Fabrication of a dendrimer-modified boronate affinity material for online selective enrichment of cis-diol-containing compounds and its application in determination of nucleosides in urine

Gao, Li; Du, Jin; Wang, Chaozhan; Wei, Yinmao

doi:10.1039/c5ra18443f

Cited by 33 publications

(8 citation statements)

References 55 publications

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“…In recent years, boronate affinity materials (BAMs) have been studied and optimized to enable various promising applications for the selective enrichment of compounds containing cis-diols [47,48]. The binding to BAMs is pH-controlled, covalent, and reversible, making this method perfect for the capture and recognition, as well as the labeling and assays of cis-diol containing molecules, including catechols [49], nucleosides, nucleotides [50], and glycoproteins [45,51,52] (Figure 4). The cis-diols interact with boronate ions in alkaline conditions, which may be inconvenient in the case of labile compounds.…”

Section: Boronate Affinity Separation For Glycoconjugates Capturementioning

confidence: 99%

Veni, Vidi, Vici: Immobilized Peptide-Based Conjugates as Tools for Capture, Analysis, and Transformation

et al. 2022

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Analysis of peptide biomarkers of pathological states of the organism is often a serious challenge, due to a very complex composition of the cell and insufficient sensitivity of the current analytical methods (including mass spectrometry). One of the possible ways to overcome this problem is sample enrichment by capturing the selected components using a specific solid support. Another option is increasing the detectability of the desired compound by its selective tagging. Appropriately modified and immobilized peptides can be used for these purposes. In addition, they find application in studying the specificity and activity of proteolytic enzymes. Immobilized heterocyclic peptide conjugates may serve as metal ligands, to form complexes used as catalysts or analytical markers. In this review, we describe various applications of immobilized peptides, including selective capturing of cysteine-containing peptides, tagging of the carbonyl compounds to increase the sensitivity of their detection, enrichment of biological samples in deoxyfructosylated peptides, and fishing out of tyrosine–containing peptides by the formation of azo bond. Moreover, the use of the one-bead-one-compound peptide library for the analysis of substrate specificity and activity of caspases is described. Furthermore, the evolution of immobilization from the solid support used in peptide synthesis to nanocarriers is presented. Taken together, the examples presented here demonstrate immobilized peptides as a multifunctional tool, which can be successfully used to solve multiple analytical problems.

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Section: Boronate Affinity Separation For Glycoconjugates Capturementioning

confidence: 99%

Veni, Vidi, Vici: Immobilized Peptide-Based Conjugates as Tools for Capture, Analysis, and Transformation

et al. 2022

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“…To provide reliable quantification, establishing calibration curves by using a matched matrix that spiked with standard target analytes are preferred [8,41,42].…”

Section: Methods Validation and Applicationmentioning

confidence: 99%

“…Recently, Li et al [ 7] reported a comprehensive review on the research progress of boronate affinity materials in last decades, wherein they pointed out that the material structure also has significant effects on the properties of boronate affinity materials in addition to the boronic acid ligands. In this respect, different types of boronate functionalized materials have been developed as SPE sorbents, such as monoliths [6], silica gel [8,9], organic polymers [10], metal oxides [11] and magnetic naomaterials (including nanoparticles and their composites) [7].…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of a boronate affinity sorbent from mesoporous nanomagnetic polyhedral oligomeric silsesquioxanes composite and its application for enrichment of catecholamines in human urine

Zhou

Dong

et al. 2016

Analytica Chimica Acta

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“…. Silica‐Cl and SiO 2 ‐NH 2 were prepared according to the reported method . Briefly, 2.0 g of silica was placed in a flask, and then 40 mL of dried toluene and 0.9 mL of 4‐(chloromethyl) phenyltrimethoxy silane were added under nitrogen.…”

Section: Methodsmentioning

confidence: 99%

Fabrication of a novel hydrophobic/ion‐exchange mixed‐mode adsorbent for the dispersive solid‐phase extraction of chlorophenols from environmental water samples

Gao

Wei

2016

J of Separation Science

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A novel mixed-mode adsorbent was prepared by functionalizing silica with tris(2-aminoethyl)amine and 3-phenoxybenzaldehyde as the main mixed-mode scaffold due to the presence of the plentiful amino groups and benzene rings in their molecules. The adsorption mechanism was probed with acidic, natural and basic compounds, and the mixed hydrophobic and ion-exchange interactions were found to be responsible for the adsorption of analytes. The suitability of dispersive solid-phase extraction was demonstrated in the determination of chlorophenols in environmental water. Several parameters, including sample pH, desorption solvent, ionic strength, adsorbent dose, and extraction time were optimized. Under the optimal extraction conditions, the proposed dispersive solid-phase extraction coupled with high-performance liquid chromatography showed good linearity range and acceptable limits of detection (0.22∽0.54 ng/mL) for five chlorophenols. Notably, the higher extraction recoveries (88.7∽109.7%) for five chlorophenols were obtained with smaller adsorbent dose (10 mg) and shorter extraction time (15 min) compared with the reported methods. The proposed method might be potentially applied in the determination of trace chlorophenols in real water samples.

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Fabrication of a dendrimer-modified boronate affinity material for online selective enrichment of cis-diol-containing compounds and its application in determination of nucleosides in urine

Abstract: A high binding capacity dendrimer-modified boronate affinity material (SiO2@dBA) was synthesized and coupled with large-volume injection/online column-switching solid phase extraction to facilitate the determination process of cis-diols.

Cited by 33 publications

References 55 publications

Veni, Vidi, Vici: Immobilized Peptide-Based Conjugates as Tools for Capture, Analysis, and Transformation

Veni, Vidi, Vici: Immobilized Peptide-Based Conjugates as Tools for Capture, Analysis, and Transformation

Facile synthesis of a boronate affinity sorbent from mesoporous nanomagnetic polyhedral oligomeric silsesquioxanes composite and its application for enrichment of catecholamines in human urine

Fabrication of a novel hydrophobic/ion‐exchange mixed‐mode adsorbent for the dispersive solid‐phase extraction of chlorophenols from environmental water samples

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