Fabrication of a Stable and Efficient Antibacterial Nanocoating of Zn‐CuO on Contact Lenses

Abstract

The problem of bacterial infections in general,a nd in medicald evices in particular,h as led to extensive research to produce antibacterial coatings. The current research presents au nique technique for imparting antibacterial properties to contact lenses. The coating consists of nanoparticles of zinc-doped coppero xide. In the coating process, active nanoparticles are formed and immediately depositedo nto the surfaceo ft he contact lens. The coating thus formed is homogeneous and stable, withoutl eaching of the nanoparticles. The antibacterial activity was evaluated against Grampositivea nd Gram-negative bacteria. The optimization of the coating processh as led to as maller particle size and good antibacterial activity.

Novel Antimicrobial Coating on Silicone Contact Lens Using Glycidyl Methacrylate and Polyethyleneimine Based Polymers

“…Tuby et al. [ 23 ] reported efficient antibacterial nanocoatings of zinc doped copper oxide on contact lens. A new way to deposit biocompatible nanocomposite coating on silicon hydrogel contact lens to minimize UV exposure and biofouling was reported by Huang et al.…”

Contact lens, high refractive index, abbe number, hybrid materials, fabrication, enhancement

“…On the other hand, organic-inorganic Zinc bis (Allyl-Dithiocarbamate) (Zn (ADTC 2 )) composed of allylamines, zinc nitrate and carbon disulfide were prepared by using Zn (DADTC) 2 and Zn (APDTC) 2 content of 18 and 30 wt.%, respectively; the resultant polymer characterized by high flexibility and high transparency to achieve (1.71 and 1.67) RI (Nagayama and Ochiai, 2016). Zinc also used extensively to prepare nanoparticle antibacterial coatings applied on CLs surfaces (Tuby et al, 2016), also the hybrid ZnO/PMMA polymer provides a colorless film of (1.6) RI which can be considered useful in such applications (Wang et al, 2017). ZnS nanoparticles have employed to obtain polymerized nanocomposite grafted with ZnS where a copolymerization process with a mixture of N, N-dimethylacrylamide (DMA) and (HEMA) or Glycidyl Methacrylate (GMA) or Methyl Methacrylate (MMA), the produced polymer exhibits a transmittance above 92% in visible region and RI range of 1.652 and 1.751 after changing ZnS content from 33.4-50.3 wt.%…”

Poly(2‐hydroxyethyl methacrylate)/boric acid composite hydrogel as soft contact lens material: Thermal, optical, rheological, and enhanced antibacterial properties

“…To determination of functional groups in the macromolecule chains, pure PHEMA and PHEMA/BA composite hydrogels with different concentration of BA were characterized using a FTIR spectrometer (Mattson 1000) in the wavenumber range 400-4000 cm 21 . Also, thermogravimetric analyzer (TGA-50, Shimadzu), differential thermal analysis (DTA-50 Shimadzu), and differential scanning calorimetry (DSC-60, Shimadzu) were used to analyze the thermal property of all samples.…”

“…Considering about 145 million people use contact lenses worldwide this serious problem must be solved very quickly. Recent efforts in contact lens applications have focused on composite materials formed by incorporating micro/nano particles into lens materials for safe daily wear and sustainable drug release . For instance, Helaly et al .…”

“…Recent efforts in contact lens applications have focused on composite materials formed by incorporating micro/nano particles into lens materials for safe daily wear and sustainable drug release. [20][21][22] For instance, Helaly et al 20 synthesized and characterized of nanosilver-silicone hydrogel composites to inhibit of bacteria growth. Firstly, they prepared nanosilver-silicone hydrogel composites using diffusion and in situ chemical reduction process.…”