Fabrication of a microdialysis-based nonenzymatic microfluidic sensor for regular glucose measurement

Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement

“…The height of the channels was chosen 60 μm, since the height of the sensor to which these channels carry the dialysis fluid is 60 μm [10] , so that there would be no height difference. Since the inner diameter of each microneedle is 30 μm [26] , there was chosen a 50 μm width for each microchannel located above the microneedles in order to provide enough margin for covering the inner diameter of microneedles.…”

“…From the chemical viewpoint, glucose can be electrochemically detected either with an enzymatic or with a nonenzymatic method. While the enzymatic sensors suffer from difficulty of enzyme immobilization, low chemical and thermal stability and activity changes following the changes in environmental conditions, nonenzymatic sensors, which can be more easily manufactured, show higher chemical and thermal stability [ 10 , 11 ].…”

“…Our main goal is to design an integrated implantable microfluidic system according to the microdialysis method in order to regularly and painlessly measure glucose in diabetic patients in a nonenzymatic way. In our previous work [10] , we designed and fabricated a promising novel microfluidic nonenzymatic glucose sensor. In following the very work, here we address the other parts of the entire system.…”

Fluidic enabled bioelectronic implants: opportunities and challenges

“…58,59 Microfluidic based wearables are used extensively for continuous health monitoring, disease detection and sports science. [60][61][62][63] Many different analytes can be detected in a wearable or in vitro capacity, with glucose being the most prolific clinically relevant biomarker studied for novel sensing strategies [64][65][66] . In addition to the sensing of biomarkers, the use of microfluidic devices for pressure-sensing is abundant [67][68][69][70] .…”

“…[60][61][62][63] Many different analytes can be detected in a wearable or in vitro capacity, with glucose being the most prolific clinically relevant biomarker studied for novel sensing strategies. [64][65][66] In addition to the sensing of biomarkers, the use of microfluidic devices for pressure-sensing is abundant. [67][68][69][70] Implantable devices are less common than wearables but there are certain applications where their passive, long-term and high-resolution capability are advantageous.…”