C–S–C bond in the thiophene ring at 980, 850, and 696 cm −1 , and possible deformation of the ethylenedioxy ring at 920 cm −1 [ 35 , 40 , 41 ]. The FTIR spectrum of PEDOT remained almost the same after HQ measurement as shown by line c, indicating the good stability of PEDOT film on the PL electrode.…”

“…Recently, we have also developed a green chemical process by using non-thermal plasma activated hydrogen peroxide to promote the synthesis of PEDOT and demonstrated the degradability of PEDOT [ 51 , 52 ]. Meanwhile, we have employed PEDOT to modify a platinum electrode to construct biosensors for sensing hydrogen peroxide and glucose [ 31 , 32 , 35 ]. So far, PEDOT has been proposed for a great variety of promising applications in bioelectronics, conductive hydrogel, and other functional materials [ 53 , 54 , 55 , 56 ].…”

“…On the other hand, there are abundant sulfur atoms in a PEDOT molecular structure that are ready for the stable immobilization of golden nanoparticles, which can then immobilize a variety of biomolecules with thiol groups (-SH) to construct various biosensors [ 31 , 32 , 33 ]. Modification of a platinum electrode with the conductive PEDOT film has also been reported to effectively eliminate the evitable hydrogen ion reduction or water oxidation at slightly negative or positive potentials [ 33 ], and to improve the sensitivity of a biosensor [ 32 , 34 , 35 , 36 ]. Therefore, the modification of GO or rGO with the conductive PEDOT will open up an era of fabricating more effective sensors for various applications.…”

“…In particular, the sulfur atoms in the PEDOT molecular structure open up the opportunity to stably capture the golden nanoparticles, which are able to immobilize a variety of biomolecules with thiol groups (-SH), such as proteins and nucleotides, to construct various biosensors [ 31 , 32 , 33 ]. Previously, we have also demonstrated that modification of a platinum electrode with the conductive PEDOT film could effectively eliminate the hydrogen ion reduction and water oxidation at slightly negative or positive potentials [ 33 ], which provided limited background interference for a sensitive detection [ 32 , 34 , 35 , 36 ].…”

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

“…A LOD of 0.1 μM with a linear range of 2 × 10 −6 –4.5 × 10 −3 M, and a repeatability of 7.1% as RSD ( n = 5) for 5 mM glucose in the presence of 0.5 mM of AA and UA. PEDOT films were electrochemically deposited on a Pt electrode with bovine serum albumin as a platform for Pt/PEDOT-BSA/AuNP-GOx sensors [ 169 ]. FTIR, analysis shows no disruption of PEDOT film by the posterior modifications.…”