2023
DOI: 10.1186/s40824-023-00457-9
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Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system

Dana M. Alhattab,
Ioannis Isaioglou,
Salwa Alshehri
et al.

Abstract: Background Acute myeloid leukemia (AML) is a hematological malignancy that remains a therapeutic challenge due to the high incidence of disease relapse. To better understand resistance mechanisms and identify novel therapies, robust preclinical models mimicking the bone marrow (BM) microenvironment are needed. This study aimed to achieve an automated fabrication process of a three-dimensional (3D) AML disease model that recapitulates the 3D spatial structure of the BM microenvironment and appli… Show more

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Cited by 5 publications
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“…It is not as common to see systematic transcriptomic approaches in CM–BM research as in other disease studies (e.g., cancer research ). Although transcriptomic approaches offer insights into molecular mechanisms underlying CM–BM interactions and provide instructions for cardiac biomedical engineering, some challenges remain (Figure ).…”
Section: Challenges and Prospects Of Transcriptomic Approaches In Car...mentioning
confidence: 99%
“…It is not as common to see systematic transcriptomic approaches in CM–BM research as in other disease studies (e.g., cancer research ). Although transcriptomic approaches offer insights into molecular mechanisms underlying CM–BM interactions and provide instructions for cardiac biomedical engineering, some challenges remain (Figure ).…”
Section: Challenges and Prospects Of Transcriptomic Approaches In Car...mentioning
confidence: 99%