Fabrication of a biodegradable drug delivery system with controlled release made of PLGA/5‐FU/hydroxyapatite

Abstract

Purpose -Rapid prototyping (RP) technology has been widely applied in biomedical research. The purpose of this paper is to describe how a scaffold composite drug delivery system (DDS) was fabricated using a nano composite deposition system (NCDS). Design/methodology/approach -A biocompatible and biodegradable thermoplastic polymer (poly(DL-lactide-co-glycolide acid)) was used as the matrix, and a mixture of anti-cancer drug (5-fluorouracil) and bio-ceramic (hydroxyapatite -HA) was added to the polymer to form a bio-composite material for the DDS. An in vitro drug release test showed that the release rate of the drug composite could be controlled by the amount of HA for 50 days. Findings -Faster release was observed for the DDS with higher weight percent of HA. The relationship between release rate and the amount of HA showed a bi-linear manner, and bi-linear drug release models were developed based on the experimental results. Originality/value -Cylindrical scaffolds were fabricated with polymer/drug/additive using an NCDS. A series of in vitro drug release tests was performed to evaluate the effectiveness of the additive, HA. Drug release models were developed based on the experimental results.

Robocasting nanocomposite scaffolds of poly(caprolactone)/hydroxyapatite incorporating modified carbon nanotubes for hard tissue reconstruction

“…Recently, robotic dispensing has emerged as a potential technique to produce scaffolds with complex structural architecture such as shape and size and pore geometry that can be tuned to specific applications 13–17. A range of materials has been developed into robotic dispensed scaffolds including degradable polymers, bioactive ceramics, and their composites 13–19…”

“…[13][14][15][16][17] A range of materials has been developed into robotic dispensed scaffolds including degradable polymers, bioactive ceramics, and their composites. [13][14][15][16][17][18][19] The composite approach is regarded as particularly effective in obtaining scaffolds appropriate to hard-tissue regeneration in terms of biological and mechanical aspects. When compared to pure polymer scaffolds such as poly(caprolactone) (PCL) and poly(lactic acid) (PLA), incorporation of calcium phosphates and bioactive glasses has largely been shown to improve biological responses such as in vitro cell growth and bone cell differentiation as well as in vivo bone regeneration.…”

Flexible ceramic-elastomer composite piezoelectric energy harvester fabricated by additive manufacturing

“…Despite the progress of piezoelectric energy harvesting technology, there has not been a prominent application or market growth offered through the To open up the new stage of piezoelectric energy harvesting technology, there is a need to develop a piezoelectric energy harvester fabricated by the manufacturing technique which enables proper customization of piezoelectric energy harvesters to various fields. Here, we describe a flexible piezoelectric energy harvester fabricated by novel and simple method using a nanocomposite deposition system (NCDS), 23,24 which is an additive manufacturing processes involving fused deposition methods. NCDS is a technology that enables free-form objects of polymer and polymer-based composite to be fabricated directly.…”

“…Here, we describe a flexible piezoelectric energy harvester fabricated by novel and simple method using a nanocomposite deposition system (NCDS), 23,24 which is an additive manufacturing processes involving fused deposition methods. NCDS is a technology that enables free-form objects of polymer and polymer-based composite to be fabricated directly.…”

“…NCDS is a technology that enables free-form objects of polymer and polymer-based composite to be fabricated directly. As additive manufacturing has significant advantages in terms of rapid design-toproduction times and customization, [19][20][21][22][23][24][25] NCDS provides rapid fabrication of customized piezoelectric energy harvester by printing piezoelectric composite materials.…”